DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc98D and DNAH11

DIOPT Version :9

Sequence 1:	NP_524541.3	Gene:	Dhc98D / 43379	FlyBaseID:	FBgn0013813	Length:	5080	Species:	Drosophila melanogaster
Sequence 2:	NP_001264044.1	Gene:	DNAH11 / 8701	HGNCID:	2942	Length:	4516	Species:	Homo sapiens

Alignment Length:	4954	Identity:	1403/4954 - (28%)
Similarity:	2348/4954 - (47%)	Gaps:	681/4954 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 ISSEAKESGPGLLELSKPSEFRLRALKQQKKMKEKEAAAKKAKAKKTDAEP-------------T 395
            ::|.|.....|.:||.:..|            .|:||||::|::...||..             |
Human    21 LTSGAGLEAVGAVELEEEEE------------NEEEAAARRARSFAQDARVRFLGGRLAMMLGFT 73

  Fly   396 EEE-----EEADAHKV-------------------EAHLSSSEEEVEIKVEKLTIGQRWEKMLNE 436
            ||:     |..|..:|                   ...|::|:|.......||..   ..|.:.|
Human    74 EEKWSQYLESEDNRQVLGEFLESTSPACLVFSFAASGRLAASQEIPRDANHKLVF---ISKKITE 135

  Fly   437 TKAKVEAEHAAEEATPPRITPIQRRLLKEIEEFQSEITWTI-----NHIVWA------------F 484
            :....:..........|.::      |..:..|..||...:     ||..|:            .
Human   136 SIGVNDFSQVVLFGELPALS------LGHVSAFLDEILVPVLSNKNNHKSWSCFTSQDMEYHIEV 194

  Fly   485 SLPSSYILPGQEATEFEDAIIRVPVDPKRLDLVITYTQQQ-----------LEEVVDGWIKYLKK 538
            .....||..|:.:..   .::.:|....::||....::.:           :|.||..|...:::
Human   195 MKKKMYIFRGKMSRR---TLLPIPTVAGKMDLDQNCSENKPPSNERIILHAIESVVIEWSHQIQE 256

  Fly   539 TMKTLTDAKLDD---FTPMAEHRYWHKMEVELYGTLEQLKTEFVVAVLQRLTDDKSPVLDEWQAV 600
            .::..:..:|.:   .:|.||..:|......|....:||:...|:.:::.||..:|......:.:
Human   257 IIERDSVQRLLNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLKDI 321

  Fly   601 VEKTEARFKLAKENSDYLGTIIDYLEKVRSYESFKMVVLQIPNIMVGLRH----IWTMSSHYCRD 661
            ....|.....|::...||..:..:::.::..|..:..:|..|     |.|    ||:.|..|...
Human   322 FLAVENALLEAQDVELYLRPLRRHIQCLQETEFPQTRILIAP-----LFHTICLIWSHSKFYNTP 381

  Fly   662 PEMQVLLCQISNVFVQKVKSIINFENIFKYSATYTYETATNCANLLRCWKQAYKLSRQHIEDSGA 726
            ..:.|||.:..|:|:.:..:.::.|::.:.....:.|......|:|:.:|.::...|:.:.....
Human   382 ARVIVLLQEFCNLFINQATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFM 446

  Fly   727 GSR---WEFDRVALFNEVNHIHRVAVDIAYVGRVFVQYENLFGHRLKACIADPSIVDNLMRKVYR 788
            |.:   |:|....:|...:......:.|..:....:::|.|  .||:......:|::..:.::..
Human   447 GRKLRPWDFQSHLVFCRFDKFLDRLIKIEDIFATTLEFEKL--ERLEFGGTKGAILNGQVHEMSE 509

  Fly   789 MLDDLIKSVDYDMFRPGNWENWEY----------SLELFNKRLDNVENEAKNVIDQSINSLLSSE 843
            .|.:|.|......:.|.:..|.|:          :|| |::||..:..||    ..:.|.|.::.
Human   510 ELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLE-FDRRLGTIICEA----FFNCNGLEAAF 569

