DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc98D and DYNC2H1

DIOPT Version :9

Sequence 1:	NP_524541.3	Gene:	Dhc98D / 43379	FlyBaseID:	FBgn0013813	Length:	5080	Species:	Drosophila melanogaster
Sequence 2:	NP_001073932.1	Gene:	DYNC2H1 / 79659	HGNCID:	2962	Length:	4314	Species:	Homo sapiens

Alignment Length:	4979	Identity:	1229/4979 - (24%)
Similarity:	2099/4979 - (42%)	Gaps:	1103/4979 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 EATEFED----AIIRVPVDPKRLDLVITYTQQ-QLEEVVDGWIKYLKKTMKTLTDAKLDD----- 550
            |...|.|    .::||    :|.|..|:::.. :..:..|..:.:.|...:.:||..|.|
Human    38 EINNFLDDGNQMLLRV----QRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDENLHDNILVS 98

  Fly   551 -----------------FTPM-AEHRYWHK-MEVELYGTLEQLKTEFVVAVLQR----LT----- 587
                             |.|| .:.:.|.: .:.:|...|.:|:....: ||:|    ||
Human    99 SMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGI-VLRRSDTNLTKLKFK 162

  Fly   588 -DDKSPVL---DEWQAVVEKTEARFK-LAKENSDYLGTIIDYLEKVRSYESFKMVVLQIPNIMVG 647
             ||...:|   ||:|..:|:.....| ::||.::|...:.:.:.: ..|....:.:|::.:::..
Human   163 EDDTRGILTPSDEFQFWIEQAHRGNKQISKERANYFKELFETIAR-EFYNLDSLSLLEVVDLVET 226

  Fly   648 LR----HIW--TMSSHYCRDPEMQVL-LCQI----SNVFVQKVKSIINFENIFKYSATYTYETAT 701
            .:    .:|  |...||   ||.::| |..|    ...||||....:|.
Human   227 TQDVVDDVWRQTEHDHY---PESRMLHLLDIIGGSFGRFVQKKLGTLNL---------------- 272

  Fly   702 NCANLLRCWKQAYKLSRQHIEDSGAG----SRWEFDRVALFNEVNHIHRVAVDIAYVGRVFVQYE 762
                    |:..|.|.::.::   ||    .:|..       ..||:         .|:|:.:|.
Human   273 --------WEDPYYLVKESLK---AGISICEQWVI-------VCNHL---------TGQVWQRYV 310

  Fly   763 NLFGHRLKACIADPSIVDNLMRKVYRMLDDLIKSVDYDMFRPGNWENWEY---SLELFNKRLDNV 824
                                                     |..|:|.:|   :|:...|||:.|
Human   311 -----------------------------------------PHPWKNEKYFPETLDKLGKRLEEV 334

  Fly   825 ENEAKNVIDQSINSLLSSEKGLDLVVNAMNIDTRATLQEFVATKHENLLRFFVT---EINAVERV 886
                           |:                       :.|.||..|.|...   :|..:.||
Human   335 ---------------LA-----------------------IRTIHEKFLYFLPASEEKIICLTRV 361

  Fly   887 FTKLKKSPPM------------AKHQPAKISAIFWARLLGKKLKTSVLAFKRVEDEP-AIKNSFL 938
            |.......|:            |..|..||.|....::.| |||..:   ..::|.| .:..:||
Human   362 FEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAPAEQKIAG-KLKNYI---SEIQDSPQQLLQAFL 422

  Fly   939 KRSSFKQYFELMTVMFQFEKVLFENFIQNATYLVNTTNRSNVLRIRICKESTMSYISEAVQTLKA 1003
            |      |.||                              |.|..|.||..:..     :||.|
Human   423 K------YKEL------------------------------VKRPTISKELMLER-----ETLLA 446

  Fly  1004 KPRPELQMTSDRRVTPVKSSNLMPVQSEAFSAYSVADSAGTEISSESENE-----GLLVGDTSQK 1063
                       |.|..:|...|                       :.||.     |...|..|.|
Human   447 -----------RLVDSIKDFRL-----------------------DFENRCRGIPGDASGPLSGK 477

