DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc98D and DNAH7

DIOPT Version :9

Sequence 1:	NP_524541.3	Gene:	Dhc98D / 43379	FlyBaseID:	FBgn0013813	Length:	5080	Species:	Drosophila melanogaster
Sequence 2:	NP_061720.2	Gene:	DNAH7 / 56171	HGNCID:	18661	Length:	4024	Species:	Homo sapiens

Alignment Length:	4205	Identity:	1315/4205 - (31%)
Similarity:	2132/4205 - (50%)	Gaps:	466/4205 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1094 QECTAFIKMVK--DKKPKDVTAMDRHCVRTCELLQRAESQYLLPIWRELVGEKTLIEYDMD--FV 1154
            |...:|...||  |:.|:..:..:          :::.::|:     |..|:|..:.:.:|  :|
Human    56 QAAPSFHLSVKQDDESPEPFSVKN----------EQSHAEYM-----ERFGKKGKLPHQVDDSYV 105

  Fly  1155 ----------------VNLKRDVFDVLFEAQQFEHL------GFTLPAVLRTAIMKKDLLFKDYE 1197
                            .|.:..:.:|:.  ||...|      |.|:|....:|| :||:|
Human   106 GPSTSKSKGKSPHKERENFRSTLVNVIM--QQDADLDSAVPDGSTIPKPTASAI-EKDIL----- 162

  Fly  1198 RMTEVVDRYRSIINNLSMSEVIFLRGHIYDTELFIQMGVGRYTWTSF-------NIGKFCDQI-- 1253
                   ||...|:            |..||:....|   ..:|...       ::..|.|.|
Human   163 -------RYYYYIH------------HGIDTDHVAPM---EDSWLEHVLDLVPQHLKVFTDSIVT 205

  Fly  1254 -NSQLRK--LTSI-VSQINFIRLDLRSRIDMIKSFNLFNLDDEL-----------KVEDTSRSSG 1303
             :.::|:  |.|: .|.::|:..|.|.:.|..|:       |||           |....|..:.
Human   206 LSDEMREDYLLSVRKSIVDFVLKDPREKGDDKKT-------DELPAHRAEMEILPKPWRKSFLAA 263

  Fly  1304 ESYLQDR---KNPSQ---------RFKSVTGETITMFSVEKDVPADEKAEQACGSGIYPCQGYFE 1356
            .||::|.   .||:.         .||.:....|..|                    :.||...|
Human   264 SSYIRDHLNAMNPTMLAVLDLWHTNFKKLRLVDIKEF--------------------HNCQDALE 308

  Fly  1357 LLEASRNRKAAQMKKLYDSLGPVLVKL---------------ESLVLGTFSGRSDRMKTYYEYWE 1406
             |.:.:|.....|    ||....|:|:               :.|..|..|.:.:..
Human   309 -LSSFQNIIMRHM----DSAKETLLKMWFPEVQNIYYQGNKKKQLPTGDSSAKLESF-------- 360

  Fly  1407 GETFKC--------IVDMTYQNLKCYINRLLS--------NKPMFEVNAVLLMSEIVLEPSVQE- 1454
               |.|        :.|:|..:::.:.:.:..        ..|.|.:..:|....|..||.:.:
Human   361 ---FNCAAALMTLQLQDLTLVSMQDFTDLIAQPPDSVRAFEHPGFIMRLILDNDTIKFEPELSDY 422

  Fly  1455 ------LQNTIVTATKDYISRL--RIFTRWMTGTCIACPLVEMGKQFKYNYTYYEDVIQIRSIVD 1511
                  :.:.::.|. .::.|:  :::::|               :.|...|..:.:| :..|||
Human   423 IDIFLNVYDVMIKAV-SFVPRVETKLYSKW---------------ESKSKPTTLKPII-LNEIVD 470

  Fly  1512 L-VINIHDLASRVANEARGFVSQFRKYFNLWAFEKSFICQKFLEKQVTLIEIDEKFTFYSSIVET 1575
            . ...|.::..:.:......:..:.||..|...:.......||.:..:..:|.::...|..::|.
Human   471 AHKEKIKEVIMKESVAPTEHLRLYDKYDFLITRKAERDVDNFLAENHSYEKIIDEICKYQKLIEE 535

