DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and FOXL1

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_005241.1	Gene:	FOXL1 / 2300	HGNCID:	3817	Length:	345	Species:	Homo sapiens

Alignment Length:	191	Identity:	84/191 - (43%)
Similarity:	107/191 - (56%)	Gaps:	35/191 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 RSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCF 268
            |:.|..|||||||:||.||||:.|.:.:||:.|||||||.||||..|:|.|||||||:||.||||
Human    43 RAETPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNDCF 107

  Fly   269 VKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGK 333
            ||:||...:|||||:|||.|...:|||||.|.||:::.|             |...:.||..|..
Human   108 VKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPK-------------PGPGAPEAKRPRA 159

  Fly   334 KDHEDSHHMHHHHHSRLDHHQHHKEAG---GASIAGVNVLSAAHSKDAEAL------AMLH 385
            :.|:.|             .:...|||   |.|...::.|.||.:..:..|      |.||
Human   160 ETHQRS-------------AEAQPEAGSGAGGSGPAISRLQAAPAGPSPLLDGPSPPAPLH 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	2/4 (50%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	59/87 (68%)
FOXL1	NP_005241.1	FH	49..137	CDD:214627	59/87 (68%)
FOXL1	NP_005241.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..289		23/98 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910