DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mIF2 and CG4849

DIOPT Version :9

Sequence 1:	NP_651621.2	Gene:	mIF2 / 43382	FlyBaseID:	FBgn0039588	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	814	Identity:	152/814 - (18%)
Similarity:	256/814 - (31%)	Gaps:	304/814 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EEKKSPRII-----EYSPKKFQTAGGGASDIWRHMTVAQLAKELERSLDDVQEAMLYVKGADNIE 106
            |:|:...::     .|.|...:..|.....|.:......|.|.|                   ||
  Fly    52 EDKEVTAVVLHEDKRYYPSAVEVYGPDVETIVQEEDAQPLDKPL-------------------IE 97

  Fly   107 PAFKLADLKIIQEIAKKLGAKTRVVATPEETNADEQKERDVAPRPPAAPELLQPRPPVVTVMGHV 171
            |..||           |...|.:.:   :||..|.:...|:...||....        |.::||:
  Fly    98 PVKKL-----------KFQIKEQDM---QETTYDMEFMADLMDTPPLIRN--------VALVGHL 140

  Fly   172 DHGKTTLLDSL---------------------------RGADVAAGEAGGITQHIGAFTVTLENG 209
            .|||||.:|.|                           ||..:.|...          |:.|::.
  Fly   141 HHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERGCSIKATPV----------TLVLQDV 195

  Fly   210 ERVTFL----DTPGHAAFSAMRARGAVATDIIVLVVAAEDGVMAQTREVIQLAKEAQVPIIVALN 270
            ::.::|    |||||..||.........:|.:||.:.|.:|||..|..:::.|.:.:..|.|.:|
  Fly   196 KQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAITVCIN 260

  Fly   271 KIDK--------PEANIEKSKRELAQMGLALEEHGG---DVQVIPI-------SALKGTNLELLA 317
            |||:        |:....|.|..:.::...|..:|.   ::.|.||       |:|.|....|.:
  Fly   261 KIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFASSLYGFCFTLKS 325

  Fly   318 EAVSTQATLMGL-----------------------KADPTGLVEGIVVESKTDPRRGKLSTAIVS 359
            .|.....|..|:                       |..|....:...||...:|.. ||...:|
  Fly   326 FAKLYADTYEGVAYLDFAKRLWGDMYFNSKTRKFSKKQPHNSAQRSFVEFILEPMY-KLIAQVV- 388

  Fly   360 RGTLRKGSV---LLSGLAHAKVR--------------------------GLFD----HNGQPLSE 391
                  |.|   |...||...||                          |..|    |...||..
  Fly   389 ------GDVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLEN 447

  Fly   392 APPGTPVEILGWRELPLAGDLI-------LEVETEKK-----------AHAVLKYREHESQQEKI 438
            |.........|.:|..:..|:|       |.|.:.|.           ...::....|..|:.::
  Fly   448 AKRKVDHIYTGPKEGDIYRDMISCNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRV 512

  Fly   439 ESSSDEIRKKEEEH----------QAKYRAEREARRLAGRFRMRGGQRVKQVDENEGKPRVSVII 493
            ...:..::.:|:..          :::|:.|.. |..||.:.:     ::.:|:        .|:
  Fly   513 LGENYTLQDEEDSRILQVGRLWVFESRYKVELN-RVPAGNWVL-----IEGIDQ--------CIV 563

  Fly   494 KGDVHGSVEAILDVLETYNSNESCRLDIVHYGVGNVTEGDLELAKAFH---AIIYAFAVE----- 550
            |      ...|:|:                    ||.| ||.:.:...   ..|...|||
  Fly   564 K------TSTIVDI--------------------NVPE-DLYIFRPLKFNTQSIIKIAVEPVNPS 601

  Fly   551 --TPQLKAAKEVNIRSYNIIYRLIDDLKEQLSSKLPPVEVEEVLGEANVLQNFLINEGRK----- 608
              ...|...::|| :||.::...:::..|.:           :||...:..:.::::.||
  Fly   602 ELPKMLDGLRKVN-KSYPLLSTRVEESGEHV-----------ILGTGELYLDCVMHDLRKMYSEI 654

  Fly   609 -----EVPVAGC---------RCTKGVLKKAQKFRLLRDGEVVYDGPLESMRHLKNEVDTIKKDV 659
                 :..||.|         :|......|..|..::.:       |||     |...:.|:...
  Fly   655 DIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMISE-------PLE-----KGLAEDIENGT 707

  Fly   660 ECGLRFRDTKVLPQAGDILQCYTTKMEAQQTDWD 693
            .| :.:...::    |:..|.        ..|||
  Fly   708 VC-INWNKKRI----GEFFQV--------NYDWD 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	158..689	CDD:223606	127/692 (18%)
		IF2_eIF5B	163..327	CDD:206674	52/212 (25%)
		IF2_mtIF2_II	336..431	CDD:293903	26/145 (18%)
		IF-2	482..575	CDD:288813	18/102 (18%)
		mtIF2_IVc	593..680	CDD:293893	16/105 (15%)
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	16/88 (18%)
		PTZ00416	115..957	CDD:240409	134/718 (19%)
		Snu114p	132..340	CDD:206730	53/225 (24%)
		Translation_Factor_II_like	477..568	CDD:295476	14/110 (13%)
		snRNP_III	589..660	CDD:293921	14/82 (17%)
		EF2_IV_snRNP	660..837	CDD:238840	17/94 (18%)
		eEF2_C_snRNP	832..911	CDD:239765
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930