DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and Foxd3

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_034555.3	Gene:	Foxd3 / 15221	MGIID:	1347473	Length:	469	Species:	Mus musculus

Alignment Length:	549	Identity:	157/549 - (28%)
Similarity:	207/549 - (37%)	Gaps:	181/549 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 GSPL--GNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYRRSYTHA 209
            |:|.  |..||..|::......|| ||..|.:.|...:      |||                 .
Mouse    90 GAPEADGCKGGEDAVTGGGGPGAG-SGATGGLTPNKPK------NSL-----------------V 130

  Fly   210 KPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRT 274
            |||||||:||||||..:|.:.||||.|.:||.:.||:||:....|||||||:||.|||||||||.
Mouse   131 KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPRE 195

  Fly   275 PDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQ----LHKSPSHSSLEATSPGKKD 335
            |..||||::|||.|.|.:||:||.:|||:||||..::|.:|:    :.:|....|| |.:.|...
Mouse   196 PGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSL-AAAAGAGP 259

  Fly   336 HEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAELCLSQQPQHVP 400
            :...:.:|                 .|:.||      |:|..|.|.|...|.|    .|.|..:|
Mouse   260 YGRPYGLH-----------------PAAAAG------AYSHPAAAAAAAAAAA----LQYPYALP 297

  Fly   401 THHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSINRLLPTESKAD 465
            .                 :|....|::         ||.  |||        .:.|
Mouse   298 P-----------------VAPVLPPAV---------PLL--PSG--------ELGR--------- 317

  Fly   466 IKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSLXHHQYPLAXGRAEQMLRSQQ 530
             |........|.:....|....||..      :.|....||||||.
Mouse   318 -KAAAFGSQLGPSLQLQLNTLGAAAA------AAGTAGAAGTTSLI------------------- 356

  Fly   531 QQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLTSASNTPATSAKASGKAGSASASGSGSGSGS 595
                                     :.:.||:...|..|.....:.|.|  |||...|||.|:|.
Mouse   357 -------------------------KSEPSARPSFSIENIIGAGSAAPG--GSAGGGGSGGGAGG 394

  Fly   596 GSGSNYSQKLQQQHQQQQQQQAAAQQQHHQQQQQLLQELQEDSSNITSDLSEEQLQQHQAAQQQL 660
            |.||......|...:.....|:||....||.     ..|...::.|...||           ..|
Mouse   395 GGGSGGGGGAQSFLRPPGTVQSAALMATHQP-----LSLSRTTATIAPILS-----------VPL 443

  Fly   661 YNNYQQYAAAAGYRNWNHGLAFNGAAALQ 689
            ...:.|.||:|         |...|||:|
Mouse   444 SGQFLQPAASA---------AAAAAAAVQ 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	15/63 (24%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	56/87 (64%)
Foxd3	NP_034555.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		12/43 (28%)
		Forkhead	131..217	CDD:278670	55/85 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..409		13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910