DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and Foxa1

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_032285.2	Gene:	Foxa1 / 15375	MGIID:	1347472	Length:	468	Species:	Mus musculus

Alignment Length:	504	Identity:	196/504 - (38%)
Similarity:	252/504 - (50%)	Gaps:	133/504 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 FSSSVLDSAAAVASMSASMSASMSASMNASMNGSMGAAAMNSM--GGNCMTPSS--MSYASMG-- 147
            ::|...|:..|.:|:..|...|...||| |||..|   .||:|  .|| |||:|  ||||:.|
Mouse    15 WNSYYADTQEAYSSVPVSNMNSGLGSMN-SMNTYM---TMNTMTTSGN-MTPASFNMSYANTGLG 74

  Fly   148 ---SP--LGNMGGCMAMSAASMSAAGLS-----------GTYGAMP--------PGSREME---- 184
               ||  :..|.|..|.:..||:|||::           |:.||.|        |.:..|.
Mouse    75 AGLSPGAVAGMPGASAGAMNSMTAAGVTAMGTALSPGGMGSMGAQPATSMNGLGPYAAAMNPCMS 139

  Fly   185 --TGSPNSLGRSRV---DKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLF 244
              ..:|::|||||.   ....|::|||.|||||||||||||||||..|::|||||||||:|||||
Mouse   140 PMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLF 204

  Fly   245 PFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDE 309
            |:||||||||||||||||||||||||:.|:||||||||:||||||||||||||||||||||||.|
Mouse   205 PYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCE 269

  Fly   310 KKEAI------------RQLHKSPSHSSLEATSPGKKDHEDSHHMHHHHHS-------------- 348
            |:...            .:..|.||       .||....|...|...|..:
Mouse   270 KQPGAGGGSGGGGSKGGPESRKDPS-------GPGNPSAESPLHRGVHGKASQLEGAPAPGPAAS 327

  Fly   349 --RLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAELCLSQQPQHVPTHHHHQHHQLQ 411
              .|||      :|..:..|.:.|.:..|..|..:    ::....|:..|   |:|..|.
Mouse   328 PQTLDH------SGATATGGASELKSPASSSAPPI----SSGPGALASVP---PSHPAHG----- 374

  Fly   412 QEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSINRLLPT---ESKADIKMYDMS- 472
                            :..:.|.:| ||.:|  :...:||||||.|:.:   :.|.|.|.|:.:
Mouse   375 ----------------LAPHESQLH-LKGDP--HYSFNHPFSINNLMSSSEQQHKLDFKAYEQAL 420

  Fly   473 QYAGYNALSP--LTNSHAALG----------QDSYYQSLGYHAPAGTTS 509
            ||:.|.|..|  |....|::.          :.:|||.: |..|...||
Mouse   421 QYSPYGATLPASLPLGSASVATRSPIEPSALEPAYYQGV-YSRPVLNTS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	42/127 (33%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	77/87 (89%)
Foxa1	NP_032285.2	Forkhead_N	17..169	CDD:369872	53/156 (34%)
		FH	170..258	CDD:214627	77/87 (89%)
		Essential for DNA binding	251..288		19/36 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..396		29/170 (17%)
		HNF_C	394..457	CDD:370449	19/62 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3637
eggNOG	1	0.900	-	-		E2759_KOG3563
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2991
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1181467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42941
orthoMCL	1	0.900	-	-		OOG6_105963
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4570
SonicParanoid	1	1.000	-	-		X1772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860