DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc98D and DYNC1H1

DIOPT Version :9

Sequence 1:	NP_524541.3	Gene:	Dhc98D / 43379	FlyBaseID:	FBgn0013813	Length:	5080	Species:	Drosophila melanogaster
Sequence 2:	NP_001367.2	Gene:	DYNC1H1 / 1778	HGNCID:	2961	Length:	4646	Species:	Homo sapiens

Alignment Length:	5182	Identity:	1301/5182 - (25%)
Similarity:	2234/5182 - (43%)	Gaps:	981/5182 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 GGGGAGGPAG------ETGEDIS---SEAKESGPGLLELSKPSEFRLRALKQQKKMKEK------ 378
            ||||..|.||      :...|:|   ...::..|.|||....:...|.|..::|...|:
Human     6 GGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKSALEQMRKFLS 70

  Fly   379 -----EAAAKKAKAKKTDAEPTEEEEEADAHKVEAHLS-----------------SSEEEVEIKV 421
                 ....:::..|:...:..|||:|..::.:...:.                 .:::.|..::
Human    71 DPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIKRTPVIDADKPVSSQL 135

  Fly   422 EKLTIGQRWEKMLNETKAKVEAEHA-AEEATPPRITPIQR----------RLLKEIEEFQSEITW 475
            ..||:.:         .:..|..|: ...|..|......|          ::...:|:..:|:..
Human   136 RVLTLSE---------DSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAPSVEKKIAELEM 191

  Fly   476 TINHIVWAFSLP--SSYILP------------GQ--EATEFEDAIIRVPVDPKRLDLVITYTQQQ 524
            .:.|:.....:|  |..|.|            |:  :.|:|.|.:    .||..|:        |
Human   192 GLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKV----EDPTFLN--------Q 244

  Fly   525 LEEVVDGWIKYLKKTMKTLTDAKLDDFTPMAEHRYWHKMEVELYGTLEQLKTEFVVAVLQRLTDD 589
            |:..|:.||:.::|..|  .|......|.:.|..:|..:|..||...|:.::..|:..|..|...
Human   245 LQSGVNRWIREIQKVTK--LDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHG 307

  Fly   590 KSPVLDEWQAVVE-KTEARFKLAKEN-SDYLGTIIDY----------LEKVRSYESFKMVVL--- 639
            |     .:.|.|. .|:...|.|.|. :||...:.|:          |:|:|.    .:|.:
Human   308 K-----RFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQ----ALVAIFTH 363

  Fly   640 --QIPNIMVGLRHIWTMSSHYCRDPEMQVLLCQISNVFVQKVKSIINFENIFKYSATYTYETATN 702
              :|.|....::....:.....||     |..|:..|...:....:.:|...|....
Human   364 LRKIRNTKYPIQRALRLVEAISRD-----LSSQLLKVLGTRKLMHVAYEEFEKVMVA-------- 415

  Fly   703 CANLLRCWKQAYKLSRQHIEDSGAGSRWEFDRVALFNEVNHIHR-VAVDIAYVGRVFVQYENLFG 766
            |..:.:.|...|:..:..:.|.....|.|  .:.:...:|..|| :...:..:.:...|:|.|
Human   416 CFEVFQTWDDEYEKLQVLLRDIVKRKREE--NLKMVWRINPAHRKLQARLDQMRKFRRQHEQL-- 476

  Fly   767 HRLKACIADPSIVDNLMR--------------------KVYRMLDDL---------------IKS 796
                     .:::..::|                    ||..:|.|.               :|.
Human   477 ---------RAVIVRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKE 532

  Fly   797 VD-YDMFRPGNWENWEYSLELFNKRLDNVENEAKNVIDQSINSLLSSEKGLDLVVNAM-NIDTRA 859
            || .|:.:.|. |.||.:::.:::|:|.||..        |.:.|..:.|.....|.| .|.:|.
Human   533 VDGLDVSKEGT-EAWEAAMKRYDERIDRVETR--------ITARLRDQLGTAKNANEMFRIFSRF 588

  Fly   860 TLQEFVATKHENLLRFFVTEI-----NAVERVFTKLKKSPPMAKHQPAKIS----------AIFW 909
            ... ||.......:|.:.|::     :.:|.:..|.|...|.:  |..|:|          :|.|
Human   589 NAL-FVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQYPQS--QACKMSHVRDLPPVSGSIIW 650