  Fly   844 KGLDLVVNAMNIDTRATLQEFVATKHENLLRFFVTEINAVERVFTKLKKS-----PPMAKHQPAK 903
            |.|.:..|.:.   :..:.|..:..:..|:..|.||::..::::.:..|.     ..:.|:.|..
Human   570 KLLTIFGNFLE---KPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQIECGHVVLNKNMPFT 631

  Fly   904 ISAIFWARLLGKKLKTSVLAFKRVEDEPAIKNSFLKRSS----FKQYFELMTVMFQFEKVLFENF 964
            ...:.||:.:.::|:.....|      .:::..||....    :::|.|:.|::.|||..::..:
Human   632 SGNMKWAQQVLQRLQMFWSNF------ASLRYLFLGNPDHALVYQKYVEMTTLLDQFESRIYNEW 690

  Fly   965 IQNATYLVNTTNRSNVLRIRICKESTMSYISEAVQTLKAKPRPELQMTSDRRVTPVKSSNL-MPV 1028
                        :|||  ..||:                                   .|| .|:
Human   691 ------------KSNV--DEICE-----------------------------------FNLNQPL 706

  Fly  1029 QSEAFSAYSVADSAGTEISSESENEGLLVGDTSQKKLMCRINRLTVLVAMIMWMVSNTRKANIQL 1093
            ..  |||.:                |||
Human   707 VK--FSAIN----------------GLL------------------------------------- 716

  Fly  1094 QECTAFIKMVKDKKPKDVTAMDRHCVRTCELLQRAESQYLLPIWRELVGEKTLIEYDMDFVVNLK 1158
              |..|       .||.|..:             .|.:|||.:.::.:.:..|       .:..|
Human   717 --CVNF-------DPKLVAVL-------------REVKYLLMLKKQDIPDSAL-------AIFKK 752

  Fly  1159 RDVFDVLFEAQQFEHLGFTLPAVLRTAIMKKDLLFKDYERMTE---------VVDRYRSIINNLS 1214
            |:..        .:::|            ..|||.:.|.::.:         :.|..|:|...|:
Human   753 RNTI--------LKYIG------------NLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797

  Fly  1215 MSEVIFLRGHIYDTELFIQMGVGRYTWTSFNIGKFCDQINSQLRKLTSIVSQINFIRLDLRSRID 1279
            .:.                      ||.::.  ..|.....::|..||          :|..|::
Human   798 AAT----------------------TWLTWQ--DDCWGYIERVRAATS----------ELEHRVE 828

  Fly  1280 MIKSFNLFNLDDELKV-EDTSRSSGESYLQDRKNPSQRFKSVTGETITMFSVEKDVPADEKAEQA 1343
            ..:.        .:|| :.|.|......|..|:...:.......:...:|:        :|.:..
Human   829 RTQK--------NVKVIQQTMRGWARCVLPPRREHRREAAFTLEDKGDLFT--------KKYKLI 877

  Fly  1344 CGSGIYPCQGYFELLEASRNRKAAQMKKLYDSLGPVLVKLESLVLGTFSGRSDRMKTYYEYWEGE 1408
            .|.|   |: ...|:|.:|        ||:.: .|.|               |..|.|.|:.:
Human   878 QGDG---CK-IHNLVEENR--------KLFKA-NPSL---------------DTWKIYVEFID-- 912

  Fly  1409 TFKCIVDMTYQNLKCYINRLLSN-------KPMFEVNAVLLMSEIVLEPSVQELQNTIVTATKDY 1466
              ..:|:..:|.:...::..|.|       .|.|:...:||..|||.:||   |.........|.
Human   913 --DIVVEGFFQAIMHDLDFFLKNTEKQLKPAPFFQAQMILLPPEIVFKPS---LDREAGDGFYDL 972

  Fly  1467 ISRLRIFTRWMTGTCIACPLVEMGKQFKYNYT------YYEDVIQIRSIVDLVINIHDLASRVAN 1525
            :..:            .|....|..|.....|      |..|:..:..:.::...|.:....|.|
Human   973 VEEM------------LCNSFRMSAQMNRIATHLEIKNYQNDMDNMLGLAEVRQEIMNRVVNVIN 1025