  Fly  1576 LANTRKFQDIKCVRINL-----EPLLASITQHAQDWCTTLGEELLR---HVNDNMRAMRNEVKTL 1632
            :    ::..||.:|:.:     |.|:.::.:.|...|..|..::.|   .||..:......:...
Human   536 I----QYTSIKTIRLGMFEMHCEELIRALVKRADIICGKLLAKMFRDHQEVNTRLCDEFERIAEK 596

  Fly  1633 SLNLNKTTRELEDFKLVMTTIGTVQSSTLTNEQKIHEMQETFTILSEHKIMFPYEDMLMAHHLEK 1697
            :|:....|.||.:.|..:..:.......|  ||::.:.:.....|.|: :.|...||.:.:.:.:
Human   597 ALSTPPNTAELMEMKAYIQKVEVTDMIEL--EQRLVDSKNCLAFLIEY-VNFSPADMRLNNSVFQ 658

  Fly  1698 RWKRLFLSALYRYEKLQPIKQK---FADMTSVEIDEFCDDLAEFIKDYDENGPGSVGAELERGVR 1759
            .:.|  :..::. |..:.||:|   :.:...:..:.|.::|..:.|..:|........:::|.::
Human   659 WYGR--MGEIFE-EHRKIIKEKIEQYQEGLKLRCERFVEELESYAKQSEEFYSFGDLQDVQRYLK 720

  Fly  1760 LMDPYGQKIAERESRREELANAERLFDMAMVDYHEFARVQTEFEGLQQLYKLYK-AQKYAR--EG 1821
            .......|:.....:.|:....|..|......|.:..::|   :||....:||: |.:::.  ..
Human   721 KAQILNGKLDLAADKIEQFNAEEEAFGWLPSVYPQRKKIQ---DGLNPYLRLYETAVEFSSNYRA 782

  Fly  1822 WGKTLWADLDPNVLTEGVESYLKEFRKFTKAVRTLPVGV----QLEIHMKQFKGTVPLMVSLKHE 1882
            |.:..:..::|:.:...:.:|.:...|..|.....|..:    ::...::.||..:||:..:.:.
Human   783 WTEGPYHKVNPDQVEADIGNYWRGLYKLEKTFHDSPYALAMTKKVRSKVEDFKQHIPLIQVICNP 847

  Fly  1883 ALRERHWLQLMEKTGQYFDMSPA-RFTLENMFAMQLHKYQEIAEQILTNAIKELQIERGVQAVIE 1946
            .||.|||..:....|  :.:.|: ..|:.:...|.|..|.:..|.|...|.||..:|:.::.:|.
Human   848 GLRPRHWEAMSAIVG--YPLQPSDDSTVSSFLDMNLEPYIDRFEGISEAASKEYSLEKAMEKMIT 910

  Fly  1947 TWASMAFKTFKHFKGSDDRGWVLGPVDEIMQILEDNAMNLQSMGASQFIGPFLETVNKWERTLAL 2011
            .|.::.|....:   .:...::|..||||..:|:|:.:..|:|..|.||.|:.:.:.:||..|.|
Human   911 EWDAVEFVIHSY---RETGTFILASVDEIQMLLDDHIIKTQTMRGSPFIKPYEKQMREWEGKLLL 972

  Fly  2012 ISEIIDEWLVVQRKWLYLEGIFIGGDIRTQLPEEARKFDDIDKSYRRIMVDCAKNPLVVPFCTVP 2076
            :.||:||||.||..|||||.||...||.:|:|||.|:|..:||::|.||....::..|:...|:.
Human   973 LQEILDEWLKVQATWLYLEPIFSSPDIMSQMPEEGRRFTAVDKTWRDIMRSVMQDKHVLTVVTID 1037