  Fly   910 ARLLGKKLKTSVLAFKRVED------EPAIKNSFLKR--SSFKQYFELMTVMFQF-EKVLFENF- 964
            |:.:.::|...:   |||||      |..::...||:  .||:.......:...: .||...|.
Human   651 AKQIDRQLTAYM---KRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLG 712

  Fly   965 IQNATYLVNTT----NRSNVLRIRICKESTMSYISEAVQTLK-AKPRPELQMTSDRRVTPVKSSN 1024
            :....:.:.:|    ...|||::::.....:..:|:.|:.|| ...|..|.:.:...    :::.
Human   713 VSGRIFTIESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAH----QANQ 773

  Fly  1025 LMPVQSEAFSAYSVADSAGT-EISSESENEGLLVGDTSQKKLMCRINRLTVLVAMIMWMVSNTRK 1088
            |.|.      |.|:.:|..| |.:.|...|.               |.:::|||.:        |
Human   774 LYPF------AISLIESVRTYERTCEKVEER---------------NTISLLVAGL--------K 809

  Fly  1089 ANIQ--LQECTAFIKMVKDKKPKDVTAMDRHCVRTCELLQRAESQYLLPIWRELVGEKTLIEYDM 1151
            ..:|  :.|..|.:                           .||..|.|..:.|.
Human   810 KEVQALIAEGIALV---------------------------WESYKLDPYVQRLA---------- 837

  Fly  1152 DFVVNLKRDVFDVLFEAQQFEHLGFTLPAVLRTAIMKKDLLFKDYERMTEVVDRYRSIINNLSMS 1216
            :.|.|.:..|.|:|...::.:           ..:...:....|::..:|:::|.:..:::|::
Human   838 ETVFNFQEKVDDLLIIEEKID-----------LEVRSLETCMYDHKTFSEILNRVQKAVDDLNL- 890

  Fly  1217 EVIFLRGHIY----------DTE----LFIQMGVGRYTWTSFNIGKFCDQINSQLRKLTSIVSQI 1267
                   |.|          |.|    |.:::..|...||...:|:..|
Human   891 -------HSYSNLPIWVNKLDMEIERILGVRLQAGLRAWTQVLLGQAED---------------- 932

  Fly  1268 NFIRLDLRSRIDMIKSFNLFNLDDELKVEDTSRSSGESYLQDRKNPSQRFKSVTGE-TITMFSVE 1331
                   ::.:||          |....:.:.:..||          .:.|:|..| .||...:.
Human   933 -------KAEVDM----------DTDAPQVSHKPGGE----------PKIKNVVHELRITNQVIY 970

  Fly  1332 KDVPADEKAEQACGSGIYPCQGYFELLEASRNRKAAQMKKLYDSLGPVLVKLESLVLGTFSGRSD 1396
            .:.|.:|            |:                 .|||..:  ...|:..|.|.....:..
Human   971 LNPPIEE------------CR-----------------YKLYQEM--FAWKMVVLSLPRIQSQRY 1004

  Fly  1397 RMKTYYEYWEGETFKCIVDMTYQNLKCYINRLLSNKPMFEVNAVLLMSEIVLEPSVQELQNTIVT 1461
            ::..:||..|.|.|       |:|       .|:..|         ...:.||.|...:.. ||:
Human  1005 QVGVHYELTEEEKF-------YRN-------ALTRMP---------DGPVALEESYSAVMG-IVS 1045

  Fly  1462 ATKDYISRLRIFTRWMTGTCIACPLVEMGKQFKYNYTYYEDVIQIRSIVDLVINIHDLASRVANE 1526
            ..:.|:.      .|:...|    |.:|..:..||                         |:..:
Human  1046 EVEQYVK------VWLQYQC----LWDMQAENIYN-------------------------RLGED 1075

  Fly  1527 ARGFVSQFRKYFNLWAFEKSFICQKFLEKQVTLIEIDE-KFTFYSSIVETLANTRKFQDIKCVRI 1590
                       .|.|              |..|::|.: :.||.:      |.|:|  :...|.|
Human  1076 -----------LNKW--------------QALLVQIRKARGTFDN------AETKK--EFGPVVI 1107

  Fly  1591 NLEPLLASITQHAQDWCTTLGEELLRHVNDNMRAMRNEVKTLSLNLNKTTRELEDFKL------- 1648
            :...:.:.:......|...:..:..:.:..||....:::       :|:.:|||...:
Human  1108 DYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQI-------SKSRQELEQHSVDTASTSD 1165