  Fly  1526 EARGFVSQFRKYFNLWAFEKSFICQKFL--------------------EKQVTLIEIDEKFTFYS 1570
            :...|.:....:..||..:::...:.||                    |:..||.:..|:...|.
Human  1026 KVLDFRNTLETHTYLWVDDRAEFMKHFLLYGHAVSSDEMDAHANEEIPEQPPTLEQFKEQIDIYE 1090

  Fly  1571 SIVETLANTRKFQDIKC----VRINLEPLLASITQHAQDWCTTLGEELLRHVNDNMRAMRNEVKT 1631
            ::...::   ||:|.:.    .:::::|...|:....:.|.....|.|||.|.|::..::..:|.
Human  1091 ALYVQMS---KFEDFRVFDSWFKVDMKPFKVSLLTIIKKWSWMFQEHLLRFVIDSLNELQEFIKE 1152

  Fly  1632 LSLNLNKTTRELEDFKLV--MTTIGTVQSSTLTNEQKIHEMQETFTILSEHKIMFPYEDMLMAHH 1694
            ....|.:...|.:...||  |..:..|:|.....::....::||.|:|..:....|.:..:....
Human  1153 TDSGLQRELNEGDHDGLVDIMVHLLAVRSRQRATDELFEPLKETITLLESYGQKMPEQVYIQLEE 1217

  Fly  1695 LEKRWKRL-FLSALYRYEKLQPIKQKFADMTSVEIDEFCDDLAEFIKDYDENGPGSVGAELERGV 1758
            |.:||:.. .::|..|:| :.|:......:...:...|....|||.:.:....|  :|...|...
Human  1218 LPERWETTKKIAATVRHE-VSPLHNAEVTLIRKKCILFDAKQAEFRERFRHYAP--LGFNAENPY 1279

  Fly  1759 RLMDPYGQKIAERESRREELANAERLFDMAMVDYHEFARVQTEFEGLQQLYKLYKAQKYAREGWG 1823
            ..:|...:::...|....::..:.|||::|:.:|.:..:.:.|.:.|:.|:.:....:.:.:.|.
Human  1280 TALDKANEELEALEEEMLQMQESTRLFEVALPEYKQMKQCRKEIKLLKGLWDVIIYVRRSIDNWT 1344

  Fly  1824 KTLWADLDPNVLTEGVESYLKEFRKFTKAVRTLPVGVQLEIHMKQFKGTVPLMVSLKHEALRERH 1888
            ||.|..:....:...:..:.||.....|.||.......||..:|....::..:..|:..|||:||
Human  1345 KTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLRAITELQSPALRDRH 1409

  Fly  1889 WLQLMEKTGQYFDMSPARFTLENMFAMQLHKYQEIAEQILTNAIKELQIERGVQAVIETWASMAF 1953
            |.|||:..|..|.::.|. ||.::.|::||:.::...:|:..|:|||..|:.:..:.:|||:|.|
Human  1410 WHQLMKAIGVKFLINEAT-TLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKF 1473

  Fly  1954 KTFKHFKGSDDRGWVLGPVDE-IMQILEDNAMNLQSMGASQFIGPFLETVNKWERTLALISEIID 2017
            ....|::    .|..|...|| :.:.||.|.:.||::..|:::..|:|.|..|:..|.:...:|.
Human  1474 SYEVHYR----TGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIF 1534

  Fly  2018 EWLVVQRKWLYLEGIFI-GGDIRTQLPEEARKFDDIDKSYRRIMVDCAKNPLVVPFCTVPGRLVE 2081
            .|:.|||.|.:||.||: ..|||.||.::||:||.:|..::.:|...||...|:.....|....:
Human  1535 TWMEVQRTWSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEK 1599

  Fly  2082 IQGLGIGLENCQKSLNEYLDSKRRIFPRFYFISTDELLSILG-SSEPSAVQNHIIKMYDNIKSLR 2145
            ::.|...|..|:|:|.|||::||..||||||:|:.:||.||. .::|..|..|:.|::|:|..|:
Human  1600 LKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSADLLDILSKGAQPKQVTCHLAKLFDSIADLQ 1664

