Protein Alignment mIF2 and Eif5b

DIOPT Version :10

• Sequence 1: NP_651621.2
• Gene: mIF2 / 43382
• FlyBaseID: FBgn0039588
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001103611.1
• Gene: Eif5b / 308306
• RGDID: 735017
• Length: 1216
• Species: Rattus norvegicus
• Alignment Length: 816
• Identity: 206/816 - (25%)
• Similarity: 321/816 - (39%)
• Gaps: 225/816 - (27%)

  Fly    41 KRRKT---AEEKKSPRIIEYS----------PKKFQT--------------AG-----GGASDIW 73
            |::||   .|.|::...:|.|          |:|.:|              ||     ..|||..
  Rat   449 KKKKTPQQLESKEALETVEVSAPVEVVDQGVPEKEETPPSVDAEEDEETEDAGLDDWEAMASDEE 513

  Fly    74 R-------HMTVAQLAKELERSLDDVQEAMLY-------VKGADNIEPAFKLADLKIIQEIAKKL 124
            |       |:.|.:..:|.|...:|..|....       .:|:|..|..:||:|.|   ::.|..
  Rat   514 REKEGNMIHIEVEENPEEEEEEEEDEDEEDSEDEEDEGDSEGSDGDEEDYKLSDEK---DLGKAG 575

  Fly   125 GAK-TRVVATPEETNAD-----EQKERDVAPRPPAAPEL--------LQPRPPVVTVMGHVDHGK 175
            ..| .:..::..|.::|     |::..|.|.|......|        .:.|.|::.|:||||.||
  Rat   576 DTKPNKDASSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHGKNVNTEKLRAPIICVLGHVDTGK 640

  Fly   176 TTLLDSLRGADVAAGEAGGITQHIGAFTVTLE----------NGER-------VTFLDTPGHAAF 223
            |.:||.||...|..||||||||.|||..|.||          |.:|       :..:|||||.:|
  Rat   641 TKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESF 705

  Fly   224 SAMRARGAVATDIIVLVVAAEDGVMAQTREVIQLAKEAQVPIIVALNKIDK-------PEANI-- 279
            |.:|.||:...||.:|||....|:..||.|.|.:.|..:.|.||||||||:       |::::
  Rat   706 SNLRNRGSSLCDIAILVVDIMHGLEPQTIESINILKSKKCPFIVALNKIDRLYDWKKSPDSDVAV 770

  Fly   280 --EKSKR---------------ELAQMGL--ALEEHGGD----VQVIPISALKGTNL-ELLAEAV 320
              :|.|:               |.||.||  ||.....|    |.::|.||..|..: .|:...|
  Rat   771 TLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLV 835

  Fly   321 STQATLMGLKADPTGLVEGIVVESKTDPRRGKLSTAIVSRGTLRKGSVLL----SGLAHAKVRGL 381
            ....|::..:......:...|:|.|..|..|.....|:..|.|::|..::    .|....::|||
  Rat   836 ELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGL 900

  Fly   382 FDHNGQPLSEAPPGTPVEILGWRELPLAGDLILEVETEKKAHAVLKYREHESQQEK--------I 438
            .         .||  |:     :||.:..    :.|..|:..|....:......||        :
  Rat   901 L---------LPP--PM-----KELRVKN----QYEKHKEVEAAQGVKILGKDLEKTLAGLPLLV 945

  Fly   439 ESSSDEIRKKEEE--HQAKYRAEREARRLAGRFRMRGGQRVKQVD-ENEGKPRVSVIIKGDVHGS 500
            ....|||...::|  |:.|                   |.:..:. |.:|     |.::....||
  Rat   946 AYKDDEIPVLKDELIHELK-------------------QTLNAIKLEEKG-----VYVQASTLGS 986

  Fly   501 VEAILDVLETYNSNESCRLDIVHYG--VGNVTEGDLELAKAF------HAIIYAFAV----ETPQ 553
            :||:|:.|:|        .::.:.|  :|.|.:.|:..|...      :|:|.||.|    :..:
  Rat   987 LEALLEFLKT--------SEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQE 1043

  Fly   554 LKAAKEVNIRSYNIIYRLID-------DLKEQLSSKLPPVEVEEVLGEANVLQNFLINEGRKEVP 611
            :..:..|.|.|..|||.|.|       |.|:|...:...:.|...  :..:|..::.|.  ::..
  Rat  1044 MADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPC--KMKILPQYIFNS--RDPI 1104

  Fly   612 VAGCRCTKGVLKKAQKFRLLRDGEVVYDGPLESMRHLKNEVDTIKKDVE-C-------------- 661
            |.|.....|.:|:.... .:.....|..|.:.|:.....:||..||..| |
  Rat  1105 VIGVTVEAGQVKQGTPM-CVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMF 1168

  Fly   662 GLRFRDT-----KVLPQAGDILQCYTTKMEAQQTDW 692
            |..|..|     |:..|:.|.|:.: .:.|.|::||
  Rat  1169 GRHFEATDILVSKISRQSIDALKDW-FRDEMQKSDW 1203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	159..688	CDD:440298	165/632 (26%)
Eif5b	NP_001103611.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..604		34/157 (22%)
		PRK04004	623..1198	CDD:457675	164/632 (26%)
		G1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	634..641		5/6 (83%)
		G2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	659..663		3/3 (100%)
		G3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	698..701		2/2 (100%)
		G4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	752..755		2/2 (100%)
		G5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	820..822		1/1 (100%)