DRSC/TRiP Functional Genomics Resources

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Protein Alignment fkh and FOXC1

DIOPT Version :9

Sequence 1:NP_001263038.1 Gene:fkh / 43383 FlyBaseID:FBgn0000659 Length:692 Species:Drosophila melanogaster
Sequence 2:NP_001444.2 Gene:FOXC1 / 2296 HGNCID:3800 Length:553 Species:Homo sapiens


Alignment Length:592 Identity:169/592 - (28%)
Similarity:235/592 - (39%) Gaps:163/592 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 SMGSP--LG---NMGGCMAMSAASMSAAGLSGTYGAMP--------PGSREMETGSPNSLGRSRV 196
            |:.||  ||   .:||..:...|:.:|||  |.|.|||        |...|...|     |.:|.
Human     6 SVSSPNSLGVVPYLGGEQSYYRAAAAAAG--GGYTAMPAPMSVYSHPAHAEQYPG-----GMARA 63

  Fly   197 DKP-TTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRH 260
            ..| |...:.....|||||||:||||||||.|.:.:||:.|||||||.|||||.|:|.|||||||
Human    64 YGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRH 128

  Fly   261 SLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSS 325
            :||.|:||||:||...||||||:|||.|||.||||||.:|||::|||  ||:|::...:......
Human   129 NLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFK--KKDAVKDKEEKDRLHL 191

  Fly   326 LEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAEL 390
            .|...||::.                                   ..|..:.|:      .||. 
Human   192 KEPPPPGRQP-----------------------------------PPAPPEQAD------GNAP- 214

  Fly   391 CLSQQP-----QHVPTHHHHQHHQLQQEELSAMMAN---RCHPSLIT-DYHSSMHPLKQEPSGYT 446
              ..||     |.:.|.:.......|....:|.:.:   ...|.:.: |..||.......|.|..
Human   215 --GPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAAAVPKIESPDSSSSSLSSGSSPPGSL 277

  Fly   447 PSSHPFSI---NRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTT 508
            ||:.|.|:   :...|..:.:....:....::..|.::.|..|..:...:   .|.|..|.|..:
Human   278 PSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAAE---LSSGLLASAAAS 339

  Fly   509 SLXHHQYPLAXGRAEQMLRSQQQQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLTSASNTPAT 573
            |......|||.|                                     ..|..| :|..::|.:
Human   340 SRAGIAPPLALG-------------------------------------AYSPGQ-SSLYSSPCS 366

  Fly   574 SAKASGKAGSASASGSGSGSGSGSGSNYSQKLQQQHQQQQQQQAAAQQQHHQQ-----------Q 627
            ...::|.:| ....|:|:..|:|....|...|     |.....||.::..|.|           .
Human   367 QTSSAGSSG-GGGGGAGAAGGAGGAGTYHCNL-----QAMSLYAAGERGGHLQGAPGGAGGSAVD 425

  Fly   628 QQLLQ-ELQEDSSNITSDLSE----------EQLQQHQAAQQ-QLYNNYQQY------------- 667
            ..|.. .|...:|:.:|.||.          ::...|.||.| :|.:.|...             
Human   426 DPLPDYSLPPVTSSSSSSLSHGGGGGGGGGGQEAGHHPAAHQGRLTSWYLNQAGGDLGHLASAAA 490

  Fly   668 -AAAAGY 673
             ||||||
Human   491 AAAAAGY 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fkhNP_001263038.1 Forkhead_N <120..209 CDD:254796 23/77 (30%)
FH 210..298 CDD:214627 65/87 (75%)
FOXC1NP_001444.2 Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 1..51 16/46 (35%)
FH 78..166 CDD:214627 65/87 (75%)
Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269|PubMed:11782474 78..93 13/14 (93%)
Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269|PubMed:11782474 168..176 6/9 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..310 30/182 (16%)
Required for transcriptional inhibition. /evidence=ECO:0000269|PubMed:11782474 215..366 33/191 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..387 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..465 7/50 (14%)
Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 466..553 9/32 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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