Protein Alignment fkh and Foxc1

DIOPT Version :10

• Sequence 1: NP_001263038.1
• Gene: fkh / 43383
• FlyBaseID: FBgn0000659
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_032618.2
• Gene: Foxc1 / 17300
• MGIID: 1347466
• Length: 553
• Species: Mus musculus
• Alignment Length: 592
• Identity: 174/592 - (29%)
• Similarity: 234/592 - (39%)
• Gaps: 163/592 - (27%)

  Fly   145 SMGSP--LG---NMGGCMAMSAASMSAAGLSGTYGAMP--------PGSREMETGSPNSLGRSRV 196
            |:.||  ||   .:||..:...|:.:|||  |.|.|||        |...|...||     .:|.
Mouse     6 SVSSPNSLGVVPYLGGEQSYYRAAAAAAG--GGYTAMPAPMSVYSHPAHAEQYPGS-----MARA 63

  Fly   197 DKP-TTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRH 260
            ..| |...:.....|||||||:||||||||.|.:.:||:.|||||||.|||||.|:|.|||||||
Mouse    64 YGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRH 128

  Fly   261 SLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSS 325
            :||.|:||||:||...||||||:|||.|||.||||||.:|||::|||  ||:|:
Mouse   129 NLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFK--KKDAV----------- 180

  Fly   326 LEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAEL 390
                    ||.|:...:|.       ......:||...       :.|..:.||..|.
Mouse   181 --------KDKEEKGRLHL-------QEPPPPQAGRQP-------APAPPEQAEGSAP------- 216

  Fly   391 CLSQQP-----QHVPTHHHHQHHQLQQEELSAMMANRCHPSL----ITDYHSSMHPLKQEPSGYT 446
              ..||     |.:.|.:.......|....:|.:.:....::    ..|..||.......|.|..
Mouse   217 --GPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESPDSSSSSLSSGSSPPGSL 279

  Fly   447 PSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTN-------SHAALGQDSYYQSLGYHAP 504
            ||:.|.|::...|............||  |::..:.:|:       |.|.||.       |..|.
Mouse   280 PSARPLSLDAAEPAPPPQPAPPPHHSQ--GFSVDNIMTSLRGSPQGSAAELGS-------GLLAS 335

  Fly   505 AGTTSLXHHQYPLAXGRAEQMLRSQQQQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLTSASN 569
            |..:|......|||.|                                   ........|.|:..
Mouse   336 AAASSRAGIAPPLALG-----------------------------------AYSPGQSSLYSSPC 365

  Fly   570 TPATSAKASGKAGSASASGSGSGSGSGSG--SNYSQKLQQQHQQQQQQQAAAQQQHHQQ------ 626
            :.::||.:||..|.....|.||.|.:|:|  :.|...|     |.....||.::..|.|
Mouse   366 SQSSSAGSSGGGGGGGGGGGGSSSAAGTGGAATYHCNL-----QAMSLYAAGERGGHLQGPAGGA 425

  Fly   627 ----------QQQLLQELQEDSSNITSDLSEEQLQQHQAAQQ-QLYNNYQQY------------- 667
                      ...|.......||:::.....::...|.|:.| :|.:.|...
Mouse   426 GSAAVDDPLPDYSLPPATSSSSSSLSHGGGGQEASHHPASHQGRLTSWYLNQAGGDLGHLASAAA 490

  Fly   668 -AAAAGY 673
             ||||||
Mouse   491 AAAAAGY 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:369872	23/77 (30%)
		FH_dFKH	210..307	CDD:410815	70/96 (73%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250|UniProtKB:Q12948	1..51		16/46 (35%)
		FH_FOXC1	73..165	CDD:410818	64/91 (70%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250|UniProtKB:Q12948	78..93		13/14 (93%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250|UniProtKB:Q12948	168..176		6/9 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..326		37/198 (19%)
		Required for transcriptional inhibition. /evidence=ECO:0000250|UniProtKB:Q12948	217..366		34/192 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..393		11/36 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..466		5/45 (11%)
		Required for transcriptional activation. /evidence=ECO:0000250|UniProtKB:Q12948	466..553		9/32 (28%)