DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mIF2 and mtif2

DIOPT Version :9

Sequence 1:	NP_651621.2	Gene:	mIF2 / 43382	FlyBaseID:	FBgn0039588	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_004914796.1	Gene:	mtif2 / 100496951	XenbaseID:	XB-GENE-1012578	Length:	745	Species:	Xenopus tropicalis

Alignment Length:	733	Identity:	336/733 - (45%)
Similarity:	469/733 - (63%)	Gaps:	51/733 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRIINISRLGNTLHFSRAVTQWQL----PLA----------FQREFHVSAA----RLKRRKTAE 47
            |:|:.|..|..:.|..:.|..:|:|    |||          :|.:..:|.|    |....|..:
Frog    27 MVRLHNTCRKLHALCHTNARIKWRLVQCPPLAVCVAHLCPPSWQTDTFISVALSQYRCLSSKEGK 91

  Fly    48 EKKSPRIIEYSPKKFQTAGGGASDIWRHMTVAQLAKELERSLDDVQEAMLYVK-GADNIEPAFKL 111
            ..|..::....||:.:.    ..:||.:|||..||:.:.:..:.|.||:|:.. ..:.:|....|
Frog    92 SFKKHKLSPIKPKQEKQ----EVEIWNNMTVGDLARAMNKDTEHVYEALLHTDLDLEALEEKSVL 152

  Fly   112 ADLKIIQEIAKKLGAKTRVVATPEETNADEQKERDVAPRPPAAPELLQPRPPVVTVMGHVDHGKT 176
            :: |.|:|..||.|.|.:.....||   ..::.:|...|.||.|.:|.|||||:|:|||||||||
Frog   153 SE-KWIKEAIKKSGMKFKYAKIKEE---KVRENKDAVKRVPADPAVLIPRPPVITIMGHVDHGKT 213

  Fly   177 TLLDSLRGADVAAGEAGGITQHIGAFTVTLENGERVTFLDTPGHAAFSAMRARGAVATDIIVLVV 241
            ||||.||...|||.||||||||||||.|.|.:|||:|||||||||||||:|.|||..|||::|||
Frog   214 TLLDQLRKTQVAAMEAGGITQHIGAFNVQLPSGERITFLDTPGHAAFSAIRERGANVTDIVILVV 278

  Fly   242 AAEDGVMAQTREVIQLAKEAQVPIIVALNKIDKPEANIEKSKRELAQMGLALEEHGGDVQVIPIS 306
            |||||||.||.|.||.||.|:||||:|:||.|||||:.||.|:||....:..||:||::|.|.||
Frog   279 AAEDGVMKQTVESIQHAKNAKVPIILAINKCDKPEASPEKVKKELLSHDIVCEEYGGEIQAIHIS 343

  Fly   307 ALKGTNLELLAEAVSTQATLMGLKADPTGLVEGIVVESKTDPRRGKLSTAIVSRGTLRKGSVLLS 371
            ||||.||:.|.||..|.|.::.|||||||||||.|||.:||..:|.::||||.||||:||:||::
Frog   344 ALKGHNLQALTEATVTLAEMLELKADPTGLVEGTVVECRTDKGKGPVTTAIVQRGTLKKGAVLVA 408

  Fly   372 GLAHAKVRGLFDHNGQPLSEAPPGTPVEILGWRELPLAGDLILEVETEKKAHAVLKYREHESQQE 436
            |...||||.:||.|.:.||:|.|.|||||:||::||.|||.|||||||::|..|:.:|::..:||
Frog   409 GKTWAKVRLMFDENNKALSQAGPSTPVEIVGWKDLPSAGDEILEVETEQRAREVVDWRKYVEEQE 473

  Fly   437 KIESSSDEIRKKEEEHQAKYRAEREA-------RRLAGRFR-------MRGGQRVKQVDENEGKP 487
            ||....:.|..|::||:..|:...|.       :|.:..::       .|.|::    .|:| .|
Frog   474 KIIGDMEVIEAKQKEHRDAYKKNLETFSNLNWRQRKSAMYKANKQLMATRPGEK----SESE-TP 533

  Fly   488 RVSVIIKGDVHGSVEAILDVLETYNSNESCRLDIVHYGVGNVTEGDLELAKAFHAIIYAFAVET- 551
            ...:||||||.|||||||.:::||::.:.|.||:||:|||:::|.|:.||:.|...:|.|.|.:
Frog   534 MFPLIIKGDVDGSVEAILSIIDTYDAEDQCELDLVHFGVGDISENDIALAETFKGYVYGFNVNSN 598

  Fly   552 ---PQLKAAKEVNIRSYNIIYRLIDDLKEQLSSKLPPVEVEEVLGEANVLQNFLINEGRKEVPVA 613
               .||.|.|||.::.:.:||.|::||:|:||.:||||..|.:.|||:||..|.:..|:|:|.||
Frog   599 KAVQQLAAKKEVTVKLHKVIYHLVEDLREELSKQLPPVIEENIKGEASVLATFDVTVGKKKVQVA 663

  Fly   614 GCRCTKGVLKKAQKFRLLRDGEVVYDGPLESMRHLKNEVDTIKKDVECGLRFRDTKVLPQAGDIL 678
            |||..||:|.|..|.:::|:.:::::|.|.|::|||::|.|:|..|||||.. |..:..:.||.:
Frog   664 GCRVQKGILDKKVKCKVIRNRKMIWEGYLTSLKHLKDDVQTVKTGVECGLSL-DKDIDVKIGDEV 727

  Fly   679 QCYTTKMEAQQTDWDPGF 696
            .|...|...|:..|||||
Frog   728 LCVEEKEVQQKISWDPGF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mIF2	NP_651621.2	InfB	158..689	CDD:223606	284/548 (52%)
		IF2_eIF5B	163..327	CDD:206674	112/163 (69%)
		IF2_mtIF2_II	336..431	CDD:293903	56/94 (60%)
		IF-2	482..575	CDD:288813	43/96 (45%)
		mtIF2_IVc	593..680	CDD:293893	37/86 (43%)
mtif2	XP_004914796.1	InfB	195..739	CDD:223606	285/549 (52%)
		IF2_eIF5B	200..364	CDD:206674	112/163 (69%)
		IF2_mtIF2_II	373..467	CDD:293903	55/93 (59%)
		IF-2	526..625	CDD:288813	43/103 (42%)
		mtIF2_IVc	643..729	CDD:293893	37/86 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2712
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1840
Inparanoid	1	1.050	591	1.000	Inparanoid score	I975
OMA	1	1.010	-	-		QHG56520
OrthoDB	1	1.010	-	-		D1124591at2759
OrthoFinder	1	1.000	-	-		FOG0004112
OrthoInspector	1	1.000	-	-		oto103190
Panther	1	1.100	-	-	LDO	PTHR43381
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2379
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080