  Fly  1064 KLMCRINRLTVLVAMIMWMVSNTRK-ANIQLQECTAF-------------IKMVK----DKKPKD 1110
            .|...:|.: |.|..:...|.:|.| |...|.:...|             :|:.:    |...:|
Human   478 NLSEVVNSI-VWVRQLELKVDDTIKIAEALLSDLPGFRCFHQSAKDLLDQLKLYEQEQFDDWSRD 541

  Fly  1111 VTA--MDRH---CVRTCELLQRAESQYLLPIWRELVGEKTLIEYDMDFVVNLKRDVFDVLFEAQQ 1170
            :.:  .|..   |:.....:...:|...|          ..:.|....|:.|:        |.:|
Human   542 IQSGLSDSRSGLCIEASSRIMELDSNDGL----------LKVHYSDRLVILLR--------EVRQ 588

  Fly  1171 FEHLGFTLPAVLRTAIMKKDLLFKDYERMTEVVDRYRSIINNLSMSEVIFLRGHIYDTELFIQMG 1235
            ...|||.:||.:              :::..:..::        ..:.|.|:
Human   589 LSALGFVIPAKI--------------QQVANIAQKF--------CKQAIILK------------- 618

  Fly  1236 VGRYTWTSFNIGKFCDQINSQLRKLTSIVSQINFIRLDLRSRIDMIKSFNLFNLDDELKVEDTSR 1300
                     .:..|.:.|:.|:     |.||          |..|::|...|    |..::::..
Human   619 ---------QVAHFYNSIDQQM-----IQSQ----------RPMMLQSALAF----EQIIKNSKA 655

  Fly  1301 SSG-------------ESYLQDRKNPSQRFKSVTGET---ITMFSVEKDVPADEKAEQACGSGIY 1349
            .||             |.|:|..:|.::|..:...:.   .|.|
Human   656 GSGGKSQITWDNPKELEGYIQKLQNAAERLATENRKLRKWHTTF--------------------- 699

  Fly  1350 PCQGYFELLEASRNRKAAQMKKLYDSLGPVLVKLESLVLGTFSGRSDRMKTYYEYWEGETFKCIV 1414
             |:....|:.....|   |.::..|.|..:...|.::....|.. || |..:.::|..:.:|.:.
Human   700 -CEKVVVLMNIDLLR---QQQRWKDGLQELRTGLATVEAQGFQA-SD-MHAWKQHWNHQLYKALE 758

  Fly  1415 DMTYQNLKCYINRLLSNKPMFEVNAVLLMSEIVLEPSVQELQNTIVTATKDYISRLRIFTRWMTG 1479
            ......|:.    |..|.|...::.......:...|..:|::.......|.:|.
Human   759 HQYQMGLEA----LNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIG----------- 808

  Fly  1480 TCIACPLVEMGKQFKYNYTYYEDVIQIRSIVDLVINIHDLASRVANEARGFVSQFRKYFNL---- 1540
                     :..|||......::     ||..::|:         ..|.||::.|.|..:|
Human   809 ---------IPNQFKGVGEAGDE-----SIFSIMID---------RNASGFLTIFSKAEDLFRRL 850

  Fly  1541 ---------WAFEKSFICQKFLEKQVTLIEIDEK----FTFYSSIVETLANTRKFQDIKCVRINL 1592
                     |........:..:||.:..:...||    .......||.|.:..|   :.|:.||.
Human   851 SAVLHQHKEWIVIGQVDMEALVEKHLFTVHDWEKNFKALKIKGKEVERLPSAVK---VDCLNINC 912

  Fly  1593 EPLLASITQHAQDWCTTLGEELLRHVNDNMRAMRNEVKTL---------------------SLNL 1636
            .|:...|    .|....|.:.|:..:..:::|..:|:.|.                     :|..
Human   913 NPVKTVI----DDLIQKLFDLLVLSLKKSIQAHLHEIDTFVTEAMEVLTIMPQSVEEIGDANLQY 973

  Fly  1637 NKTT----------RELEDFKLVMTTIGTVQSSTLTNEQKIHEMQETFTILSE-HKIMFPYEDML 1690
            :|..          :|.||...::.|:......|::|   :....:.|.::.| |::|...:..:
Human   974 SKLQERKPEILPLFQEAEDKNRLLRTVAGGGLETISN---LKAKWDKFELMMESHQLMIKDQIEV 1035