  Fly  2146 LVKEGSQTI----VTGMISSEGEVMEFRHSARAAGRVEYWMNDVLDEMRRSNRFINKTAIYDFGT 2206
            .  |.:|.:    ..||.|.|.|.:.|:......|.||.|:..:...|:.:.|.....||..:.
Human  1665 F--EDNQDVSAHRAVGMYSKEKEYVPFQAECECVGHVETWLLQLEQTMQETVRHSITEAIVAYE- 1726

  Fly  2207 DLQISRPDWLMNYQGMVGLAASQVWWTAEVEEAFDQAQNHGNMRAMKDFLGKNNYQIEELVLKVR 2271
              :..|..|:.::...|.|.:||:|||.:|..||.:.: .|...|:|||..|...|:..|:..:.
Human  1727 --EKPRELWIFDFPAQVALTSSQIWWTTDVGIAFSRLE-EGYETALKDFHKKQISQLNTLITLLL 1788

  Fly  2272 SNLSRNDRLKFKAQCTVDVHARDIIDNFVRDNVLDASEFSWESQLRFYWIKFYDNLHVLQCSGSF 2336
            ..|...||.|....||:||||||::...:...|:....|:|.||||..|.....:..|..|...|
Human  1789 GELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSQLRHRWEDTQKHCFVNICDAQF 1853

  Fly  2337 DFGYEYMGLNGRLVITPLTDRIYLTITQALLMNLGGAPAGPAGTGKTETVKDLAKAMGLLCVVTN 2401
            .:.|||:|.:.||||||||||.|:|:||:|.:.:.||||||||||||||.|||.:|:|::..|.|
Human  1854 QYFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFN 1918

  Fly  2402 CGEGMDYRAVGTILSGLVQCGAWGCFDEFNRIDISVLSVISTQLQTIRNGLIRKLDRFVFEGVEI 2466
            |.|.|||:::|.|..||||.||||||||||||.:.||||::.|::.|.:.:..:..||||.|..|
Human  1919 CSEQMDYKSIGNIYKGLVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAI 1983

  Fly  2467 HLDPKCGVFVTMNPGYAGRTELPESVKALFRPVTCIKPDLELICLISLFSDGFLTAKVLAKKMTV 2531
            .|.|..|:|:||||||||||||||::||||||...:.||:||||.|.|.::||:.|:.||:|...
Human  1984 TLKPSVGIFITMNPGYAGRTELPENLKALFRPCAMVAPDIELICEILLVAEGFVDARALARKFIT 2048

  Fly  2532 LYSLAQAQLSKQCHYDWGLRSLNSVLRMAGVMKRQSEDLPEAVVLMRVLRDMNFPKFVFEDVPLF 2596
            ||:|.:..||||.|||||||::.|||.:||.:||..::.||..||||.|||.|.||.|.:|:|:|
Human  2049 LYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMRALRDFNMPKIVTDDIPVF 2113

  Fly  2597 LGLIKDLFPGIDCPRIGYPDFNAAVRHVLV------NDGYILLPDQEDKVVQMYETMMTRHSTML 2655
            |||:.||||.:|.||.....|...||...:      .:.:||      ||||:.|.:..|||..:
Human  2114 LGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFIL------KVVQLEELLAVRHSVFV 2172

  Fly  2656 VGPTGGGKTVVINALVKAQTHMGLPTKCLVLNPKACSVIELYGFLDMETRDWID---------GL 2711
            ||..|.||:.::..|.:...:|........|||||.:..||:||:...||:|.|         ||
Human  2173 VGNAGTGKSKILRTLNRTYVNMKQKPVWNDLNPKAVTTDELFGFIHHATREWKDGKIVYSYFIGL 2237

  Fly  2712 FSNIFREMNKPIEREERRYACFDGDVDALWIENMNSVMDDNKLLTLANGERIRLENYCALLFEVG 2776
            ||:|.||... ::.:..::...|||:|.:|||::|:||||||:||||:.|||.|..:..||||:.
Human  2238 FSSILREQAN-LKHDGPKWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIALTPFMRLLFEIH 2301

  Fly  2777 NLNYASPATVSRAGMVYVDPKNLRYSPFWQRWV-LTRPEPQRELLNDFFEKIITQSIAFILEGLD 2840
            :|..|:||||||||::||:|::|.::|:...|: ..|.:.::..|...|:|.:...:..:
Human  2302 HLRSATPATVSRAGILYVNPQDLGWNPYVASWIDRRRHQSEKANLTILFDKYVPACLDKL----- 2361