  Fly  2077 GRLVEIQGLGIGLENCQKSLNEYLDSKRRIFPRFYFISTDELLSILG-SSEPSAVQNHIIKMYDN 2140
            ..|..::.....||...|.|||||:.||..||||:|:|.||||.||. :.:|:.||.|:.|.::.
Human  1038 RMLERLKKSNELLELILKGLNEYLEKKRLFFPRFFFLSNDELLEILSETKDPTRVQPHLKKCFEG 1102

  Fly  2141 IKSLRLVKEGSQTI-VTGMISSEGEVMEFRH---SARAAGRVEYWMNDVLDEMRRSNRFINKTAI 2201
            |..:    |.::|: :|.|.||||||:|...   :|:|.|:||.|:.::...|..|...:...|.
Human  1103 IAKV----EFTETLDITHMKSSEGEVVELIEIISTAKARGQVEKWLVELERVMINSIHKVTGDAT 1163

  Fly  2202 YDFGTDLQISRPDWLMNYQGMVGLAASQVWWTAEVEEAFDQAQNHGNMRAMKDFLGKNNYQIEEL 2266
            :.:   .:..|.:|:.::.|...|..||::||.||:.|...     .::|::.:|...|.||:::
Human  1164 FAY---TKYERINWVRDWPGQTVLCVSQIFWTKEVQTAIPM-----GIKALEQYLKTCNRQIDDI 1220

  Fly  2267 VLKVRSNLSRNDRLKFKAQCTVDVHARDIIDNFVRDNVLDASEFSWESQLRFYWIKFYDNLHVLQ 2331
            |..||..||..:|:...|...:||||||::.:.|:.|:.|.|:|.|.||||:||.:  ::|....
Human  1221 VTLVRGKLSMQNRVTLGALVVLDVHARDVLSSLVKKNISDDSDFEWLSQLRYYWQE--NHLETKM 1283

  Fly  2332 CSGSFDFGYEYMGLNGRLVITPLTDRIYLTITQALLMNLGGAPAGPAGTGKTETVKDLAKAMGLL 2396
            .:....:||||:|.:.||||||||||.|.|:..||.::|||||.||||||||||.||||||:...
Human  1284 INAGLRYGYEYLGNSPRLVITPLTDRCYRTLFGALHLHLGGAPEGPAGTGKTETTKDLAKAVAKQ 1348

  Fly  2397 CVVTNCGEGMDYRAVGTILSGLVQCGAWGCFDEFNRIDISVLSVISTQLQTIRNGLIRKLDRFVF 2461
            |||.||.:|:||.|:|....||:.||||.|||||||||:.||||::.|:.||:.|:....|..:|
Human  1349 CVVFNCSDGLDYLALGKFFKGLLSCGAWACFDEFNRIDLEVLSVVAQQILTIQRGINAGADILMF 1413

  Fly  2462 EGVEIHLDPKCGVFVTMNPGYAGRTELPESVKALFRPVTCIKPDLELICLISLFSDGFLTAKVLA 2526
            ||.|:.|||.|.||:|||||||||:|||:::|||||.|..:.||..:|..|.|:|.||:||:.|:
Human  1414 EGTELKLDPTCAVFITMNPGYAGRSELPDNLKALFRTVAMMVPDYAMIAEIVLYSCGFVTARPLS 1478

  Fly  2527 KKMTVLYSLAQAQLSKQCHYDWGLRSLNSVLRMAGVMKRQSEDLPEAVVLMRVLRDMNFPKFVFE 2591
            .|:...|.|...|||.|.|||:|:|::.|||..||.:|.:..:..|.::|:|.:.|:|.|||:..
Human  1479 VKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPNENEEILLLRSIIDVNLPKFLSH 1543

  Fly  2592 DVPLFLGLIKDLFPGIDCPRIGYPDFNAAVRHVLVNDGYILLPDQEDKVVQMYETMMTRHSTMLV 2656
            |:|||.|:..|||||:..|:..|.|..||::....:....:.....:|::|:||.|:.||..|:|
Human  1544 DLPLFEGITSDLFPGVKLPKPDYNDLLAAIKDNCASMNLQMTAFFSEKILQVYEMMIVRHGFMIV 1608