  Fly  1691 MAHHLEKRWKRLFLSALYRYEKLQPIKQKFADMTSVEIDEFCDDLAEFIKDYDENGPGSVGAELE 1755
            |..:::.|.:      :| |::|:..|.:                      :|:..||.  ..:|
Human  1036 MKGNVKSRLQ------IY-YQELEKFKAR----------------------WDQLKPGD--DVIE 1069

  Fly  1756 RGV-RLMDPYGQKIAERESRREEL-ANAERLFDMAMVDYHEF----------ARVQTEFEGLQQL 1808
            .|. ..:|...:.|.|::...::| ...::|.|    |.|.|          :.:..:.|...|:
Human  1070 TGQHNTLDKSAKLIKEKKIEFDDLEVTRKKLVD----DCHHFRLEEPNFSLASSISKDIESCAQI 1130

  Fly  1809 YKLYKA-----QKYAREGWGKTLWADLDPNVLTEGVESYL-KEF-----RKFTKAVRTLPVGVQL 1862
            :..|:.     |:.|.|.|            :|...::|| :||     .:..|......:.|:|
Human  1131 WAFYEEFQQGFQEMANEDW------------ITFRTKTYLFEEFLMNWHDRLRKVEEHSVMTVKL 1183

  Fly  1863 EIHMKQFKGTVPLMVSLKHEALRERHWLQLMEKTGQYFDMSPARFTLENMFAMQLHKYQEIAEQI 1927
            :..:.::|..:|::..::.|.|...|||.|....|     .|...:||.:....|.:   :|:.|
Human  1184 QSEVDKYKIVIPILKYVRGEHLSPDHWLDLFRLLG-----LPRGTSLEKLLFGDLLR---VADTI 1240

  Fly  1928 LTNA--IKELQIE-------RGVQAVIETWASMAFKTFKHFKGSDDR------GWVLGPVDEIMQ 1977
            :..|  :|:|...       |.....::.|...|..|...::.|..|      .|     .:|:.
Human  1241 VAKAADLKDLNSRAQGEVTIREALRELDLWGVGAVFTLIDYEDSQSRTMKLIKDW-----KDIVN 1300

  Fly  1978 ILEDNAMNLQSMGASQFIGPFLETVNKWERTLALISEIIDEWLVVQRKWLYLEGIFIGGDIRTQL 2042
            .:.||...|||:..|.:...|.:.|:.|||.||.:.|.:.....:||||:|||.||..|    .|
Human  1301 QVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWVYLEPIFGRG----AL 1361

  Fly  2043 PEEARKFDDIDKSYRRIMVDCAKNPLVVPFCTVPGRLVEIQGLGIGLENCQKSLNEYLDSKRRIF 2107
            |:|..:|:.:|:.:|.||.|..|:..|....|..|....:..:...|:.|||||||:|:.||..|
Human  1362 PKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQKSLNEFLEEKRSAF 1426

  Fly  2108 PRFYFISTDELLSILG-SSEPSAVQNHIIKMYDNIKSLRLVKEGSQTIVTGMISSEGEVMEFRHS 2171
            ||||||..|:||.||| |:.||.:|:|:.|::..|.|:...::...  :|.|.|.||||:.|::.
Human  1427 PRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCFDEKSKH--ITAMKSLEGEVVPFKNK 1489

  Fly  2172 ARAAGRVEYWMNDVLDEMRRSNRFINKTAIYDFGTDLQISRPDWLMNYQGMV--GLAASQVWWTA 2234
            ...:..||.|:||:..||:::...:.|..:    |..:.|        ||.|  .|..||:...|
Human  1490 VPLSNNVETWLNDLALEMKKTLEQLLKECV----TTGRSS--------QGAVDPSLFPSQILCLA 1542

  Fly  2235 EVEEAFDQAQNHGNMRAMKDFLGKNNYQIE-ELVLKVRS----NLSRND---------RLKFKAQ 2285
            |..:..:..:|     |:||   .:.:||| :||.|:..    :.|..|         .||.||.
Human  1543 EQIKFTEDVEN-----AIKD---HSLHQIETQLVNKLEQYTNIDTSSEDPGNTESGILELKLKAL 1599