  Fly  2841 GTTQGNPLKLVIMQTDLNMVTQFCNLYDALLPNYVMDSKNYDEPVQQNYNTDS----LECCFLQA 2901
                ....|.:....:.::|...|.|.:.||             ..:|..:||    .|..|:.|
Human  2362 ----RTSFKTITSIPESSLVQTLCVLLECLL-------------TPENVPSDSPKEVYEVYFVFA 2409

  Fly  2902 VYGSMGACL----VEKHQPVFDEY----MKRISGFPLVQDTPENPASGGQFPQSKPTLYDYFWDV 2958
            ...:.|..|    :..:|..|..:    ||.:                 :|| |:.|::||:.|.
Human  2410 CIWAFGGTLLQDQISDYQADFSRWWQKEMKAV-----------------KFP-SQGTIFDYYVDH 2456

  Fly  2959 KDNVWKAWEWVVQPYTHDPQVKFSEILVPTVDNTRTNRTLSLMSEIKRPVLLVGEAGTSKTATIM 3023
            |......|...:..:|.||.|....:||.|.:..|....:.|:.|..:|::|||.||..||..:.
Human  2457 KTKKLLPWADKIAQFTMDPDVPLQTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVG 2521

  Fly  3024 QYLRNLNPSVNVILNINFSSRTSSLDVQHTLEAAVEKRTKDTYGPPMGKRIACFIDDMNMPQVDD 3088
            ..|.:|:... ::..:.|:..|:|..:|..||..:||:....|||...|::..||||||||:||.
Human  2522 DTLASLSEDY-IVSRVPFNYYTTSTALQKILEKPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDL 2585

  Fly  3089 YGTQQPIALLKLFFERGGMYDRDKDLNWKKFKDLTFYAAMGTAGGGRNEVDPRFISMFSTYNIIF 3153
            |||.||..|::...:.|..|||.| :..|:..:..:.|.|....|... ::||....|:.:...|
Human  2586 YGTVQPHTLIRQHIDYGHWYDRQK-VMLKEIHNCQYVACMNPMVGSFT-INPRLQRHFTVFAFNF 2648

  Fly  3154 PNDESLIQIYSSIFKGHMVFVKFQPEYMLIADMIVHMTLKLFKMVIVDLPPTPSKFHYIFNLKDL 3218
            |:.::|..||..||..|.....|.|..:.....::..|:...:.::.:..||..||||||||:||
Human  2649 PSLDALNTIYGQIFSFHFQQQAFAPSILRSGPTLIQATIAFHQTMMCNFLPTAIKFHYIFNLRDL 2713

  Fly  3219 SRIFAGMLLIEPTCFKGLRDLIRVWRNEYTRIICDRLITDNDIANVRRNLAVEVAERFPPTFEEE 3283
            |.:|.|:|...|.|.||..|||.:|.:|..|:..|:||...|....:|.: :|.|.::   ||
Human  2714 SNVFQGILFASPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQRRM-LETAYKY---FE-- 2772

  Fly  3284 HGFIDAAAAEAEAQARLLYEPSKADIDGGEEEGEEEEEGEEAPQVILSLKDYVLRDPLLFGDFRN 3348
                                    .||                      ...:|:.||:   :.:
Human  2773 ------------------------GID----------------------SHMLLQQPLI---YCH 2788

  Fly  3349 FTNESEPRLYEDLLDYNSVYFLFTEILEEYCERKQKMTLVLFEDCLEHLTRVHRTLRMNRGHVLL 3413
            |.:..:...|..:.|:..:..:.||.|:.|.|....|.||||||.::|:.|:.|.||..:|..||
Human  2789 FADRGKDPHYMPVKDWEVLKTILTETLDNYNELNAAMHLVLFEDAMQHVCRISRILRTPQGCALL 2853

  Fly  3414 IGVGGSGKKCITRLAAFAAECDVFEITISRGYNEAAFREDLKVLYTIAGVKRKKVVFLFTGAQVA 3478
            :|||||||:.::||||:....:||:||::.||.....|.||..||...|.|....|||.|.|||.
Human  2854 VGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVL 2918

