Protein Alignment mIF2 and infB

DIOPT Version :10

• Sequence 1: NP_651621.2
• Gene: mIF2 / 43382
• FlyBaseID: FBgn0039588
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_417637.1
• Gene: infB / 947684
• ECOCYCID: EG10505
• Length: 890
• Species: Escherichia coli
• Alignment Length: 694
• Identity: 263/694 - (37%)
• Similarity: 385/694 - (55%)
• Gaps: 98/694 - (14%)

  Fly    34 HVSAARLKRRKTAEEKKSPRIIEYSPKKFQTAGGGASD--------------------IWRHMTV 78
            :..|||.|:.....|.|:.|  |.:....:...||...                    |...:||
E. coli   256 NAKAARPKKGNKHAESKADR--EEARAAVRGGKGGKRKGSSLQQGFQKPAQAVNRDVVIGETITV 318

  Fly    79 AQLAKELERSLDDVQEAMLYVKGADNIEPAFKLA---------DLKIIQEIAKKLGAKTRVVATP 134
            .:||.::.            |||:..|:...||.         |.:..|.:|:::|.|. ::...
E. coli   319 GELANKMA------------VKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKV-ILRRE 370

  Fly   135 EETNADEQKERDVAPRPPAAPELLQPRPPVVTVMGHVDHGKTTLLDSLRGADVAAGEAGGITQHI 199
            .|.......:||..    ||.|   ||.||||:|||||||||:|||.:|...||:||||||||||
E. coli   371 NELEEAVMSDRDTG----AAAE---PRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHI 428

  Fly   200 GAFTVTLENGERVTFLDTPGHAAFSAMRARGAVATDIIVLVVAAEDGVMAQTREVIQLAKEAQVP 264
            ||:.|..||| .:|||||||||||::||||||.||||:||||||:||||.||.|.||.||.||||
E. coli   429 GAYHVETENG-MITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAQVP 492

  Fly   265 IIVALNKIDKPEANIEKSKRELAQMGLALEEHGGDVQVIPISALKGTNLELLAEAVSTQATLMGL 329
            ::||:||||||||:.::.|.||:|.|:..||.||:.|.:.:||..||.::.|.:|:..||.::.|
E. coli   493 VVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLEL 557

  Fly   330 KADPTGLVEGIVVESKTDPRRGKLSTAIVSRGTLRKGSVLLSGLAHAKVRGLFDHNGQPLSEAPP 394
            ||...|:..|.|:||..|..||.::|.:|..|||.||.::|.|..:.:||.:.:..||.:.||.|
E. coli   558 KAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGP 622

  Fly   395 GTPVEILGWRELPLAGDLILEVETEKKAHAVLKYREHESQQEKIESSSDEIRKKEEEHQAKYRAE 459
            ..||||||...:|.|||.:..|..||||..|..||:.:.::.|:                   |.
E. coli   623 SIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKL-------------------AR 668

  Fly   460 REARRLAGRFRMRGGQRVKQVDENEGK-PRVSVIIKGDVHGSVEAILDVLETYNSNESCRLDIVH 523
            ::..:|...|          .:..||: ..|::::|.||.||||||.|.|...:::| .::.|:.
E. coli   669 QQKSKLENMF----------ANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDE-VKVKIIG 722

  Fly   524 YGVGNVTEGDLELAKAFHAIIYAFAVETP----QLKAAKEVNIRSYNIIYRLIDDLKEQLSSKLP 584
            .|||.:||.|..||.|.:||:..|.|...    ::..|:.:::|.|::||.|||::|..:|..|.
E. coli   723 SGVGGITETDATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAAMSGMLS 787

  Fly   585 PVEVEEVLGEANVLQNFLINEGRKEVPVAGCRCTKGVLKKAQKFRLLRDGEVVYDGPLESMRHLK 649
            |...::::|.|.|...|   :..|...:|||..|:||:|:....|:|||..|:|:|.|||:|..|
E. coli   788 PELKQQIIGLAEVRDVF---KSPKFGAIAGCMVTEGVVKRHNPIRVLRDNVVIYEGELESLRRFK 849

  Fly   650 NEVDTIKKDVECGL---RFRDTKVLPQAGDILQCYTTKMEAQQT 690
            ::|:.::..:|||:   .:.|.:    .||:::.:.. :|.|:|
E. coli   850 DDVNEVRNGMECGIGVKNYNDVR----TGDVIEVFEI-IEIQRT 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	159..688	CDD:440298	229/536 (43%)
infB	NP_417637.1	PTZ00121	<19..>281	CDD:173412	8/26 (31%)
		IF2_assoc	56..94	CDD:429947
		IF2_N	314..364	CDD:428110	14/61 (23%)
		InfB	388..889	CDD:440298	232/543 (43%)