Protein Alignment fkh and Foxg1

DIOPT Version :9

• Sequence 1: NP_001263038.1
• Gene: fkh / 43383
• FlyBaseID: FBgn0000659
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_001153584.1
• Gene: Foxg1 / 15228
• MGIID: 1347464
• Length: 481
• Species: Mus musculus
• Alignment Length: 542
• Identity: 145/542 - (26%)
• Similarity: 192/542 - (35%)
• Gaps: 179/542 - (33%)

  Fly     9 PPSSAPVSMASSGGGGPPSGGGGGGGGGGGGGPPPPSNNNPNPTSNGGSMSPLARSAYTMNSMGL 73
            ||..||         .||              ||||......|..  ....|.||        |.
Mouse    57 PPPPAP---------QPP--------------PPPPQQQQQQPPP--APQPPQAR--------GA 88

  Fly    74 PVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMSASMNASMNGSMGAAAMNSMGGNCMTP 138
            |... ....||......|:.||.|.|.|                       ..|....||.   |
Mouse    89 PAAD-DDKGPQPLLLPPSTALDGAKADA-----------------------LGAKGEPGGG---P 126

  Fly   139 SSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYR 203
            :.:  |.:|......|               :|..|....|:.|   |..:..|....||
Mouse   127 AEL--APVGPDEKEKG---------------AGAGGEEKKGAGE---GGKDGEGGKEGDK----- 166

  Fly   204 RSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCF 268
            ::..:.|||:||.:||.|||:.:|.:.|||:.||:|||..||:||:|:|.|||||||:||.|.||
Mouse   167 KNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCF 231

  Fly   269 VKIPRTPDKPGKGSFWTLHPDSGNMFENGC--YLRRQ---KRFKDEKKEAIR------------- 315
            ||:||..|.||||::|.|.|.|.::|..|.  .|||:   .|.|...|...|
Mouse   232 VKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAG 296

  Fly   316 ----------QLHKSPSHSSLEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVL 370
                      .||...:.|:|...  |......||.|.:                 :|:...|.|
Mouse   297 SLYWPMSPFLSLHHPRASSTLSYN--GTTSAYPSHPMPY-----------------SSVLTQNSL 342

  Fly   371 SAAHS-KDAEALAMLH-ANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHS 433
            ...|| ..|..|::.. .|.|         :|...||    |....|:|.:.  |..|:
Mouse   343 GNNHSFSTANGLSVDRLVNGE---------IPYATHH----LTAAALAASVP--CGLSV------ 386

  Fly   434 SMHPLKQEPSGYTPSSHPFSINRL----------LPTESKADIKMYDMSQYAGYNALSPLTNSHA 488
                    |...|.|.:|.|:|.|          :|..|........||..|..::.||  .:.:
Mouse   387 --------PCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTSQTSTSMSARAASSSTSP--QAPS 441

  Fly   489 ALGQDSYYQSLGYHAPAGTTSL 510
            .|..:|...||    |:.||.|
Mouse   442 TLPCESLRPSL----PSFTTGL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	15/88 (17%)
		FH	210..298	CDD:214627	51/87 (59%)
Foxg1	NP_001153584.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..173		39/200 (20%)
		FH	173..261	CDD:214627	51/87 (59%)
		Required for interaction with TLE6. /evidence=ECO:0000269|PubMed:16314515	241..336		25/113 (22%)
		Interaction with KDM5B. /evidence=ECO:0000250	375..398		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447		6/29 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910