DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc98D and CG9068

DIOPT Version :9

Sequence 1:	NP_524541.3	Gene:	Dhc98D / 43379	FlyBaseID:	FBgn0013813	Length:	5080	Species:	Drosophila melanogaster
Sequence 2:	NP_611111.1	Gene:	CG9068 / 36817	FlyBaseID:	FBgn0034106	Length:	1227	Species:	Drosophila melanogaster

Alignment Length:	1333	Identity:	238/1333 - (17%)
Similarity:	452/1333 - (33%)	Gaps:	396/1333 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 AIIRVPVDPKRLDL--VITYTQQQLEEVVDGWIKYLKKTM--KTLTDAKLDDFTPMAEHRYW-HK 562
            :::.||...|.|..  |..|....||.:...|...::..:  .||| ...|..|...|..:| ::
  Fly   191 SVMYVPFVIKELTAGPVDRYLVGSLEGIALYWTTQIRTLLADDTLT-VPHDLVTVRDEFEFWEYR 254

  Fly   563 MEVELYGTLEQLKTEFVVAVLQRLTDDKSPVLDEWQAVVEKTEARFKLAKENSDYLGTIIDYLEK 627
            .|| |.|..:||....|..||..|.:.:|..:.:...::|:.......:..|..||..:|:...|
  Fly   255 YEV-LQGINDQLAHSDVQKVLLLLHNAQSVHMPQMDGLIERARKELHKSLSNIKYLHLLIEPCSK 318

  Fly   628 VRSYESFKMVVLQIPNIMVGLRHIWTMSSHYCRDPEMQVLLCQISNVFVQ------KVKSIINFE 686
            :.:..|...:...:|.|:..:|.||..|.:|.....:..|...:||..::      ||:.|::.:
  Fly   319 IDAATSPADLTKLLPRIIHLIRFIWLNSEYYNTTRLIAALFRNLSNQIIRFCTKQTKVEEILSGK 383

  Fly   687 NIF---------KYSATY--TYETATNCANLLRCWKQAYKLSRQHIEDSGAGSRWEFDRVALFNE 740
            ..|         :...||  .|:|.:.            .|:::|.:     ..||.|...:||.
  Fly   384 PRFGIRICNVAIECCLTYRGIYDTISR------------DLAQKHTQ-----MPWELDEGLIFNH 431

  Fly   741 VNHIHRVAVDIAYVGRVFVQYENLFGHRLKACIADPSIVDNLMRKVYRMLDDLIKSVDYDMFRPG 805
            ::              .||:       ||...|   .|.::::  |:..||
  Fly   432 ID--------------AFVE-------RLNDVI---DICESMI--VFGRLD-------------- 456

  Fly   806 NWENWEYSLELFNKRL-DNVENEAKNVIDQSINSLLSSEKGLDLVVNAMNIDTRATLQEFVATKH 869
              ||......:|.... :.:|..|::|..|.:::|...::.....:  :|:. ||.....||...
  Fly   457 --ENGSIPKPVFGGTCGEELEKIAESVEVQFLDTLNKLQQNSQAYI--LNVH-RADWYADVAGFR 516

  Fly   870 ENLLRFFVTEINAVERVFTKLKKSPPMAKHQPAKISAIFWARLLGKKLKTSVLAFKRVEDEPAIK 934
            :|:.:...|....:..||.::.....|.:...|                   :.|........::
  Fly   517 KNMQKLEETVQRLIFNVFQQVSNVEEMLEALQA-------------------MLFYSYRQRGTLR 562

  Fly   935 NSFLKRSSFKQYFELMTVMFQFEKVLFENFIQNATYLVNTTNRSNVLRIRICKESTMSYISEAVQ 999
            .::||.:|      .:..||..|              ::.|:|.     .:.::|..|::|:.|
  Fly   563 KTYLKETS------KLWRMFSKE--------------MDATSRK-----LLEEQSRESWLSKHV- 601

  Fly  1000 TLKAKPRPELQMTS---DRRVTPVKSSNLMPVQSEAFSAYSVADSAGTEISSESENEGLLVGDTS 1061
            ::....|..|:..:   ||    :|:|..:|...|:..|.:..|:...|...|
  Fly   602 SIALGYRINLERLTWLRDR----LKNSEWLPAVKESSPALAKFDALRHEFQKE------------ 650

  Fly  1062 QKKLMCRINRLTVLVAMIMWMVSNTRKANIQLQECTAFIKMVKDKKPKDVTAMDRHCVRTCELLQ 1126
                        :.:|...|:.           :|..|                     :.:|.|
  Fly   651 ------------IRLAYDDWVA-----------KCCGF---------------------SGDLCQ 671