  Fly  2286 CTVDVHARDIIDNFVRDNVLDASEFSWESQLRFYWIKFYDNLHVLQCSGSFDFGYEYMGLNGRLV 2350
            ....:|..|::....:..|....:::|:.||||| :|......|......|.:.|||.|...:||
Human  1600 ILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFY-MKSDHTCCVQMVDSEFQYTYEYQGNASKLV 1663

  Fly  2351 ITPLTDRIYLTITQALLMNLGGAPAGPAGTGKTETVKDLAKAMGLLCVVTNCGEGMDYRAVGTIL 2415
            .|||||:.|||:|||:.|.|||.|.|||||||||:||.|...:|...:|.||.||:|.:::|.|.
Human  1664 YTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFNCDEGIDVKSMGRIF 1728

  Fly  2416 SGLVQCGAWGCFDEFNRIDISVLSVISTQLQTIRNGLIRKLDRFVFE--GVEIHLDPKCGVFVTM 2478
            .|||:||||||||||||::.||||.:|.|:|||::.|  |..|.|.|  |.|:.::...|:|:||
Human  1729 VGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDAL--KNHRTVCELLGKEVEVNSNSGIFITM 1791

  Fly  2479 NP---GYAGRTELPESVKALFRPVTCIKPDLELICLISLFSDGFLTAKVLAKKMTVLYSLAQAQL 2540
            ||   ||.||.:||:::|.|||||....||.|||..:.|:|:||..||||::|:..:::|::..|
Human  1792 NPAGKGYGGRQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEGFKDAKVLSRKLVAIFNLSRELL 1856

  Fly  2541 SKQCHYDWGLRSLNSVLRMAGVMKRQ------SEDLPEAVVLMRVLRDMNFPKFVFEDVPLFLGL 2599
            :.|.|||||||:|.:|||.:|.:.||      :::..|:.::::.||.....||.|.|...|..|
Human  1857 TPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANESHIVVQALRLNTMSKFTFTDCTRFDAL 1921

  Fly  2600 IKDLFPGIDCPRIGYPDFNAAVRHVLVNDGYILLPDQEDKVVQMYETMMTRHSTMLVGPTGGGKT 2664
            |||:||||:...:.|.:.:||::.|.....|.::|:|..|.:::||.:..|...::|||:|.||:
Human  1922 IKDVFPGIELKEVEYDELSAALKQVFEEANYEIIPNQIKKALELYEQLCQRMGVVIVGPSGAGKS 1986

  Fly  2665 VVINALVKAQTHMGLPTKCLVLNPKACSVIELYGFLDMETRDWIDGLFSNIFREMNKPIEREERR 2729
            .:...|..|....|...|...:||||....:|.|.:||:||:|.||:.:|..|::.:..:.....
Human  1987 TLWRMLRAALCKTGKVVKQYTMNPKAMPRYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSW 2051

  Fly  2730 YACFDGDVDALWIENMNSVMDDNKLLTLANGERIRLENYCALLFEVGNLNYASPATVSRAGMVYV 2794
            ..| |||:|..|||::|||:|||:|||:.:||||:.......:||..:|:.|||||:||.||:::
Human  2052 IIC-DGDIDPEWIESLNSVLDDNRLLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFL 2115

  Fly  2795 DPKNLRYSPFWQRWVLTRPEPQRELL----NDFFEKIITQSIAFILEGLDGTTQGNPLKLVIMQT 2855
            ..:....:...:.|:..:|...|..|    .|:|||    ::.::|:..|...:.:     ::.|
Human  2116 SDEETDLNSLIKSWLRNQPAEYRNNLENWIGDYFEK----ALQWVLKQNDYVVETS-----LVGT 2171

  Fly  2856 DLNMVTQF--CNLYDALLPNYVMDSKNYDEPVQQNYNTDS-LECCFLQAVYGSMGACLVEKHQPV 2917
            .:|.::..  |..:|..:.|.:       ..:..|.|..| ||  |.:.|:........:.|:|:
Human  2172 VMNGLSHLHGCRDHDEFIINLI-------RGLGGNLNMKSRLE--FTKEVFHWARESPPDFHKPM 2227

