Protein Alignment fkh and FOXC2

DIOPT Version :9

• Sequence 1: NP_001263038.1
• Gene: fkh / 43383
• FlyBaseID: FBgn0000659
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_005242.1
• Gene: FOXC2 / 2303
• HGNCID: 3801
• Length: 501
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 158/538 - (29%)
• Similarity: 218/538 - (40%)
• Gaps: 128/538 - (23%)

  Fly   142 SYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYRRSY 206
            ||..|.||:|...|     .....:||:..:|...    ...:..:|..|
Human    30 SYGGMASPMGVYSG-----HPEQYSAGMGRSYAPY----HHHQPAAPKDL--------------- 70

  Fly   207 THAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKI 271
              .|||||||:||||||||.|.:.:||:.|||||||.|||||:|:|.|||||||:||.|:||||:
Human    71 --VKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKV 133

  Fly   272 PRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKDH 336
            ||...||||||:|||.|||.||||||.:|||::|||  ||:.                   .|:.
Human   134 PRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFK--KKDV-------------------SKEK 177

  Fly   337 EDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDA--EALAMLHANAELCLSQQPQHV 399
            |:..|:              ||...|:..|..  :..|..||  ||...:...:|......|  |
Human   178 EERAHL--------------KEPPPAASKGAP--ATPHLADAPKEAEKKVVIKSEAASPALP--V 224

  Fly   400 PTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSINRLLPTESKA 464
            .|         :.|.||...|.:..|      .|:.......|.|..|..|..:.|. ||..|..
Human   225 IT---------KVETLSPESALQGSP------RSAASTPAGSPDGSLPEHHAAAPNG-LPGFSVE 273

  Fly   465 DIKMY-------DMSQYAGYNAL--SPLTNSHAALGQDSYYQSLGYHAPAGTTSLXHHQYPLAXG 520
            :|...       ::|..||...|  .||...:||....:|.|.......||           |.|
Human   274 NIMTLRTSPPGGELSPGAGRAGLVVPPLALPYAAAPPAAYGQPCAQGLEAG-----------AAG 327

  Fly   521 RAEQMLRSQQQQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLTSASNTPATSAK-ASGKAGSA 584
            ..:..:|: ...:...:...|.         .....:.::.....|...:|.::.. |:|:.|:.
Human   328 GYQCSMRA-MSLYTGAERPAHM---------CVPPALDEALSDHPSGPTSPLSALNLAAGQEGAL 382

  Fly   585 SASGSGSGSGSGSGSNYSQKLQQQHQQQQQQQAAAQQQHHQQQQQLLQELQEDSSNITSDLSEEQ 649
            :|:|           ::.|.....|.|......|.|.|...|......:......|.:.||:  .
Human   383 AATG-----------HHHQHHGHHHPQAPPPPPAPQPQPTPQPGAAAAQAASWYLNHSGDLN--H 434

  Fly   650 LQQHQ-AAQQQLYNNYQQ 666
            |..|. |||||.:.|.::
Human   435 LPGHTFAAQQQTFPNVRE 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	12/66 (18%)
		FH	210..298	CDD:214627	65/87 (75%)
FOXC2	NP_005242.1	FH	72..160	CDD:214627	65/87 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..208		16/77 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..268		9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..420		9/47 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910