  Fly  2657 GPTGGGKTVVINALVKAQTHM---GL----PTKCLVLNPKACSVIELYGFLDMETRDWIDGLFSN 2714
            |...||||.....|..|...:   ||    ..:..|||||:.::.:|||..|..:.:|.||:.:.
Human  1609 GEPFGGKTSAYRVLAGALNDICEKGLMEENKVQITVLNPKSVTMGQLYGQFDSVSHEWSDGVLAV 1673

  Fly  2715 IFREMNKPIEREERRYACFDGDVDALWIENMNSVMDDNKLLTLANGERIRLENYCALLFEVGNLN 2779
            .||.....: ..:|::..|||.|||:||||||:|:||||.|.|.:||.|::.....|:||..:|.
Human  1674 SFRAFASSV-TPDRKWLIFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSPQMNLIFEPMDLE 1737

  Fly  2780 YASPATVSRAGMVYVDPKNLRYSPFWQRWVLTRPEP----QRELLNDFFEKIITQSIAFILEGLD 2840
            .||||||||.||:|::|..|.:.|....||...|..    |:|.:...|::::..|:.||.:
Human  1738 VASPATVSRCGMIYMEPHMLGWRPLMLSWVNLLPASVSVIQKEFIMGLFDRMVPVSVEFIRK--- 1799

  Fly  2841 GTTQGNPLKLVIMQTDLNMVTQFCNLYDALLPNYVMDSKNYDEPVQQNYNTDSLECCFLQAVYGS 2905
            .|.:.:|      .:|.|:|....||.|..:.::..:.|..:...::.|:.  ||..||.::..|
Human  1800 HTKELSP------TSDTNLVRSLMNLIDCFMDDFADEVKLKERNDRETYSL--LEGIFLFSLIWS 1856

  Fly  2906 MGACLVEKHQPVFDEYMKRISGFPL---------VQDTPENPASGG---QFPQSKPTLYDYFWDV 2958
            :||...:..:..|::.::.:...|:         :|...|..:|..   .||: |.|:|||.: |
Human  1857 VGASCTDDDRLKFNKILRELMESPISDRTRNTFKLQSGTEQTSSKALTVPFPE-KGTIYDYQF-V 1919

  Fly  2959 KDNVWKAWE-WV-----VQPYTHDPQVKFSEILVPTVDNTRTNRTLSLMSEIKRPVLLVGEAGTS 3017
            .:.:.| || |:     ..|...|  |.|:||:|||:|..|.:..:.|::..::|.:.||..||.
Human  1920 TEGIGK-WEPWIKKLKEAPPIPKD--VMFNEIIVPTLDTIRYSALMELLTTHQKPSIFVGPTGTG 1981

  Fly  3018 KTATIMQYLRN-LNPSVNVILNINFSSRTSSLDVQHTLEAAVEKRTKDTYGPPMGKRIACFIDDM 3081
            |:..|..:|.| ||..:...|.||||::|::...|:.:.:.::||.|..:|||:|||:..|:||:
Human  1982 KSVYITNFLLNQLNKEIYKPLLINFSAQTTAAQTQNIVMSKLDKRRKGVFGPPLGKRMVVFVDDV 2046

  Fly  3082 NMPQVDDYGTQQPIALLKLFFERGGMYDRDKDLNWKKFKDLTFYAAMGTAGGGRNEVDPRFISMF 3146
            |||..:.||.|.||.||:.:.:....||. ||.:..|..|:....|||..|||||.|.||::..|
Human  2047 NMPAREVYGAQPPIELLRQWLDHWNWYDL-KDCSMIKLVDIQIMCAMGPPGGGRNPVTPRYMRHF 2110

  Fly  3147 STYNIIFPNDESLIQIYSSIFKGHM-VFVKFQPEYMLIADMIVHMTLKLFKMVIVDLPPTPSKFH 3210
            :...|...:|:|:..|:|.|...|: :..||..|::.:...||:.|:.|:|..:.:|.|||:|.|
Human  2111 NIITINEFSDKSMYTIFSRILTWHLEICYKFPDEFLDLTTQIVNGTMTLYKEAMKNLLPTPAKSH 2175