  Fly  2918 ---FDEYMKRISGFPL--VQDTPENPASGG------QFPQSKPTLYDYFWDVKDNVWKAWEWVVQ 2971
               :|....|::.:.|  .:|...:..|.|      |.|..:..| |||        |.|
Human  2228 DTYYDSTRGRLATYVLKKPEDLTADDFSNGLTLPVIQTPDMQRGL-DYF--------KPW----- 2278

  Fly  2972 PYTHDPQVKFSEILVPTVDNTRTNRTLSLMSEIKRPVLLVGEAGTSKTATIMQY----LRNLNPS 3032
                                        |.|:.|:|.:|||..|..| ..:::|    ||:..
Human  2279 ----------------------------LSSDTKQPFILVGPEGCGK-GMLLRYAFSQLRSTQ-- 2312

  Fly  3033 VNVILNINFSSRTSSLDVQHTLE------AAVEKRTKDTYGPPMGKRIACFIDDMNMPQVDDYGT 3091
               |..::.|::|:|   :|.|:      ..:...|...|.|...:|:..::.|:|:|::|.:||
Human  2313 ---IATVHCSAQTTS---RHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGT 2371

  Fly  3092 QQPIALLKLFFERGGMYDRDKDLNWKKFKDLTFYAAMGTAGG--GRNEVDPRFISMFSTYNIIFP 3154
            ...:|.|:......|.|  |::|.|...:::...|:| :|||  ||:::..||.|:....:|.:|
Human  2372 STLVAFLQQVLTYQGFY--DENLEWVGLENIQIVASM-SAGGRLGRHKLTTRFTSIVRLCSIDYP 2433

  Fly  3155 NDESLIQIYSSI--------FKGHMVFVKFQPEYMLIADMIVHMTLKLFKMVIVDLPPTPSKF-- 3209
            ..|.|..||.:.        .|.|.::......|:|...|:     ::::.|       .:||
Human  2434 EREQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMV-----QVYEQV-------RAKFTV 2486

  Fly  3210 ----HYIFNLKDLSRIFAGMLLIEPTCFKG------LRDLIRVWRNEYTRIICDRLITDNDI--- 3261
                ||.|....|::...|:...:   .:|      |..::.:...|..|:..|:::...::
Human  2487 DDYSHYFFTPCILTQWVLGLFRYD---LEGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLF 2548

  Fly  3262 -------------ANVRRNLAVEVAERFPPTFEEEHGFIDAAAAEAEAQARLLYEPSKADIDGGE 3313
                         :::..|:    ::.|..|:...|
Human  2549 DIILTSVFQGDWGSDILDNM----SDSFYVTWGARH----------------------------- 2580

  Fly  3314 EEGEEEEEGEEAP---QVILSLKDYVLRDPLLFGDFRNFTNESEPRLYEDLLDYNSVYFLFTEIL 3375
            ..|.....|:..|   :.:..|....|:|.:..|                              |
Human  2581 NSGARAAPGQPLPPHGKPLGKLNSTDLKDVIKKG------------------------------L 2615

  Fly  3376 EEYCERKQKMTLVLFEDCLEHLTRVHRTLRMNRGHVLLIGVGGSGKKCITRLAAFAAECDVFEIT 3440
            ..|....|.:.::||.:.||:::|:.|.|....|.:||.|..|.|::.||.|.:......:|...
Human  2616 IHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFSPK 2680

  Fly  3441 ISRGYNEAAFREDLKVLYTIAGVKRKKVVFLFTGAQVAEEGFLELINNILTVGQVPALFPDEDKD 3505
            |||||....|:.|||.:..:||::.::||.|....|.....|||:||::|:.|:||.|:..|:.:
Human  2681 ISRGYELKQFKNDLKHVLQLAGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELE 2745

  Fly  3506 GIVNQVRKFAEEDGVSASKDAVWGYFLRTCAENLHVVLCMSPAGDALRNRCRNFPGLIGSTYIDW 3570
            .::..::..|.:||...   .|:.||.....:|||:||.|..|.......|.:.|.|.....:.|
Human  2746 PLLLPLKDQASQDGFFG---PVFNYFTYRIQQNLHIVLIMDSANSNFMINCESNPALHKKCQVLW 2807

