DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and Foxb2

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_032049.1	Gene:	Foxb2 / 14240	MGIID:	1347468	Length:	428	Species:	Mus musculus

Alignment Length:	341	Identity:	124/341 - (36%)
Similarity:	168/341 - (49%)	Gaps:	44/341 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 PTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLS 263
            |...:.||:..|||||||||..||||::..:||.||:||:|||:.||:||::.||||||:||:||
Mouse     2 PRPGKSSYSDQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQRWQNSLRHNLS 66

  Fly   264 FNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLH---KSPSHSS 325
            |||||:||||.||:|||||||.||||.|:|||||.:|||:||||     .:|..|   .|.|...
Mouse    67 FNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSFLRRRKRFK-----VLRADHAHLHSGSSKG 126

  Fly   326 LEATSPGKKDH----EDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHA 386
            ...|.||...|    ..:||.|||||....||.||...........:::...|.:.|.|....|.
Mouse   127 APGTGPGGHLHPHHPHHAHHHHHHHHHAAHHHHHHHPPQPPPPPPPHMVPYFHQQPAPAPQPPHL 191

  Fly   387 NAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEP--------- 442
            .::.....|||..|....|.....:...::|..|.....::     .|:..|.|.|
Mouse   192 PSQPAQQPQPQSQPPQTSHPGKMQEAAAVAAAAAAAAAAAV-----GSVGRLSQFPPYGLGSAAA 251

  Fly   443 ------SGYTPSSHPFSINRLLPTESK-----ADIKMYDMSQYAGYNALSPLTN------SHAAL 490
                  :..|...|||:|..::..:.|     ..:.:..:..:.||.....|:|      .|..:
Mouse   252 AAAAAAASTTGFKHPFAIENIIGRDYKGVLQAGGLPLASVMHHLGYPVPGQLSNVVGSVWPHVGV 316

  Fly   491 GQDSYYQSLGYHAPAG 506
             .||...:....|.||
Mouse   317 -MDSVAAAAAAAAAAG 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	3/9 (33%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	63/87 (72%)
Foxb2	NP_032049.1	FH	13..101	CDD:214627	63/87 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..217		26/98 (27%)
		E_Pc_C	<342..>406	CDD:284226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910