DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fkh and Foxc1

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_032618.2	Gene:	Foxc1 / 17300	MGIID:	1347466	Length:	553	Species:	Mus musculus

Alignment Length:	592	Identity:	174/592 - (29%)
Similarity:	234/592 - (39%)	Gaps:	163/592 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 SMGSP--LG---NMGGCMAMSAASMSAAGLSGTYGAMP--------PGSREMETGSPNSLGRSRV 196
            |:.||  ||   .:||..:...|:.:|||  |.|.|||        |...|...||     .:|.
Mouse     6 SVSSPNSLGVVPYLGGEQSYYRAAAAAAG--GGYTAMPAPMSVYSHPAHAEQYPGS-----MARA 63

  Fly   197 DKP-TTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRH 260
            ..| |...:.....|||||||:||||||||.|.:.:||:.|||||||.|||||.|:|.|||||||
Mouse    64 YGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRH 128

  Fly   261 SLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSS 325
            :||.|:||||:||...||||||:|||.|||.||||||.:|||::|||  ||:|:
Mouse   129 NLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFK--KKDAV----------- 180

  Fly   326 LEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAEL 390
                    ||.|:...:|.       ......:||...       :.|..:.||..|.
Mouse   181 --------KDKEEKGRLHL-------QEPPPPQAGRQP-------APAPPEQAEGSAP------- 216

  Fly   391 CLSQQP-----QHVPTHHHHQHHQLQQEELSAMMANRCHPSL----ITDYHSSMHPLKQEPSGYT 446
              ..||     |.:.|.:.......|....:|.:.:....::    ..|..||.......|.|..
Mouse   217 --GPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESPDSSSSSLSSGSSPPGSL 279

  Fly   447 PSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTN-------SHAALGQDSYYQSLGYHAP 504
            ||:.|.|::...|............||  |::..:.:|:       |.|.||.       |..|.
Mouse   280 PSARPLSLDAAEPAPPPQPAPPPHHSQ--GFSVDNIMTSLRGSPQGSAAELGS-------GLLAS 335

  Fly   505 AGTTSLXHHQYPLAXGRAEQMLRSQQQQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLTSASN 569
            |..:|......|||.|                                   ........|.|:..
Mouse   336 AAASSRAGIAPPLALG-----------------------------------AYSPGQSSLYSSPC 365

  Fly   570 TPATSAKASGKAGSASASGSGSGSGSGSG--SNYSQKLQQQHQQQQQQQAAAQQQHHQQ------ 626
            :.::||.:||..|.....|.||.|.:|:|  :.|...|     |.....||.::..|.|
Mouse   366 SQSSSAGSSGGGGGGGGGGGGSSSAAGTGGAATYHCNL-----QAMSLYAAGERGGHLQGPAGGA 425

  Fly   627 ----------QQQLLQELQEDSSNITSDLSEEQLQQHQAAQQ-QLYNNYQQY------------- 667
                      ...|.......||:::.....::...|.|:.| :|.:.|...
Mouse   426 GSAAVDDPLPDYSLPPATSSSSSSLSHGGGGQEASHHPASHQGRLTSWYLNQAGGDLGHLASAAA 490

  Fly   668 -AAAAGY 673
             ||||||
Mouse   491 AAAAAGY 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	23/77 (30%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	65/87 (75%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	1..51		16/46 (35%)
		FH	78..166	CDD:214627	65/87 (75%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250\|UniProtKB:Q12948	78..93		13/14 (93%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250\|UniProtKB:Q12948	168..176		6/9 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..326		37/198 (19%)
		Required for transcriptional inhibition. /evidence=ECO:0000250\|UniProtKB:Q12948	217..366		34/192 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..393		11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..466		5/45 (11%)
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	466..553		9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910