  Fly  3211 YIFNLKDLSRIFAGMLLIEPTCFKGLRDLIRVWRNEYTRIICDRLITDND-------IANVRRNL 3268
            |:|||:|.||:..|:.|..|...:....:.|:|.:|..|:..|||:.:.|       |..:.||.
Human  2176 YLFNLRDFSRVIQGVCLSRPETTETTEVIKRLWVHEVLRVYYDRLLDNTDRSWLINYIQEILRNY 2240

  Fly  3269 AVEVAERFPPTFEEEHGFIDAAAAEAEAQARLLYEPSKADIDGGEEEGEEEEEGEEAPQVILSLK 3333
            ..|       .|.|                  |::....|.||..|..:
Human  2241 MYE-------DFHE------------------LFQRLDFDNDGMVEADD---------------- 2264

  Fly  3334 DYVLRDPLLFGDF----RNFTNESEPRLYEDLLDYNSVYFLFTEILEEYCE-RKQKMTLVLFEDC 3393
               ||. |:|.||    |..||      |.::.|.:::..:....||||.. .|:.|.||||...
Human  2265 ---LRS-LMFCDFHDPKREDTN------YREIADVDNLRMIVEIHLEEYNNISKKPMNLVLFRFA 2319

  Fly  3394 LEHLTRVHRTLRMNRGHVLLIGVGGSGKKCITRLAAFAAECDVFEITISRGYNEAAFREDLKVLY 3458
            :||::|:.|.|:..|.|.||:||||||::.:|||||..|:..||::.||:||:...:.|||||:.
Human  2320 IEHISRISRILKQPRSHALLVGVGGSGRQSVTRLAAHMADYSVFQVEISKGYDTTEWHEDLKVIL 2384

  Fly  3459 TIAGVKRKKVVFLFTGAQVAEEGFLELINNILTVGQVPALFPDEDKDGIVNQVR-------KFAE 3516
            ........:.|||||..|:.||.|||.::|:|..|::|.||..::|..|.:::|       |..:
Human  2385 RKCAEGEMQGVFLFTDTQIKEESFLEDVSNLLNAGEIPNLFALDEKQEICDKMRQLDRQRDKTKQ 2449

  Fly  3517 EDGVSASKDAVWGYFLRTCAENLHVVLCMSPAGDALRNRCRNFPGLIGSTYIDWVFPWPRQALYA 3581
            .||   |..|::..|:..|...|||||.|||.|||.|||.|.||.|:....|||...||..||.|
Human  2450 TDG---SPIALFNMFIDHCRSQLHVVLAMSPIGDAFRNRLRKFPALVNCCTIDWFQSWPEDALQA 2511

  Fly  3582 VAKLFLTEHRLIPASH--REAIVEHVVHVHTSIQQYSKDYLAKLRRNNFVTPKHYLDYINTYRGL 3644
            ||..||.|   |..|.  |:..::.....|||....||.:..:|:|.|:|||..||:.|:|::.|
Human  2512 VASRFLEE---IEMSEEIRDGCIDMCKSFHTSTIDLSKSFFVELQRYNYVTPTSYLELISTFKLL 2573

  Fly  3645 LEEKAKFITQQRSRLGEGIKKIEEASVQIDELRIIVTEQKKNVAVASEECEAMLVTIE-SSTQKA 3708
            ||:|...:.:.:.|...|::|::.||.|:..:::.:......:.|||:|.:.|::.|| .|.:.|
Human  2574 LEKKRSEVMKMKKRYEVGLEKLDSASSQVATMQMELEALHPQLKVASKEVDEMMIMIEKESVEVA 2638

