DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and FOXD2

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_004465.3	Gene:	FOXD2 / 2306	HGNCID:	3803	Length:	495	Species:	Homo sapiens

Alignment Length:	356	Identity:	115/356 - (32%)
Similarity:	144/356 - (40%)	Gaps:	120/356 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SAPVSMASSGGGGPPSGGGGGGGG-GGGGGPPPPSNNNPNPTSNGGSMSPLARSAYTMNSMGLPV 75
            |:|.:::.:.......|||.|||. ....||..|.:..|:     |...|...:...:.......
Human    15 SSPAALSEADADIDVVGGGSGGGELPARSGPRAPRDVLPH-----GHEPPAEEAEADLAEDEEES 74

  Fly    76 GGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMSASMNASMNGSMGAAAMNSMGGNCMTPSS 140
            ||.|...|:|.|                                  |.|||
Human    75 GGCSDGEPRALA----------------------------------SRGAA-------------- 91

  Fly   141 MSYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYRRS 205
               |:.|||                ..|.:...||..||     .|.|:  |.:....|.
Human    92 ---AAAGSP----------------GPGAAAARGAAGPG-----PGPPS--GGAATRSPL----- 125

  Fly   206 YTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVK 270
               .|||||||:||||||..:|.:.||||||.:||...||:||:....|||||||:||.||||||
Human   126 ---VKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVK 187

  Fly   271 IPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKD 335
            |||.|..||||::|||.|:|.:||:||.:|||:||||       ||....|
Human   188 IPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFK-------RQPLPPP-------------- 231

  Fly   336 HEDSHHMHHHHHSRLDHHQHHKEAGGASIAG 366
                 |.|.|.|..|      ...|||:.||
Human   232 -----HPHPHPHPEL------LLRGGAAAAG 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	17/88 (19%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	57/87 (66%)
FOXD2	NP_004465.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..122		36/185 (19%)
		Forkhead	127..213	CDD:278670	56/85 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..347
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..444
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910