  Fly  1649 VMTTIGTVQSSTLTNEQKIHEMQETF-------TILSEHKIMFPYEDMLMAHHLEKRWKRLFLSA 1706
            .:|.|..|||.    ::||.:.::..       .:|.:.:..|| ...|...::|..| ..|...
Human  1166 AVTFITYVQSL----KRKIKQFEKQVELYRNGQRLLEKQRFQFP-PSWLYIDNIEGEW-GAFNDI 1224

  Fly  1707 LYRYEKLQPIKQKFAD--MTSVEIDEFCDD-LAEFIKDYDENGPGSVGAELERGVRLMDPYGQKI 1768
            :.|  |...|:|:.|:  |..|:.|...:. ..:.:.|:::..|.:.....|..::.:..|..|.
Human  1225 MRR--KDSAIQQQVANLQMKIVQEDRAVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKF 1287

  Fly  1769 AERESRREELANAE---RLFDMAMVDYHEFARVQTEFEGLQ-------QLYKLYKAQKYAREGWG 1823
            ...:..||:.|.|:   .|.|..::...| .|||...|.||       :|.|:::.....:|
Human  1288 GRLKDDREKCAKAKEALELTDTGLLSGSE-ERVQVALEELQDLKGVWSELSKVWEQIDQMKE--- 1348

  Fly  1824 KTLWADLDPNVLTEGVESYLKEFRKFTKAVRTLPVGVQLEIHMKQFKGTVP---LMVSLKHEALR 1885
             ..|..:.|..|.:.:::.|.:.:.|...:|..   ...|...:..||.:.   |::.||.|||:
Human  1349 -QPWVSVQPRKLRQNLDALLNQLKSFPARLRQY---ASYEFVQRLLKGYMKINMLVIELKSEALK 1409

  Fly  1886 ERHWLQLMEKTGQYFDMSPARFTLENMFAMQLHKYQEIAEQILTNAIKELQIERGVQAVIETWAS 1950
            :|||.|||::.  :.:...:..||..::.:.|.|.:.|.:.:|..|..|:.:|..::.:.|.|.:
Human  1410 DRHWKQLMKRL--HVNWVVSELTLGQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNT 1472

  Fly  1951 MAFKTFKH-FKGSDDRGWVLGPVDEIMQILEDNAMNLQSMGASQFIGPFLETVNKWERTLALISE 2014
            .......: .|....|||     |::...::::..::.:|..|.:...|.|....||..|..|..
Human  1473 YELDLVNYQNKCRLIRGW-----DDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMA 1532

  Fly  2015 IIDEWLVVQRKWLYLEGIFIG-GDIRTQLPEEARKFDDIDKSYRRIMVDCAKNPLVVPFCTVPGR 2078
            :.|.|:.|||:|:||||||.| .||:..||.|.::|..|...:..:|...:|:|||:....:.|.
Human  1533 LFDVWIDVQRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGV 1597

  Fly  2079 LVEIQGLGIGLENCQKSLNEYLDSKRRIFPRFYFISTDELLSILGSSEPSA-VQNHIIKMYDNIK 2142
            ...::.|...|...||:|.|||:.:|..||||||:..::||.|:|:|:..| :|.|..||:..:.
Human  1598 QRSLERLADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVS 1662

  Fly  2143 SLRLVKEGSQTIVTGMISSEGEVMEFRH--SARAAGRVEYWMNDVLDEMRRSNRFI---NKTAIY 2202
            |:.|.::.|  :|.|:.|.|||.:.|:.  |.....::..|:..|..|||.:...:   :.|.:.
Human  1663 SIILNEDNS--VVLGISSREGEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVE 1725

  Fly  2203 DFGTDLQISRPD----WLMNYQGMVGLAASQVWWTAEVEEAFDQAQNHGNMRAMKDFLGKNNYQI 2263
            .||....|. |:    |:..||..:.:.::|:.|:..||.|.......|:...:...|......:
Human  1726 IFGKATSID-PNTYITWIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTL 1789

  Fly  2264 EELVLKVRSNLSRNDRLKFKAQCTVDVHARDIIDNFVRDNVLDASEFSWESQLRFYW----IKFY 2324
            ..|...|........|.|.:...|..||.||:..:.::..:.:|..|.|.||:|||:    ....
Human  1790 NVLADSVLMEQPPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVL 1854

  Fly  2325 DNLHVLQCSGSFDFGYEYMGLNGRLVITPLTDRIYLTITQALLMNLGGAPAGPAGTGKTETVKDL 2389
            ..|.:...:..|::|:||:|:..:||.||||||.|||:||||...|||:|.|||||||||:||.|
Human  1855 QQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKAL 1919

