Protein Alignment mIF2 and FUN12

DIOPT Version :10

• Sequence 1: NP_651621.2
• Gene: mIF2 / 43382
• FlyBaseID: FBgn0039588
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_009365.1
• Gene: FUN12 / 851196
• SGDID: S000000033
• Length: 1002
• Species: Saccharomyces cerevisiae
• Alignment Length: 713
• Identity: 179/713 - (25%)
• Similarity: 275/713 - (38%)
• Gaps: 214/713 - (30%)

  Fly    30 QREFHVSAARLKRRKTAEEKK----------------------------SPRIIEYSPKKFQTAG 66
            :||...:..:|..||..||||                            .|:.:.||.||.:|..
Yeast   226 KREKRKAEGKLLTRKQKEEKKLLERRRAALLSSGNVKVAGLAKKDGEENKPKKVVYSKKKKRTTQ 290

  Fly    67 GGASDIWRHMTVAQLAK---------ELERS----LDDVQEAMLYVKGADNIEPAFKLADLKIIQ 118
            ..||:     .:...:|         ||:.|    :||.:...|   |.|:.|     ...:..|
Yeast   291 ENASE-----AIKSDSKKDSEVVPDDELKESEDVLIDDWENLAL---GDDDEE-----GTNEETQ 342

  Fly   119 EIAKKLGAKTRVVATPEETNADEQKE-------RDVAPRPPAAPELLQPRP------------PV 164
            |.......:.:.....||...:|::|       .:||...|||.....|.|            |:
Yeast   343 ESTASHENEDQNQGEEEEEGEEEEEEEEERAHVHEVAKSTPAATPAATPTPSSASPNKKDLRSPI 407

  Fly   165 VTVMGHVDHGKTTLLDSLRGADVAAGEAGGITQHIGAF----------TVTLENGERVTF----- 214
            ..::||||.|||.|||.:|..:|..||||||||.|||.          |..:...|:.||
Yeast   408 CCILGHVDTGKTKLLDKIRQTNVQGGEAGGITQQIGATYFPIDAIKAKTKVMAEYEKQTFDVPGL 472

  Fly   215 --LDTPGHAAFSAMRARGAVATDIIVLVVAAEDGVMAQTREVIQLAKEAQVPIIVALNKIDK--- 274
              :|||||.:||.:|:||:...:|.:||:....|:..||.|.|:|.::.:.|.:|||||||:
Yeast   473 LVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQTIESIKLLRDRKAPFVVALNKIDRLYD 537

  Fly   275 ----P-------------------EANIEKSKRELAQMGLALEEHGGD------VQVIPISALKG 310
                |                   ::...|.:.|||:.||..|.:..:      |.::|.||:.|
Yeast   538 WKAIPNNSFRDSFAKQSRAVQEEFQSRYSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTG 602

  Fly   311 TN--------LELLAEAVSTQATLMGLKADPTGLVEGIVVESKTDPRRGKLSTAIVSRGTLRKGS 367
            ..        |||..:.:|.|  ||.|..     ||..::|.|.....|.....|:|.|.||:|.
Yeast   603 EGVPDLLWLLLELTQKRMSKQ--LMYLSH-----VEATILEVKVVEGFGTTIDVILSNGYLREGD 660

  Fly   368 -VLLSGL---AHAKVRGLFDHNGQPLSEAPPGTPVEILGWRELPLAGDLILEVETEKKAHAVLKY 428
             ::|.|:   ....:|.|.  ..|||              |||.|..:.:    ..|:..|.|..
Yeast   661 RIVLCGMNGPIVTNIRALL--TPQPL--------------RELRLKSEYV----HHKEVKAALGV 705

  Fly   429 REHESQQEKIESSSD--EIRKKEEEHQAKYRAEREARRLAGRFRMRGGQRVKQVDENEGKPRVSV 491
            :...:..||..|.|.  .:..:::|.:.......:...|           :..|| ..||   .|
Yeast   706 KIAANDLEKAVSGSRLLVVGPEDDEDELMDDVMDDLTGL-----------LDSVD-TTGK---GV 755

  Fly   492 IIKGDVHGSVEAILDVLETYNSNESCRLDIVHYGVGNVTEGDLELAKAF------HAIIYAFAV- 549
            :::....||:||:||.|      :..::.::..|:|.|.:.|:..|...      :|::..|.|
Yeast   756 VVQASTLGSLEALLDFL------KDMKIPVMSIGLGPVYKRDVMKASTMLEKAPEYAVMLCFDVK 814

  Fly   550 ---ETPQLKAAKEVNIRSYNIIYRLIDDLKEQLSSKLPPVEVEEVLGEANVLQNFLINEGRKE 609
               |..|....:.:.|.:.::||.|.|..                    ...|..|:.|.||:
Yeast   815 VDKEAEQYAEQEGIKIFNADVIYHLFDSF--------------------TAYQEKLLEERRKD 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	159..688	CDD:440298	141/536 (26%)
FUN12	NP_009365.1	PRK04004	400..964	CDD:457675	139/526 (26%)