DRSC/TRiP Functional Genomics Resources

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Protein Alignment fkh and Foxa2

DIOPT Version :9

Sequence 1:NP_001263038.1 Gene:fkh / 43383 FlyBaseID:FBgn0000659 Length:692 Species:Drosophila melanogaster
Sequence 2:NP_001277994.1 Gene:Foxa2 / 15376 MGIID:1347476 Length:465 Species:Mus musculus


Alignment Length:494 Identity:198/494 - (40%)
Similarity:254/494 - (51%) Gaps:109/494 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 SAYTMNSMGLPVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMSASM---------NASM 119
            |...||: ||.:.||::....:||.......:.:|...:||:.:.|.||.|:         .|.|
Mouse    33 SVSNMNA-GLGMNGMNTYMSMSAAAMGGGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGM 96

  Fly   120 NGSMGAAAMNSMGGNCMTPSSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREME 184
            :||.|||.:..||.: ::||.       ||||...               :|..|.:.|.: .|.
Mouse    97 SGSAGAAGVAGMGPH-LSPSL-------SPLGGQA---------------AGAMGGLAPYA-NMN 137

  Fly   185 TGSP--NSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFY 247
            :.||  ...|.||...|.||||||||||||||||||||||||.:|.:|||||||||:||||||||
Mouse   138 SMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFY 202

  Fly   248 RQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKE 312
            |||||||||||||||||||||:|:||:|||||||||||||||||||||||||||||||||.||:.
Mouse   203 RQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQL 267

  Fly   313 AIRQLHKSPSHSSLEATSPGKKDHE-----------DSHHMHHHHHSRLDHHQHHKEAGGASIAG 366
            |:::...:.| |..:.|:||.:..:           ::.......||.....|.||..|      
Mouse   268 ALKEAAGAAS-SGGKKTAPGSQASQAQLGEAAGSASETPAGTESPHSSASPCQEHKRGG------ 325

  Fly   367 VNVLSAAHSKDAEALAMLHANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDY 431
               ||......|.||:            .|:..|:...      ||:..:.::....||.|..:.
Mouse   326 ---LSELKGAPASALS------------PPEPAPSPGQ------QQQAAAHLLGPPHHPGLPPEA 369

  Fly   432 HSSMHPLKQEPSGYTPSSHPFSINRLLPTES------------KADIKMYD--MSQYAGYN---- 478
            |     ||  |..:...:||||||.|:.:|.            |.|:|.|:  |....||.    
Mouse   370 H-----LK--PEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGGYGSPMP 427

  Fly   479 ---ALSPLTN----SHAALGQD-SYYQSLGYHAPAGTTS 509
               |:.|:||    ..:.|..| ||||.: |..|...:|
Mouse   428 GSLAMGPVTNKAGLDASPLAADTSYYQGV-YSRPIMNSS 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fkhNP_001263038.1 Forkhead_N <120..209 CDD:254796 30/90 (33%)
FH 210..298 CDD:214627 79/87 (91%)
Foxa2NP_001277994.1 Forkhead_N 23..164 CDD:254796 48/155 (31%)
FH 165..253 CDD:214627 79/87 (91%)
DUF4799 <224..319 CDD:292674 46/95 (48%)
HNF_C 381..454 CDD:286443 23/72 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850130
Domainoid 1 1.000 175 1.000 Domainoid score I3637
eggNOG 1 0.900 - - E2759_KOG3563
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 271 1.000 Inparanoid score I2991
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 1 1.000 - - otm42941
orthoMCL 1 0.900 - - OOG6_105963
Panther 1 1.100 - - O PTHR11829
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4570
SonicParanoid 1 1.000 - - X1772
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.780

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