  Fly  3479 EEGFLELINNILTVGQVPALFPDEDKDGIVNQVRKFAEEDGVSASKDAVWGYFLRTCAENLHVVL 3543
            :|.||.|||::|..|::|.||.|||.|.|::.:.......|:..|::..|.:|:......|.::|
Human  2919 DESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIIL 2983

  Fly  3544 CMSPAGDALRNRCRNFPGLIGSTYIDWVFPWPRQALYAVAKLFLTEHRLIPASHREAIVEHVVHV 3608
            |.||.|..||.|.|.||.::..|.|||...||::||.:|::.|:.|.:.|...|:::|...:.||
Human  2984 CFSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDSISLFMAHV 3048

  Fly  3609 HTSIQQYSKDYLAKLRRNNFVTPKHYLDYINTYRGLLEEKAKFITQQRSRLGEGIKKIEEASVQI 3673
            ||::.:.|..|....||:|:.|||.:|:.|:.::.||::|...:::::.||..||:|::..:.|:
Human  3049 HTTVNEMSTRYYQNERRHNYTTPKSFLEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQV 3113

  Fly  3674 DELRIIVTEQKKNVAVASEECEAMLVTIESSTQKANVKK--AEASEK---SVEVEIKGKQIAIEK 3733
            .:|:..:..|:..:.:.:.:.||::..|...|:|.:.:|  |:|.|:   :::.|:..||...|.
Human  3114 GDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQRECEA 3178

  Fly  3734 DEAEEILAEAMPALEEARLALSQLEKAQITEIRSFATPPAAVQVVCECVAIL---KGY--KEINW 3793
            |     |.:|.|||..|..||:.|.:..::|:::|..||.||..|...|.:|   :|.  |:.:|
Human  3179 D-----LLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSW 3238

  Fly  3794 KSAKGMMSDV-NFLKSLMEMDCEALTQKQITQCRQHMKTGNLED-------MAKISVAGAGLLRF 3850
            |:||..|..| :||::|:..|.|.:.:..:....:|.    |:|       :...|.|.|||..:
Human  3239 KAAKVFMGKVDDFLQALINYDKEHIPENCLKVVNEHY----LKDPEFNPNLIRTKSFAAAGLCAW 3299

  Fly  3851 VRAVLGFFDVYKEVKPKKERLDFLVEEQEVQIKLLNHLNGEIQKLEEKLNELNENYATSMKQMRA 3915
            |..::.|::||.:|:||::.|.....|.....:.|..:..::..|:..|:.|..::..:..:...
Human  3300 VINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVR 3364

  Fly  3916 LTEMMQQAERRLIASDKLISGLTSELIRWSKEMASLGQQLIDSVGGCLISASFLAYTGAFTWEFR 3980
            ..|.:.|..:.:..:::|:..|.::.|||.:.:.|...|.....|..|::|:|::|.|.||.::|
Human  3365 CQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYR 3429

  Fly  3981 KAMVFDDWLEDI-ASLGIPIQLPFKIDGYLTTDVEISQWSNEGLPPDELSIQNGILTMRASRFPL 4044
            :.:|...|:..: ..:.||:.....:...||.|..|:.|:|||||.|.:|.:|..:.....|:||
Human  3430 QELVHCKWVPFLQQKVSIPLTEGLDLISMLTDDATIAAWNNEGLPSDRMSTENAAILTHCERWPL 3494

  Fly  4045 CIDPQLQALQWIRKREFKNNLKVLSFSDSDFLKQLEMAIMYGTPVLFEDVDDYIDPVIDDILQKN 4109
            .||||.|.::|| |.::..:|||.......||..:|.|:.:|..:|.|::::.||||:|.:|.:|
Human  3495 VIDPQQQGIKWI-KNKYGMDLKVTHLGQKGFLNAIETALAFGDVILIENLEETIDPVLDPLLGRN 3558

  Fly  4110 IRIQGGRKFVMLGDKEVDWDPSFRVYLTTKFSNPKFDPAVYAKALVINYTVTQTGLEDQLLSVVV 4174
            ...:|  |::.:||||.:::.:||:.|.||.:||.:.|.:.|:..::|:|||:.|||.|||:.||
Human  3559 TIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVV 3621

