DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mIF2 and AT1G76810

DIOPT Version :9

Sequence 1:	NP_651621.2	Gene:	mIF2 / 43382	FlyBaseID:	FBgn0039588	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_177807.3	Gene:	AT1G76810 / 844015	AraportID:	AT1G76810	Length:	1294	Species:	Arabidopsis thaliana

Alignment Length:	684	Identity:	169/684 - (24%)
Similarity:	258/684 - (37%)	Gaps:	190/684 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 DDVQEAMLYVK--------GADNIEPAFKLADLKIIQEIAKKLGAK----TRVVATPEETNADEQ 142
            |:.:||...||        .|.:.||..:       :..||..|..    ..|.||||..:|...
plant   618 DEEEEAQPVVKKELKDAISKAHDSEPEAE-------KPTAKPAGTGKPLIAAVKATPEVEDATRT 675

  Fly   143 KERDVAPRPPAAPELLQP----------RPPVVTVMGHVDHGKTTLLDSLRGADVAAGEAGGITQ 197
            |....|.......:.|.|          |.|:..:|||||.|||.|||.:||.:|..||||||||
plant   676 KRATRAKDASKKGKGLAPSESIEGEENLRSPICCIMGHVDTGKTKLLDCIRGTNVQEGEAGGITQ 740

  Fly   198 HIGAFTVTLEN-GER--------------VTFLDTPGHAAFSAMRARGAVATDIIVLVVAAEDGV 247
            .|||.....|| .||              :..:|||||.:|:.:|:||:...|:.:|||....|:
plant   741 QIGATYFPAENIRERTKELKADAKLKVPGLLVIDTPGHESFTNLRSRGSSLCDLAILVVDIMHGL 805

  Fly   248 MAQTREVIQLAKEAQVPIIVALNKIDK-------PEANIEKSKR-------------------EL 286
            ..||.|.:.|.:......||||||:|:       ..|.|.|:.:                   |.
plant   806 EPQTIESLNLLRMRNTEFIVALNKVDRLYGWKTCKNAPIVKAMKQQNKDVINEFNLRLKNIINEF 870

  Fly   287 AQMGLALE------EHGGDVQVIPISALKGTNL-ELLAEAVSTQATLMGLKADPTGLVEGIVVES 344
            .:.||..|      :.|....::|.||:.|..: :||...|......|..|......|:..|:|.
plant   871 QEQGLNTELYYKNKDMGDTFSIVPTSAISGEGVPDLLLWLVQWAQKTMVEKLTYVDEVQCTVLEV 935

  Fly   345 KTDPRRGKLSTAIVSRGTLRKG-SVLLSGL-----------------AHAKVRGLFDH------- 384
            |.....|.....::..|.|.:| .:::.||                 ...:|:|.:.|
plant   936 KVIEGHGTTIDVVLVNGELHEGDQIVVCGLQGPIVTTIRALLTPHPMKELRVKGTYLHYKEIKAA 1000

  Fly   385 -----NGQPLSEAPPGTPVEILGWRELPLAGDLILEVETEKKAHAVLKYREHESQQEKIESSSDE 444
                 ..|.|..|..||.:.::|..:         ::|..|           ||..|.:||....
plant  1001 QGIKITAQGLEHAIAGTALHVVGPDD---------DIEAIK-----------ESAMEDMESVLSR 1045

  Fly   445 IRKKEEEHQAKYRAEREARRLAGRFRMRGGQRVKQVDENEGKPRVSVIIKGDVHGSVEAILDVLE 509
            |.|..|                                       .|.::....||:||:|:
plant  1046 IDKSGE---------------------------------------GVYVQASTLGSLEALLE--- 1068

  Fly   510 TYNSNESCRLDIVHYGVGNVTEGDLELA------KAFHAIIYAFAVE--TPQLKAAKEVNIRSY- 565
             |..:.:.::.:...|:|.|.:.|:..|      |..:|.|.||.|:  |...:.|.|:.::.:
plant  1069 -YLKSPAVKIPVSGIGIGPVHKKDVMKAGVMLERKKEYATILAFDVKVTTEARELADEMGVKIFC 1132

  Fly   566 -NIIYRLIDDLKEQLSSKLPPVEVEEVLGEA------NVLQNFLINEGRKEVPVAGCRCTKGVLK 623
             :|||.|.|..|..:.: :...:.:|...||      .:|.|.:.|  :|:..|.|....:|:||
plant  1133 ADIIYHLFDLFKAYIEN-IKEEKKKESADEAVFPCVLQILPNCVFN--KKDPIVLGVDVIEGILK 1194

  Fly   624 KAQKFRLLRDGEVVYDGPLESMRHLKNEVDTIKK 657
            ..... .:...|.:..|.:.|:.:....||..||
plant  1195 IGTPI-CVPGREFIDIGRIASIENNHKPVDYAKK 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	158..689	CDD:223606	150/604 (25%)
		IF2_eIF5B	163..327	CDD:206674	70/211 (33%)
		IF2_mtIF2_II	336..431	CDD:293903	21/124 (17%)
		IF-2	482..575	CDD:288813	26/102 (25%)
		mtIF2_IVc	593..680	CDD:293893	18/71 (25%)
AT1G76810	NP_177807.3	PRK04004	700..1294	CDD:235195	148/595 (25%)
		IF2_eIF5B	706..916	CDD:206674	70/209 (33%)
		aeIF5B_II	927..1037	CDD:293904	23/129 (18%)
		IF-2	1040..1141	CDD:288813	30/143 (21%)
		IF2_aeIF5B_IV	1166..1260	CDD:293911	16/65 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1124591at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820