  Fly  3571 VFPWPRQALYAVAKLFLTE----HRLIPASHREA---------IVEHVVHVHTSIQQYSKDYLAK 3622
            :..|...::..:.::..:|    .:......:|.         .::..:.:|.|.:.|.
Human  2808 MEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKSFLLIHESCKAYG------ 2866

  Fly  3623 LRRNNFVTPKHYLDYINTYRGLLEEKAKFITQQRSRLGEGIKKIEEASVQIDELRIIVTEQKKNV 3687
                  .||..|:.:::.|..:...|.|.:.:::|.|..|:.|:.||...:|||.....||...:
Human  2867 ------ATPSRYMTFLHVYSAISSSKKKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSVLL 2925

  Fly  3688 AVASEECEAMLVTIESSTQKANVKKAEASEKSVEVEIKGKQIAIE-------KDEAEEILAEAMP 3745
            ....:|.:|.|..|..|.|       :|||:..|:|....:||.|       |::.::.|.|..|
Human  2926 KTKQDEADAALQMITVSMQ-------DASEQKTELERLKHRIAEEVVKIEERKNKIDDELKEVQP 2983

  Fly  3746 ALEEARLALSQLEKAQITEIRSFATPPAAVQVVCECVAILKGYKEINWKSAKGMMSDVNFLKSLM 3810
            .:.||:||:..::...::||||...||..::.:.|.|..|.|..:.:|.|.|..::.....:.:.
Human  2984 LVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIA 3048

  Fly  3811 EMDCEALTQKQITQCRQHMKTGNL-----EDMAKISVAGAGLLRFVRAVLGFFDVYKEVKPKKER 3870
            ..|...:: |:|.:..:.:...|.     ::..:.|.|.|.|..:|:|.:.:..|.:.:.|
Human  3049 TFDARNIS-KEIRESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHP---- 3108

  Fly  3871 LDFLVEEQEVQIKLLNHLNGEIQKLEEKLN-------ELNENYATSMKQMRALTEMMQQAERRLI 3928
               |..||......|.......:||||.||       ||.|.:.:...:...|...:.:|:..:.
Human  3109 ---LETEQAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIK 3170

  Fly  3929 ASDKLISGLTSELIRWSKEMASLGQQLIDSVGGCLISASFLAYTGAFTWEFRKAMVFDDWLEDIA 3993
            |::.||:.|..|..||:.::..:.::|........::|:|:.|..|.....||..: ::|.:
Human  3171 AAEVLINQLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYLSAAPESLRKTCL-EEWTK--- 3231

  Fly  3994 SLGIPIQLPFKIDGYLTTDVEISQWSNEGLPPDELSIQNGILTMRA------SRF-PLCIDPQLQ 4051
            |.|:.   .|.:..:|.|:.|...|.:||||.|:|||:|.::.::.      ||. |..|||..|
Human  3232 SAGLE---KFDLRRFLCTESEQLIWKSEGLPSDDLSIENALVILQIIGLKSWSRVCPFLIDPSSQ 3293

  Fly  4052 ALQWIRKREFKNNLKVLSFSDSDFLKQLEMAIMYGTPVLFEDVDDYIDPVIDDILQKNIRIQGGR 4116
            |.:|::.....:.|:|::..||:|:..||:|:.:|..::.:::|. ::||:..:|::::..||.|
Human  3294 ATEWLKTHLKDSRLEVINQQDSNFITALELAVRFGKTLIIQEMDG-VEPVLYPLLRRDLVAQGPR 3357

  Fly  4117 KFVMLGDKEVDWDPSFRVYLTTKFSNPKFDPAVYAKALVINYTVTQTGLEDQLLSVVVGTERPDL 4181
            ..|.:|||.:|::..||::|:|:..||...|...:....:|:|.|::||..|||::.:..|:|||
Human  3358 YVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDL 3422

