DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fkh and mei4

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_595617.1	Gene:	mei4 / 2540241	PomBaseID:	SPBC32H8.11	Length:	517	Species:	Schizosaccharomyces pombe

Alignment Length:	485	Identity:	108/485 - (22%)
Similarity:	168/485 - (34%)	Gaps:	116/485 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 THAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKI 271
            |..|||.||.:||.:||..:..:.||||.||.:|.:.|.:|..:...|||||||:||.|..|:|:
pombe    78 TGEKPPCSYATLIGLAILQSHNKQLTLSGIYTWIRNTFRYYLNHDGGWQNSIRHNLSLNKAFIKV 142

  Fly   272 PRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKDH 336
            .:...|..||.:||:.||....|                 .::| ||:|.|..|.....|..|.|
pombe   143 EKPKGKTLKGHYWTIDPDHMQNF-----------------VSVR-LHRSHSTDSNSKKRPSSKCH 189

  Fly   337 EDSHHMHH-----HHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAELCLSQQP 396
            |.......     ...|||:.........|:|    :.::|..|.||               .||
pombe   190 EIKPLTTREIPLARKRSRLNSFNSSTSTSGSS----SNVAAEVSNDA---------------SQP 235

  Fly   397 QHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSINRLLPT- 460
            .:            |...|::.:.....|......:||......:|:..|...        |||
pombe   236 SN------------QDSSLNSNIVKPPLPPSNVQSNSSSSENVPKPNAETQED--------LPTI 280

  Fly   461 --------ESKADIKMYD------MSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSLX 511
                    |:..|.::|:      |:...||:...|                 || ......|..
pombe   281 DAHESSLYENVNDSRLYEVPACRNMALNTGYSDADP-----------------GY-LRTSFRSNS 327

  Fly   512 HHQYPLAXGRAEQMLRS----QQQQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLTSASNTPA 572
            |:..|.:....|.:|::    .||..:...:...:.........::...::.|::   ....|..
pombe   328 HNSLPYSANEEEDVLQADFLVSQQSSMVSSYVSSRDPHSMPYYRREPIPLRPSSR---FYEYTRP 389

  Fly   573 TSAKASGKAGSASASGSGSGSGSGSGSNYSQKLQQQHQQQQQQQAAAQQQHHQQQQQLL--QELQ 635
            |..:......:..|..|...:...|..|||       :........:.|:|.:..:.||  .:|.
pombe   390 TYGRTDTSCSAPGAFCSTQINSPSSYINYS-------KCAPSSPTLSLQKHREHVKSLLYVPDLT 447

  Fly   636 -----EDSSNITSDLSEEQLQQHQAAQQQL 660
                 .|..|.:|.|..|.|....:.|..|
pombe   448 PSFDGSDPWNPSSQLLSEPLFDQHSFQSSL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	1/1 (100%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	38/87 (44%)
mei4	NP_595617.1	COG5025	1..517	CDD:227358	108/485 (22%)
mei4	NP_595617.1	Forkhead	81..167	CDD:278670	38/102 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	104	1.000	Domainoid score	I1720
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010