DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mIF2 and Mtif2

DIOPT Version :9

Sequence 1:	NP_651621.2	Gene:	mIF2 / 43382	FlyBaseID:	FBgn0039588	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_001269048.1	Gene:	Mtif2 / 76784	MGIID:	1924034	Length:	746	Species:	Mus musculus

Alignment Length:	703	Identity:	326/703 - (46%)
Similarity:	458/703 - (65%)	Gaps:	34/703 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FSRAVTQWQLPL---AFQREFHVSAARLKRR--KTAEEKKSPRIIEYSPKKFQTAGGGASDIWRH 75
            |:.|.:.|:..|   ::|.:..:.:|..:.|  .|.:||:.|| .:.||.|.:.    ..::|..
Mouse    56 FAPASSVWRDLLGARSWQTDMLIGSALHQHRLLVTKKEKRPPR-SQLSPVKTKK----EVEVWVG 115

  Fly    76 MTVAQLAKELERSLDDVQEAMLYVK-GADNIEPAFKLADLKIIQEIAKKLGAKTRVVATPEETNA 139
            |||..||..:.:.:|.|.||:|... ..|::|....| |...|:|:.||.|.|.:.....:|.
Mouse   116 MTVEDLASAMAKDIDCVYEALLNTAIDVDSLEANSHL-DEVWIKEVIKKAGMKLKWSKLKQER-- 177

  Fly   140 DEQKERDVAPRPPAAPELLQPRPPVVTVMGHVDHGKTTLLDSLRGADVAAGEAGGITQHIGAFTV 204
             .::.:|...||...|.||:||.||||||||||||||||||.||...|||.|.||||||||||.|
Mouse   178 -IRENKDAVRRPGTDPALLKPRSPVVTVMGHVDHGKTTLLDKLRETQVAAMEVGGITQHIGAFLV 241

  Fly   205 TLENGERVTFLDTPGHAAFSAMRARGAVATDIIVLVVAAEDGVMAQTREVIQLAKEAQVPIIVAL 269
            :|.:||::|||||||||||||||||||..|||:||||||:||||.||.|.||.||:|:||||:|:
Mouse   242 SLPSGEKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAEVPIILAI 306

  Fly   270 NKIDKPEANIEKSKRELAQMGLALEEHGGDVQVIPISALKGTNLELLAEAVSTQATLMGLKADPT 334
            ||.||.:|:.||.|:||....:..||:|||||.:.:|||.|.||..||||....|.::.||||||
Mouse   307 NKCDKTDADPEKVKKELLAYDVVCEEYGGDVQAVHVSALTGDNLMALAEATIALAEILELKADPT 371

  Fly   335 GLVEGIVVESKTDPRRGKLSTAIVSRGTLRKGSVLLSGLAHAKVRGLFDHNGQPLSEAPPGTPVE 399
            |.|||.|:||.||..||.::|||:.||||||||:|::|.:.||||.:||.||:.|:||.|..||.
Mouse   372 GPVEGTVIESFTDKGRGPVTTAIIQRGTLRKGSILVAGKSWAKVRLIFDENGKILNEAYPSMPVG 436

  Fly   400 ILGWRELPLAGDLILEVETEKKAHAVLKYREHESQQEKIESSSDEIRKKEEEHQAKYRAEREARR 464
            |:|||:||.|||.|||||:|.:|..|:::|:.|.::||   ..|:::..||:.:....|.|:||.
Mouse   437 IIGWRDLPSAGDEILEVESEPRAREVIEWRKSEQKEEK---GKDDLKIMEEKRREHQEAHRKARE 498

  Fly   465 LAGRFRMRGGQRVKQVDENEGKPR------------VSVIIKGDVHGSVEAILDVLETYNSNESC 517
            ..|....:....:|.::..:.:|.            :.:||||||.|||||||::|:||:::..|
Mouse   499 KYGSLHWKERSYIKFLERKQQRPLKPKEKVERQSNVLPIIIKGDVDGSVEAILNLLDTYDASHEC 563

  Fly   518 RLDIVHYGVGNVTEGDLELAKAFHAIIYAFAVET----PQLKAAKEVNIRSYNIIYRLIDDLKEQ 578
            .|::||:|:|:::|.|:..|:.|..:||.|.||.    .|..|.|.|.|:.:.|||.||:||:|:
Mouse   564 ELELVHFGLGDISENDVTFAETFDGVIYGFNVEAGSAIQQSAAQKGVKIKLHKIIYHLIEDLQEE 628

  Fly   579 LSSKLPPVEVEEVLGEANVLQNFLINEGRKEVPVAGCRCTKGVLKKAQKFRLLRDGEVVYDGPLE 643
            |||:||....|..:|||::|..|.:.||:|::||||||..||.|::.:||:|:|:|:|::.|.|.
Mouse   629 LSSRLPHTLEEYPIGEASILATFTVTEGKKKIPVAGCRVQKGQLERHKKFKLIRNGQVIWKGSLT 693

  Fly   644 SMRHLKNEVDTIKKDVECGLRFRDTKVLPQAGDILQCYTTKMEAQQTDWDPGF 696
            |::|.|:::..||..::|||...:.||..:.||.:.||.......:|.|||||
Mouse   694 SLKHHKDDISVIKTGMDCGLSLDEEKVEFKPGDQVICYEENKVPTKTSWDPGF 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	158..689	CDD:223606	278/546 (51%)
		IF2_eIF5B	163..327	CDD:206674	111/163 (68%)
		IF2_mtIF2_II	336..431	CDD:293903	55/94 (59%)
		IF-2	482..575	CDD:288813	42/108 (39%)
		mtIF2_IVc	593..680	CDD:293893	37/86 (43%)
Mtif2	NP_001269048.1	InfB	195..737	CDD:223606	278/544 (51%)
		IF2_eIF5B	200..364	CDD:206674	111/163 (68%)
		IF2_mtIF2_II	373..467	CDD:293903	54/93 (58%)
		IF-2	534..625	CDD:288813	41/90 (46%)
		mtIF2_IVc	643..730	CDD:293893	37/86 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832982
Domainoid	1	1.000	209	1.000	Domainoid score	I2844
eggNOG	1	0.900	-	-		E1_COG0532
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1840
Inparanoid	1	1.050	580	1.000	Inparanoid score	I1018
Isobase	1	0.950	-	0	Normalized mean entropy	S1351
OMA	1	1.010	-	-		QHG56520
OrthoDB	1	1.010	-	-		D1124591at2759
OrthoFinder	1	1.000	-	-		FOG0004112
OrthoInspector	1	1.000	-	-		oto92928
orthoMCL	1	0.900	-	-		OOG6_100987
Panther	1	1.100	-	-	LDO	PTHR43381
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2379
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.720