  Fly  4182 EAQRESLIAQTSENKQLLQQLEDSLLRELSTSTGNMLDNVELIETLENTKTKAGVVMEQLKLAAD 4246
            |.|:..|:.|..:.|..|.:||:|||..|:||.||:|:|.:|||:|..||..:.::.|.||.:..
Human  3423 EEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNILENKDLIESLNQTKASSALIQESLKESYK 3487

  Fly  4247 TAADIEVLRNGYRPAAKRGAVLFFALSDMATVNSMYQYALAAYLDVFVYSLRKAVPDASLNKRLN 4311
            ....::..|:.|.|.|:..:.::|.:||::.:|:||:::|||:|.:|..:|:......:..:|:.
Human  3488 LQISLDQERDAYLPLAESASKMYFIISDLSKINNMYRFSLAAFLRLFQRALQNKQDSENTEQRIQ 3552

  Fly  4312 NIIKTLTENVYCYGCTGIFERHKLLFSFQIATKLAQRDGILLQSELDFF---IKGSIALTKSE-- 4371
            ::|.:|...||.|.|..:|:..:|:|:.....  .....:..::|.|.|   :.|.: |.|::
Human  3553 SLISSLQHMVYEYICRCLFKADQLMFALHFVR--GMHPELFQENEWDTFTGVVVGDM-LRKADSQ 3614

  Fly  4372 ---RSNPCKWL-SEKSWEDVLKLAFDFPDIFGTL--PDHFGRYLTEWKEWFDLENPEEVPCPGDY 4430
               |.....|: .|:||. |..|....|.::.||  .|     ...|:.:::....|: ..|...
Human  3615 QKIRDQLPSWIDQERSWA-VATLKIALPSLYQTLCFED-----AALWRTYYNNSMCEQ-EFPSIL 3672

  Fly  4431 NIKCNAFQKLMFLRCFRVDRIFRSINQYIVETMDEFYIMPPVVSFSAIYEQTSSTIPVCFVLSAG 4495
            ..|.:.||:::.::..|.||:..::..:..:|:....:.|..::...:|::|....|:..::|.|
Human  3673 AKKVSLFQQILVVQALRPDRLQSAMALFACKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPG 3737

  Fly  4496 SDPTNDLIKLADTIVGMSNFCHISLGQGQEKAALRLLDGAIKQGMWLMLQNGHLLIRFVRELEKH 4560
            :||:.:|.:||:.......:..:::||||...|:::|....:.|.||.|:|.||::.::..|||.
Human  3738 ADPSQELQELANAERSGECYHQVAMGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKE 3802

  Fly  4561 LDRIENPHPDFRLWITTDPTPTFPIGILQKSLKVVTEPPNGLKLNLRSTYFKVRQERLESCSHVA 4625
            |:.:: |...||||:|.:..|.|...:||.|||:..|.|.|||.||..||.....|::....:..
Human  3803 LNTLQ-PKDTFRLWLTAEVHPNFTPILLQSSLKITYESPPGLKKNLMRTYESWTPEQISKKDNTH 3866

  Fly  4626 FRPLVYVLAFFHAVVQERRKYDKLGWNIAYDFNDTDFDVCTEILRTYLTRCGTGKIPWNSLKYLI 4690
            ....::.||:|||..||||.|...||...|:|:.:|......|:.....  |...:.|..:..|:
Human  3867 RAHALFSLAWFHAACQERRNYIPQGWTKFYEFSLSDLRAGYNIIDRLFD--GAKDVQWEFVHGLL 3929

  Fly  4691 GEVMYGGRVIDDFDRRITNCYMNEYMGDFLFDEF------KVFHFYEDDNVDYCLPEEETILKED 4749
            ...:||||:.:.||.|:...|:.::....:.|.|      .:|.:      ...||:..:||  |
Human  3930 ENAIYGGRIDNYFDLRVLQSYLKQFFNSSVIDVFNQRNKKSIFPY------SVSLPQSCSIL--D 3986

  Fly  4750 YIAHIDKLPLVNKPDVFGLHPNAEIGYYTMAARNIWNSLIELQPQTGEG-TGGISRDDFIDSVAA 4813
            |.|.|:|:|..:||..|||..|.......|.:..:.:.|..|    |.. |.|...|..|.|
Human  3987 YRAVIEKIPEDDKPSFFGLPANIARSSQRMISSQVISQLRIL----GRSITAGSKFDREIWS--- 4044