  Fly  3709 NVKKAEASEKSV--EVEIKGKQIAIEKDEAEEILAEAMPALEEARLALSQLEKAQITEIRSFATP 3771
            ..:|...:::::  |..:..|.|   |||.:..||.|:|.||.|..||..|....||.::|..:|
Human  2639 KTEKIVKADETIANEQAMASKAI---KDECDADLAGALPILESALAALDTLTAQDITVVKSMKSP 2700

  Fly  3772 PAAVQVVCECVAILKGYK--------------EINWKSAKGMMSDVNFLKSLMEMDCEALTQKQI 3822
            ||.|::|.|.:.||||.|              |..|..||.::.|:.||:||.|.|.:.:....:
Human  2701 PAGVKLVMEAICILKGIKADKIPDPTGSGKKIEDFWGPAKRLLGDMRFLQSLHEYDKDNIPPAYM 2765

  Fly  3823 TQCRQ-HMKTGNL--EDMAKISVAGAGLLRFVRAVLGFFDVYKEVKPKKERLDFLVEEQEVQIKL 3884
            ...|: ::...:.  |.:...|.|..||.::|.|:..:..|.|.|.|||.:|.....|.::.:..
Human  2766 NIIRKNYIPNPDFVPEKIRNASTAAEGLCKWVIAMDSYDKVAKIVAPKKIKLAAAEGELKIAMDG 2830

  Fly  3885 LNHLNGEIQKLEEKLNELNENYATSMKQMRALTEMMQQAERRLIASDKLISGLTSELIRWSKEMA 3949
            |......::::::||..|.:....:.::...|...:....::|..:::||.||..|..|||....
Human  2831 LRKKQAALKEVQDKLARLQDTLELNKQKKADLENQVDLCSKKLERAEQLIGGLGGEKTRWSHTAL 2895

  Fly  3950 SLGQQLIDSVGGCLISASFLAYTGAFTWEFRKAMVFDDWLEDIASLGIPIQLPFKIDGYLTTDVE 4014
            .|||..|:..|..|||:..:||.||||..:|:... .:|........||......:.|.|...|.
Human  2896 ELGQLYINLTGDILISSGVVAYLGAFTSTYRQNQT-KEWTTLCKGRDIPCSDDCSLMGTLGEAVT 2959

  Fly  4015 ISQWSNEGLPPDELSIQNGILTMRASRFPLCIDPQLQALQWIRKREFKNNLKVLSFSDSDFLKQL 4079
            |..|:..|||.|..||.|||:.|.|.|:||.||||.||.:||:..|..|:|.|:..|:.|:::.|
Human  2960 IRTWNIAGLPSDSFSIDNGIIIMNARRWPLMIDPQSQANKWIKNMEKANSLYVIKLSEPDYVRTL 3024

  Fly  4080 EMAIMYGTPVLFEDVDDYIDPVIDDILQKNIRIQGGRKFVMLGDKEVDWDPSFRVYLTTKFSNPK 4144
            |..|.:|||||.|:|.:.:||:::.:|.|....|||...:.|||..:::.|.||.|:|||..||.
Human  3025 ENCIQFGTPVLLENVGEELDPILEPLLLKQTFKQGGSTCIRLGDSTIEYAPDFRFYITTKLRNPH 3089

  Fly  4145 FDPAVYAKALVINYTVTQTGLEDQLLSVVVGTERPDLEAQRESLIAQTSENKQLLQQLEDSLLRE 4209
            :.|....|..::|:.:|..|::||||.:||..||||||.::::||.|.:|||:.|:::||.:|..
Human  3090 YLPETSVKVTLLNFMITPEGMQDQLLGIVVAQERPDLEEEKQALILQGAENKRQLKEIEDKILEV 3154

  Fly  4210 LSTSTGNMLDNVELIETLENTKTKAGVVMEQLKLAADTAADIEVLRNGYRPAAKRGAVLFFALSD 4274
            ||:|.||:|::...|:.|.::|..|..:.::.::|.:|...|:..|.||||.|...::|||:|:|
Human  3155 LSSSEGNILEDETAIKILSSSKALANEISQKQEVAEETEKKIDTTRMGYRPIAIHSSILFFSLAD 3219