  Fly  4175 GTERPDLEAQRESLIAQTSENKQLLQQLEDSLLRELSTSTGNMLDNVELIETLENTKTKAGVVME 4239
            ..||||||..:..|....::.|..|:.|||.||..||.:.|:.||:.:|:|.||.|||....:..
Human  3622 SIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEH 3686

  Fly  4240 QLKLAADTAADIEVLRNGYRPAAKRGAVLFFALSDMATVNSMYQYALAAYLDVFVYSLRKAVPDA 4304
            ::..|.:....|...|..|||.|.|.::|:|.::|:..:|.:||::|.|:..:|..::.:|....
Human  3687 KVIEAKENERKINEARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRAIEQADKVE 3751

  Fly  4305 SLNKRLNNIIKTLTENVYCYGCTGIFERHKLLFSFQIATKLAQRDGILLQSELDFFIKGSIALTK 4369
            .:..|::.:::::|..|:.|....:||:.||.|..|:|.::..|...:...||||.::.::..|
Human  3752 DMQGRISILMESITHAVFLYTSQALFEKDKLTFLSQMAFQILLRKKEIDPLELDFLLRFTVEHT- 3815

  Fly  4370 SERSNPCKWLSEKSWEDVLKLAF--DF----PDIFGTLPDHFGRYLTEWKEWFDLENPEEVPCPG 4428
              ..:|..:|:.:||..:..:|.  :|    .|:.|:        ..:|::|.:.|.||:...|.
Human  3816 --HLSPVDFLTSQSWSAIKAIAVMEEFRGIDRDVEGS--------AKQWRKWVESECPEKEKLPQ 3870

  Fly  4429 DYNIKCNAFQKLMFLRCFRVDRIFRSINQYIVETMDEFYIMPPVVSFSAIYEQTSSTIPVCFVLS 4493
            ::. |.:..|||:.||..|.||:..::..::.|.:...|:....:.....:|::|...|:.|:||
Human  3871 EWK-KKSLIQKLILLRAMRPDRMTYALRNFVEEKLGAKYVERTRLDLVKAFEESSPATPIFFILS 3934

  Fly  4494 AGSDPTNDLIKLADTI---VGMSNFCHISLGQGQEKAALRLLDGAIKQGMWLMLQNGHLLIRFVR 4555
            .|.|...||..|...:   :....|.::|||||||..|...|:.|.|.|.|::|||.||:.:::.
Human  3935 PGVDALKDLEILGKRLGFTIDSGKFHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLG 3999

  Fly  4556 ELEKHLDRI-ENPHPDFRLWITTDPTPT-----FPIGILQKSLKVVTEPPNGLKLNLRSTYFKVR 4614
            .|||.|:|. :..|.|:|::::.:..||     .|.|:|:.|:|:..|||.|:..||.:..:...
Human  4000 TLEKLLERFSQGSHRDYRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTGMLANLHAALYNFD 4064

  Fly  4615 QERLESCS-HVAFRPLVYVLAFFHAVVQERRKYDKLGWNIAYDFNDTDFDVCTEILRTYLTRCGT 4678
            |:.||.|| ...|:.:::.|.:|||.|..|.::...||:.:|.||..|..:|..:|..||.  ..
Human  4065 QDTLEICSKEQEFKSILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLE--AN 4127

  Fly  4679 GKIPWNSLKYLIGEVMYGGRVIDDFDRRITNCYMNEYMGDFLFDEFKVF--HFYEDDNVDYCLPE 4741
            .|:||..|:||.||:||||.:.||:||::...|:.|:|...|.::..:.  .|.....:||.
Human  4128 SKVPWEDLRYLFGEIMYGGHITDDWDRKLCRVYLEEFMNPSLTEDELMLAPGFAAPPYLDYA--- 4189

  Fly  4742 EETILKEDYIAHIDKLPLVNKPDVFGLHPNAEIGYYTMAARNIWNSLIELQPQ---TGEGTGGIS 4803
                   .|..:|:::.....|.::||||||||.:.|:.:..::.:|:|:||:   :|:..|. |
Human  4190 -------GYHQYIEEMLPPESPALYGLHPNAEIEFLTVTSNTLFRTLLEMQPRNALSGDELGQ-S 4246