  Fly  1127 RAESQYLLPIWRELVGEKTLIEYDMDFVVNLKRDVFDVLFEAQQFEHLGFTLPAVLRTAIMKKDL 1191
            |.: :||:...::..|   |:|      .|:...|.::..:||.||.:||.:|:.::....:.|.
  Fly   672 RLD-RYLVVRSKKFKG---LLE------CNIDASVLELCEQAQHFERMGFAIPSTMKKLYERYDT 726

  Fly  1192 LFKDYERMTEVVDRYRSIINNLSMSEVIFLRGHIYDTELFIQMGVGRYTWTS-FN---------- 1245
            :...|..:.::...:..|:..||..|....|..|...:..:..||.:.|:.| ||
  Fly   727 IRSLYNGIIKLALSHNRILAVLSDRERKLFRPLIQACDRQLAPGVFKITYGSEFNEEFFEDGTEF 791

  Fly  1246 -----------------IGKFCDQI--NSQLRKLTSIVSQINFIRLDLRSRI----DMIKSFNLF 1287
                             :.:.|::|  ...|....|....|:..:..|.||:    |:::|:.
  Fly   792 IAEFQELVLIFKRANRGVARICEKICGTCLLHFAFSGSVDISVFQQQLSSRLSSSGDILRSYY-- 854

  Fly  1288 NLDDELKVEDTSRSSGESYLQDRKNPSQRFKSV----TGETITMFSVEKDVPADEKAEQACGSGI 1348
                ...||..|..||:            |:||    :.|.|...:...|:.|......|.||
  Fly   855 ----SHVVELLSAFSGQ------------FQSVDDEMSAEWIAYVNDMDDMLASSLMTSARGS-- 901

  Fly  1349 YPCQGYFELLEASRNRKAAQMKKLYDSLGPVLVKLESLVLGTFSGRSDRMKTYYEYWEGETFKCI 1413
                                :.|||::|                                  .|.
  Fly   902 --------------------LNKLYEAL----------------------------------HCD 912

  Fly  1414 VDMTYQNLKCYINRLLSNKPMFEVNAVLLMSEIVLEP---SVQELQNTIVTATKDYISRLRIFTR 1475
            .||             ::.|:..|.:.:....||..|   ::.::.|.||.:.:   |.|..|.|
  Fly   913 ADM-------------ASAPIIVVESDVKDGRIVFTPDMDAIGDMINGIVDSIR---SMLDQFPR 961

  Fly  1476 WMTGTCIACPLVEMGKQFKYNYTYYEDVIQIRSIVDLVINIHDLASRVANEARGFVSQFRKYFNL 1540
              .|..:..|..:..:.|...:...::..::...:...|.|.      ..|...:.|::.|...|
  Fly   962 --LGYKLKLPKKQQRQGFASVFREDQECSELMRSIQAEIGIQ------REELAKYESEWNKNRVL 1018

  Fly  1541 WAFEKSFICQKFLEKQVTLIEIDEKFTFYSSIVETLANTRKFQDIKCVRINLEPLLASITQHAQD 1605
            |...:....|:.:.|..|....:.....||::.:.:.......::..:.||...|.:::....:.
  Fly  1019 WQTTEEEFRQRLMSKSRTAGVFEGGIEHYSALADDVIFEDAITNVYFILINQNALKSTMLDWIEK 1083

  Fly  1606 WCTTLGEELLRHVNDNMRAMRNEVKTLSLNLNKTTRELED-------FKLVMTTIGTVQSSTLTN 1663
            |.....:.||.|.::.|.|:...::....|:.|..|.:.:       |:.::..:...||:
  Fly  1084 WQALNIKMLLDHGSNLMGAVYRYMRRNERNVMKVPRTIRETVAAKQLFEKLLKDVPVKQSA---- 1144

  Fly  1664 EQKIHEMQETFTILSEHKIMFPYEDMLMAHHLEKRWKRLFLSALYRYEKLQPIKQKFADMTSVEI 1728
               ...|.|.|.:|.::::....|.......||..|       |:..:.|:            |.
  Fly  1145 ---FTPMLELFVLLHKYQVKLSEETFEQVMGLETAW-------LHYLQVLE------------EA 1187

  Fly  1729 DEFCDD-------------------LAEFIKDY 1742
            ||..|:                   |.:|::|:
  Fly  1188 DEMLDNEDSEAKLLLAKHGEKFKLILKDFLEDF 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc98D	NP_524541.3	DHC_N1	523..983	CDD:285571	90/480 (19%)
		DHC_N2	1798..2201	CDD:285579
		P-loop_NTPase	2338..2565	CDD:304359
		P-loop_NTPase	2654..2788	CDD:304359
		P-loop_NTPase	2976..3246	CDD:304359
		P-loop_NTPase	3378..3645	CDD:304359
		MT	3658..3989	CDD:289543
		AAA_9	4017..4233	CDD:289547
		Dynein_heavy	4374..5068	CDD:281078
CG9068	NP_611111.1	DHC_N1	211..784	CDD:285571	141/751 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000396
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.640