  Fly  4814 GILKKLPPAFETWRIRKQ----IQMSLSP------TGVVLLQELDRFNL--LVVRIKKTLELLRK 4866
               .:|.|....|:...|    |...:.|      :.::....|::||.  ||..:.::|..|.|
Human  4045 ---NELSPVLNLWKKLNQNSNLIHQKVPPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLAALSK 4106

  Fly  4867 AIAGEIGMDNVLDNIANSLFNGLLPAAWSKLAPATCKQLASW------LEHLR---LRAVQYKYW 4922
            .|.|...:.:.:..:|::|.|...|.||.          :.|      |::||   .||:..:.|
Human  4107 VIRGTTLLSSEVQKLASALLNQKCPLAWQ----------SKWEGPEDPLQYLRGLVARALAIQNW 4161

  Fly  4923 TLSGEPLVMW-----LSGLHIPQSYLTALVQIACRRNAWPLDRSTLFTYVTKFADPDDVEERPVT 4982
            ....|...:.     ||.|..|.::|.||.|...|.....:| |..|....|    ..::|..:.
Human  4162 VDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVD-SLKFVASWK----GRLQEAKLQ 4221

  Fly  4983 GCLVHGLYIEGGRFD---LATNQL-ARSHPKVL------VEELAILAVEPIEAHRLKLQNTYLAP 5037
             ..:.||.:||..||   |:.||| :.|...||      :.:.|.....|.|...|        |
Human  4222 -IKISGLLLEGCSFDGNQLSENQLDSPSVSSVLPCFMGWIPQDACGPYSPDECISL--------P 4277

  Fly  5038 VYTTSLRRNAMGVGLVFEANLATSEDLSHWILQGVCLTL 5076
            |||::.|..     :|...::....:...||..|..|.|
Human  4278 VYTSAERDR-----VVTNIDVPCGGNQDQWIQCGAALFL 4311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc98D	NP_524541.3	DHC_N1	523..983	CDD:285571	94/532 (18%)
		DHC_N2	1798..2201	CDD:285579	126/429 (29%)
		P-loop_NTPase	2338..2565	CDD:304359	121/231 (52%)
		P-loop_NTPase	2654..2788	CDD:304359	54/133 (41%)
		P-loop_NTPase	2976..3246	CDD:304359	66/301 (22%)
		P-loop_NTPase	3378..3645	CDD:304359	72/279 (26%)
		MT	3658..3989	CDD:289543	86/349 (25%)
		AAA_9	4017..4233	CDD:289547	83/222 (37%)
		Dynein_heavy	4374..5068	CDD:281078	193/739 (26%)
DYNC2H1	NP_001073932.1	Stem. /evidence=ECO:0000250	1..1650		416/2065 (20%)
		DHC_N1	162..639	CDD:285571	129/759 (17%)
		DHC_N2	1120..1519	CDD:285579	126/429 (29%)
		P-loop_NTPase	1651..1881	CDD:304359	121/231 (52%)
		AAA 1. /evidence=ECO:0000250	1651..1875		119/225 (53%)
		P-loop_NTPase	<1937..>1988	CDD:304359	16/50 (32%)
		AAA 2. /evidence=ECO:0000250	1938..2161		77/227 (34%)
		AAA_5	1974..2110	CDD:285029	55/136 (40%)
		AAA 3. /evidence=ECO:0000250	2251..2505		73/319 (23%)
		P-loop_NTPase	2285..2494	CDD:304359	58/232 (25%)
		AAA 4. /evidence=ECO:0000250	2617..2863		67/248 (27%)
		P-loop_NTPase	2618..>2829	CDD:304359	64/213 (30%)
		Stalk. /evidence=ECO:0000250	2881..3169		75/302 (25%)
		MT	2897..3229	CDD:289543	86/347 (25%)
		AAA_9	3253..3474	CDD:289547	83/221 (38%)
		Dynein_heavy	3622..4303	CDD:281078	193/737 (26%)
		AAA 6. /evidence=ECO:0000250	3697..3912		68/215 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810