  Fly  4275 MATVNSMYQYALAAYLDVFVYSLRKAVPDASLNKRLNNIIKTLTENVYCYGCTGIFERHKLLFSF 4339
            :|.:..||||:|..::::|:.|:..:.....|.|||..:....|.::|...|..:||:.||||||
Human  3220 LANIEPMYQYSLTWFINLFILSIENSEKSEILAKRLQILKDHFTYSLYVNVCRSLFEKDKLLFSF 3284

  Fly  4340 QIATKLAQRDGILLQSELDFFIKGSIALTKSERSNPCKWLSEKSWEDVLKLAFDFPDIFGTLPDH 4404
            .:...|...:..:.::|..|.:.|.|.| .:..:|.|.||.:|||:::.:|. |.| .|.|:...
Human  3285 CLTINLLLHERAINKAEWRFLLTGGIGL-DNPYANLCTWLPQKSWDEICRLD-DLP-AFKTIRRE 3346

  Fly  4405 FGRYLTEWKEWFDLENPEEVPCPGDYNIKCNAFQKLMFLRCFRVDRIFRSINQYIVETMDEFYIM 4469
            |.|....||:.:|...|.....|.::..|.|.||:::.:||.|.|::...:.::|:..:...:|.
Human  3347 FMRLKDGWKKVYDSLEPHHEVFPEEWEDKANEFQRMLIIRCLRPDKVIPMLQEFIINRLGRAFIE 3411

  Fly  4470 PPVVSFSAIYEQTSSTIPVCFVLSAGSDPTNDLIKLADTI-VGMSNFCHISLGQGQEKAALRLLD 4533
            ||....:..:..::...|:.||||.|:||...|:|.||.. .|.|....:||||||...|:::|:
Human  3412 PPPFDLAKAFGDSNCCAPLIFVLSPGADPMAALLKFADDQGYGGSKLSSLSLGQGQGPIAMKMLE 3476

  Fly  4534 GAIKQGMWLMLQNGHLLIRFVRELEKHLDRI--ENPHPDFRLWITTDPTPTFPIGILQKSLKVVT 4596
            .|:|:|.|::|||.||...::..|||..:.:  |:.|||||:|:|:.|:|.||:.:||..:|:..
Human  3477 KAVKEGTWVVLQNCHLATSWMPTLEKVCEELSPESTHPDFRMWLTSYPSPNFPVSVLQNGVKMTN 3541

  Fly  4597 EPPNGLKLNLRSTYFK---VRQERLESCSH-VAFRPLVYVLAFFHAVVQERRKYDKLGWNIAYDF 4657
            |.|.||:.|:..:|..   ...|...||.. ..|:.|:|.|.||||:||||||:..|||||.|:|
Human  3542 EAPKGLRANIIRSYLMDPISDPEFFGSCKKPEEFKKLLYGLCFFHALVQERRKFGPLGWNIPYEF 3606

  Fly  4658 NDTDFDVCTEILRTYLTRCGTGKIPWNSLKYLIGEVMYGGRVIDDFDRRITNCYMNEYM------ 4716
            |:||..:..:.|..:|.:  ..::|:.:|:|:.||..|||||.||:|||.....:|::.
Human  3607 NETDLRISVQQLHMFLNQ--YEELPYEALRYMTGECNYGGRVTDDWDRRTLRSILNKFFNPELVE 3669

  Fly  4717 -GDFLFDEFKVFHFYEDDNVDYCLPEEETILKEDYIAHIDKLPLVNKPDVFGLHPNAEIGYYTMA 4780
             .|:.||...:          |.:|....  .:.||.:...|||...|::||::.||:|......
Human  3670 NSDYKFDSSGI----------YFVPPSGD--HKSYIEYTKTLPLTPAPEIFGMNANADITKDQSE 3722

  Fly  4781 ARNIWNSLIELQPQTGEGTGGISRDDFIDSVAAGILKKLPPAFETWRIRKQIQMSLSPT------ 4839
            .:.::::::..|.::. |.|..|.|:.::.||:.||.|||..|:.     :..|...||
Human  3723 TQLLFDNILLTQSRSA-GAGAKSSDEVVNEVASDILGKLPNNFDI-----EAAMRRYPTTYTQSM 3781

