Protein Alignment mIF2 and IFM1

DIOPT Version :10

• Sequence 1: NP_651621.2
• Gene: mIF2 / 43382
• FlyBaseID: FBgn0039588
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_014619.1
• Gene: IFM1 / 854135
• SGDID: S000005383
• Length: 676
• Species: Saccharomyces cerevisiae
• Alignment Length: 676
• Identity: 232/676 - (34%)
• Similarity: 374/676 - (55%)
• Gaps: 78/676 - (11%)

  Fly    14 LHFSRAVTQWQLPLAFQREFHVSAARLKRRKTAEEKKSPRIIEYSPKKFQTAGGGASDIWRHMTV 78
            || ||.:.|       ||.:    |:.|||....:|      |..|..|        .|..:::|
Yeast    30 LH-SRDICQ-------QRWY----AKGKRRNQISKK------ELKPLNF--------SIPNYISV 68

  Fly    79 AQLAK----ELERSLDDVQEAMLYVKGADNIEPAFKLADLKIIQEIAKKLGAKTRVVATPEETNA 139
            .:||.    .:||.:.|     |...|.:||...:.|:. :.::.|.::.......::|  .||.
Yeast    69 NKLANLLNCRVERLIKD-----LTALGFENITTTYILSK-EYVELILQEYNFALPNLST--STNL 125

  Fly   140 DEQKERDVAPRPPAAPELLQPRPPVVTVMGHVDHGKTTLLDSLRGADVAAGEAGGITQHIGAFTV 204
            |...:.   .:.|..|:||..|.||||:||||||||||::|.||.:.|.|.|.||||||||||.:
Yeast   126 DNVYDE---LKSPVNPKLLTKRAPVVTIMGHVDHGKTTIIDYLRKSSVVAQEHGGITQHIGAFQI 187

  Fly   205 TL-ENGERVTFLDTPGHAAFSAMRARGAVATDIIVLVVAAEDGVMAQTREVIQLAKEAQVPIIVA 268
            |. ::|:::|||||||||||..||.|||..||||||||:.||.:|.||.|.|:.||.:...:|:|
Yeast   188 TAPKSGKKITFLDTPGHAAFLKMRERGANITDIIVLVVSVEDSLMPQTLEAIKHAKNSGNEMIIA 252

  Fly   269 LNKIDK------PEANIEKSKRELAQMGLALEEHGGDVQVIPISALKGTNLELLAEAVSTQATLM 327
            :.|||:      .|..|||...:|...|:.:|:.|||||||||||..|.|::||.|::...:.:|
Yeast   253 ITKIDRIPQPKEREKKIEKVINDLIVQGIPVEKIGGDVQVIPISAKTGENMDLLEESIVLLSEVM 317

  Fly   328 GLKAD--PTGLVEGIVVESKTDPRRGKLSTAIVSRGTLRKGSVLLSGLAHAKVRGLFDHNGQPLS 390
            .::|:  |..:.||.::||:...:.|.::|.:|.:|||:||.:|:.|....|::.|.|..|.|:.
Yeast   318 DIRAENSPKTIAEGWIIESQVKKQVGNVATVLVKKGTLQKGKILICGNTFCKIKNLIDDKGIPIL 382

  Fly   391 EAPPGTPVEILGWRELPLAGDLILEVETEKKAHAVLKYREHESQQEK----IESSSDEIRKKEEE 451
            :|.|....|:|||:::|..||.:::|::|..|...:..|:...:.:|    :|..::|....:|:
Yeast   383 KATPSYATEVLGWKDVPHVGDEVIQVKSEAIAKKFISKRQDLIEVQKNSSIVEKLNEERALAKEQ 447

  Fly   452 HQAKYRAEREARRLAGRFRMRGGQRVKQVDENEGKPRVSVIIKGDVHGSVEAILDVLETYNSNES 516
            |..| ..|.|             ..|::.::|.|...::.|||.||.||.||:.:.:.:. .|:.
Yeast   448 HLNK-ELEHE-------------NTVQEHEQNTGPKLINYIIKCDVSGSAEAVSESISSL-GNDE 497

  Fly   517 CRLDIVHYGVGNVTEGDLELAKAFHAIIYAFAV-----ETPQLKAAKEVNIRSYNIIYRLIDDLK 576
            .|.:::...||..||.||::|:...:.|..|.:     |....:|.  :.|:.||:||:||:|:.
Yeast   498 VRCNVISSSVGIPTESDLKMAQITESTILCFNLGNLPSEVINNRAG--IKIKQYNVIYKLIEDVT 560

  Fly   577 EQLSSKLPPVEVEEVLGEANVLQNFLINEGRKEVPVAGCRCTKGVLKKAQKFRLLR--DGEVVYD 639
            |.|:..|.|:..::::...:|.:.|.....:|.:.:|||:...||:||....:::|  :.:|::|
Yeast   561 ETLTENLKPIFEKKIVSTVDVRETFDFRLKKKIIRIAGCKVNNGVIKKNSLVQVVRGPNEDVIFD 625

  Fly   640 GPLESMRHLKNEVDTIKKDVECGLRF 665
            |.:.:::|.|::|..:.|..|||:.|
Yeast   626 GKISTLKHNKDDVAEVSKGHECGITF 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	159..688	CDD:440298	196/527 (37%)
IFM1	NP_014619.1	IF2_N	63..114	CDD:428110	12/56 (21%)
		InfB	143..676	CDD:440298	196/526 (37%)