DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mIF2 and CG2017

DIOPT Version :9

Sequence 1:	NP_651621.2	Gene:	mIF2 / 43382	FlyBaseID:	FBgn0039588	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_649603.3	Gene:	CG2017 / 40733	FlyBaseID:	FBgn0037391	Length:	643	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	85/409 - (20%)
Similarity:	139/409 - (33%)	Gaps:	155/409 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 ADLKIIQEIAKKLGAKTRVVATPEETNADEQKERDVAPRPPAAPELLQPRPP-------VVTVMG 169
            |.|..::::|..|||.|.|:           :.:.:|.|...|..|::..|.       .|.|:|
  Fly   169 ASLTTLKQMAHSLGASTSVL-----------RRKTIAARRAVAEVLVRKIPDDQHNIEVRVAVLG 222

  Fly   170 HVDHGKTTL--------LDSLRGA----------DVAAGEAGGITQHIGAF-------------T 203
            ..|.||:||        ||:..|.          ::.:|....|:.....|             .
  Fly   223 GADAGKSTLLGVLTQDELDNGHGRARLNMFRHMHEIQSGRTSCISHETLGFDALGNVVNYKYNEM 287

  Fly   204 VTLE-----NGERVTFLDTPGHAAF--SAMRARGAVATDIIVLVVAAEDGVMAQTREVIQLAKEA 261
            :|.|     :.:.|||:|..||..:  :.::|....:....:|||:|..|....|.|.:.:.:..
  Fly   288 MTAEEISDRSSKLVTFMDLAGHRRYMRTTVQALSGYSPHYAMLVVSAGSGCNDTTEEHLAIVRAL 352

  Fly   262 QVPIIVALNKID--KPEANIEKSKRELAQMGL------------ALEEHGGDV--QVIPI---SA 307
            .:|..|.:.|.|  .|:|.:::....|..:|.            |:......:  .::||   |.
  Fly   353 DMPFFVLVTKTDITSPDATVQELCNLLTTIGCRKVPFVVTNTDEAISAGSNQISENIVPIFCVSN 417

  Fly   308 LKGTNLELLAE------------------------------AVSTQATLMGLKADPTG-LVEGIV 341
            :.||.|.|:.:                              .||....::|      | ||:|::
  Fly   418 VTGTGLNLVTKFLYVLSPGISNAEKDRLEQESCEFQVDEIFRVSDVGPVVG------GLLVQGVL 476

  Fly   342 VES---KTDP--------------RRGKLSTAIVSRG--------------TLRKGSVLLSGLAH 375
            .|:   |..|              .|.|....:|..|              |||.|.|||..:.:
  Fly   477 TENMAMKIGPLPDGSFHPVTVNTIHRNKAPCRVVRAGQSASLSFSMDQDVPTLRSGMVLLGDIGN 541

  Fly   376 ------------AKVRGLF 382
                        |||..||
  Fly   542 SLDEPYGTFFFQAKVSVLF 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	158..689	CDD:223606	73/363 (20%)
		IF2_eIF5B	163..327	CDD:206674	48/257 (19%)
		IF2_mtIF2_II	336..431	CDD:293903	22/90 (24%)
		IF-2	482..575	CDD:288813
		mtIF2_IVc	593..680	CDD:293893
CG2017	NP_649603.3	GTPBP1	100..635	CDD:227583	85/409 (21%)
		GTPBP1_like	217..436	CDD:206728	46/218 (21%)
		GTPBP_II	450..536	CDD:293895	19/91 (21%)
		GTPBP_III	547..634	CDD:294007	5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930