  Fly  4840 GVVLLQELDRFNLLVVRIKKTLELLRKAIAGEIGMDNVLDNIANSLFNGLLPAAWSKLAPATCKQ 4904
            ..||:||:.|||.|:..|:.:...::|||.|...|...|:.:.:|:.|..:|..|...:..:.|.
Human  3782 NTVLVQEMGRFNKLLKTIRDSCVNIQKAIKGLAVMSTDLEEVVSSILNVKIPEMWMGKSYPSLKP 3846

  Fly  4905 LASWLEHLRLRAVQYKYWTLSGEPLVMWLSGLHIPQSYLTALVQIACRRNAWPLDRSTLFTYVTK 4969
            |.|::.....|....:.|...|.|.|.||||....|::||...|...|:...|:|   |..:..:
Human  3847 LGSYVNDFLARLKFLQQWYEVGPPPVFWLSGFFFTQAFLTGAQQNYARKYTIPID---LLGFDYE 3908

  Fly  4970 FADPDDVEERPVTGCLVHGLYIEGGRFDLATNQLARSHPKVLVEELAILAVEPIEAHRLKLQNTY 5034
            ..:..:.:..|..|..:|||:::|..::....:||.||||:|.:.:.::.::|.:...:..:.:|
Human  3909 VMEDKEYKHPPEDGVFIHGLFLDGASWNRKIKKLAESHPKILYDTVPVMWLKPCKRADIPKRPSY 3973

  Fly  5035 LAPVYTTSLRRNAM-----GVGLVFEANLATSEDLSHWILQGVCL 5074
            :||:|.||.||..:     ....|....|.:.:...|||.:||.|
Human  3974 VAPLYKTSERRGVLSTTGHSTNFVIAMTLPSDQPKEHWIGRGVAL 4018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc98D	NP_524541.3	DHC_N1	523..983	CDD:285571
		DHC_N2	1798..2201	CDD:285579	131/415 (32%)
		P-loop_NTPase	2338..2565	CDD:304359	130/226 (58%)
		P-loop_NTPase	2654..2788	CDD:304359	58/140 (41%)
		P-loop_NTPase	2976..3246	CDD:304359	102/271 (38%)
		P-loop_NTPase	3378..3645	CDD:304359	115/276 (42%)
		MT	3658..3989	CDD:289543	102/350 (29%)
		AAA_9	4017..4233	CDD:289547	94/215 (44%)
		Dynein_heavy	4374..5068	CDD:281078	227/718 (32%)
DNAH7	NP_061720.2	Stem. /evidence=ECO:0000250	1..1289		313/1369 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..121		12/79 (15%)
		DHC_N2	763..1162	CDD:285579	129/407 (32%)
		P-loop_NTPase	1290..1520	CDD:304359	131/229 (57%)
		AAA 1. /evidence=ECO:0000250	1290..1511		128/220 (58%)
		AAA 2. /evidence=ECO:0000250	1571..1802		84/234 (36%)
		P-loop_NTPase	1604..1747	CDD:304359	59/143 (41%)
		AAA 3. /evidence=ECO:0000250	1938..2189		98/253 (39%)
		P-loop_NTPase	1942..2211	CDD:304359	102/271 (38%)
		AAA 4. /evidence=ECO:0000250	2302..2555		107/258 (41%)
		P-loop_NTPase	2303..2574	CDD:304359	115/276 (42%)
		Stalk. /evidence=ECO:0000250	2572..2873		82/303 (27%)
		MT	2586..2933	CDD:289543	102/350 (29%)
		AAA 5. /evidence=ECO:0000250	2954..3184		98/229 (43%)
		AAA_9	2962..3178	CDD:289547	94/215 (44%)
		Dynein_heavy	3322..4012	CDD:281078	225/714 (32%)
		AAA 6. /evidence=ECO:0000250	3397..3620		87/222 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710