  Fly  4804 RDDFIDSVAAGILKKLPPAFETWRIRKQIQMSLSPTGVVLLQELDRFNLLVVRIKKTLELLRKAI 4868
            .::.:.:|...||:|||..|....| .|...:.||..:|..||.:|.|:|:..|:.:||.|..::
Human  4247 TEEKVKNVLDDILEKLPEEFNMAEI-MQKNSNRSPYVLVCFQECERMNILIREIRISLEQLDLSL 4310

  Fly  4869 AGEIGMDNVLDNIANSLFNGLLPAAWSKLAPATCKQLASWLEHLRLRAVQYKYWTLS-GEPLVMW 4932
            .||:.:...::....:|....:|..|||||..:...||.|...|.||..:...||.. ..|.|:|
Human  4311 KGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVW 4375

  Fly  4933 LSGLHIPQSYLTALVQIACRRNAWPLDRSTLFTYVTKFADPDDVEERPVTGCLVHGLYIEGGRFD 4997
            |||...|||:|||::|...|:|.||||::.|...||| ...:|....|..|..:|||::||.|:|
Human  4376 LSGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTK-KTKEDYGHPPREGAYLHGLFMEGARWD 4439

  Fly  4998 LATNQLARSHPKVLVEELAILAVEPIEAHRLKLQNTYLAPVYTTSLRRNAMGVGLVFEANLATSE 5062
            .....:..:..|.|...:.::..:.....|.:.:.||..|||.|.||    |...::...|.:.|
Human  4440 TQAGTIVEARLKELACPMPVIFAKATPVDRQETKQTYECPVYRTKLR----GPSYIWTFRLKSEE 4500

  Fly  5063 DLSHWILQGVCLTL 5076
            ..:.|:|.||.|.|
Human  4501 KTAKWVLAGVALLL 4514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc98D	NP_524541.3	DHC_N1	523..983	CDD:285571	91/499 (18%)
		DHC_N2	1798..2201	CDD:285579	127/409 (31%)
		P-loop_NTPase	2338..2565	CDD:304359	132/226 (58%)
		P-loop_NTPase	2654..2788	CDD:304359	59/142 (42%)
		P-loop_NTPase	2976..3246	CDD:304359	94/269 (35%)
		P-loop_NTPase	3378..3645	CDD:304359	108/266 (41%)
		MT	3658..3989	CDD:289543	93/348 (27%)
		AAA_9	4017..4233	CDD:289547	89/215 (41%)
		Dynein_heavy	4374..5068	CDD:281078	225/715 (31%)
DNAH11	NP_001264044.1	Stem. /evidence=ECO:0000250	1..1854		445/2144 (21%)
		DHC_N1	239..812	CDD:285571	126/770 (16%)
		DHC_N2	1319..1722	CDD:285579	127/409 (31%)
		P-loop_NTPase	1855..2084	CDD:304359	134/228 (59%)
		AAA 1. /evidence=ECO:0000250	1855..2076		130/220 (59%)
		AAA 2. /evidence=ECO:0000250	2136..2366		85/245 (35%)
		P-loop_NTPase	2169..2313	CDD:304359	60/144 (42%)
		P-loop_NTPase	2471..2741	CDD:304359	95/272 (35%)
		AAA 3. /evidence=ECO:0000250	2472..2719		85/249 (34%)
		AAA 4. /evidence=ECO:0000250	2817..3066		101/248 (41%)
		P-loop_NTPase	2818..3085	CDD:304359	108/266 (41%)
		Stalk. /evidence=ECO:0000250	3072..3403		88/339 (26%)
		MT	3097..3441	CDD:289543	94/352 (27%)
		AAA 5. /evidence=ECO:0000250	3459..3686		94/229 (41%)
		AAA_9	3468..3680	CDD:289547	89/214 (42%)
		Dynein_heavy	3820..4506	CDD:281078	224/713 (31%)
		AAA 6. /evidence=ECO:0000250	3896..4122		73/225 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1492at2759
OrthoFinder	1	1.000	-	-		FOG0000396
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720