  Fly  2390 AKAMGLLCVVTNCGEGMDYRAVGTILSGLVQCGAWGCFDEFNRIDISVLSVISTQLQTIRNGLIR 2454
            ...:|...:|.||.|..|::|:|.|..||.|.|||||||||||::..:||.:|.|:|.|:..| |
Human  1920 GHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEAL-R 1983

  Fly  2455 KLDRFVFE-----------GVEIHLDPKCGVFVTMNPGYAGRTELPESVKALFRPVTCIKPDLEL 2508
            :.....::           ..::.:.|...:|:|||||||||:.||:::|.|||.:...|||.:|
Human  1984 EHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQL 2048

  Fly  2509 ICLISLFSDGFLTAKVLAKKMTVLYSLAQAQLSKQCHYDWGLRSLNSVLRMAGVMKRQ------- 2566
            |..:.|:|.||.||:|||.|:...:.|...|||.|.|||:|||:|.|||..||.:||:
Human  2049 IAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKR 2113

  Fly  2567 --------------SEDLPEAVVLMRVLRDMNFPKFVFEDVPLFLGLIKDLFPGIDCPRIGYPDF 2617
                          :|:|||..:|::.:.:...||.|.||:||...|:.|:|||:...|......
Human  2114 EKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTAL 2178

  Fly  2618 NAAVRHVLVNDGYILLPDQE-------DKVVQMYETMMTRHSTMLVGPTGGGKTVVINALVKAQT 2675
            ...::.| ..:.|:...|.|       :||:|:|:.....|..|:|||:|.||::....|:||..
Human  2179 REELKKV-CQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALE 2242

  Fly  2676 HM-GLPTKCLVLNPKACSVIELYGFLDMETRDWIDGLFSNIFREMNKPI--EREERRYACFDGDV 2737
            .: |:.....:::|||.|...|||.||..||:|.||||:::.|::...:  |.::|::..|||||
Human  2243 RLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWIVFDGDV 2307

  Fly  2738 DALWIENMNSVMDDNKLLTLANGERIRLENYCALLFEVGNLNYASPATVSRAGMVYVDPKNLRYS 2802
            |..|:||:|||:||||||||.||||:.|.....::|||.:|.||:.|||||.|||:.....|...
Human  2308 DPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTD 2372

  Fly  2803 PFWQRWVLT---------RPEPQRE------------------------LLNDFFEK--IITQSI 2832
            ..:..::..         ..|.||.                        ::..:|..  ::|:::
Human  2373 MIFNNFLARLRSIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKAL 2437

  Fly  2833 --AFILEGLDGTTQGNPLKLVIMQTDLNMVTQFCN---LYDALLPNYVMDSKNYDEPVQQNYNTD 2892
              ||.||.:...|     :|..:.:..:|:.|.|.   .|:|..|::.|..:..:..:|:
Human  2438 EHAFQLEHIMDLT-----RLRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQR----- 2492

  Fly  2893 SLECCFLQAVYGSMGACLVEKHQPVFDEYMKRISGFPLVQDTPENPASGGQFPQSKPTLYDYFWD 2957
                ..:.|:..|:......|.:....||::||:..|| ...|..|            :.||...
Human  2493 ----YLVYAILWSLSGDSRLKMRAELGEYIRRITTVPL-PTAPNIP------------IIDYEVS 2540

  Fly  2958 VKDNVWKAWEWVV---QPYTHDPQVKFSEILVPTVDNTRTNRTLSLMSEIKRPVLLVGEAGTSKT 3019
            :... |..|:..|   :..||  :|...:::|||:|..|....|.......:|::|.|..|:.||
Human  2541 ISGE-WSPWQAKVPQIEVETH--KVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKT 2602

  Fly  3020 ATIMQYLRNLNPSVNVILNINFSSRTSSLDVQHTLEAAVE-KRTKD--TYGP-PMGKRIACFIDD 3080
            .|:...||.| |.:.|: .:||||.|:...:..|.:...| :||.:  ...| .:||.:..|.|:
Human  2603 MTLFSALRAL-PDMEVV-GLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDE 2665

  Fly  3081 MNMPQVDDYGTQQPIALLKLFFERGGMYDRDKDLNWKKFKDLTFYAAMG-TAGGGRNEVDPRFIS 3144
            :|:|.:|.||||:.|:.::...|.||.| |..|..|.|.:.:.|..|.. ....||..:..||:.
Human  2666 INLPDMDKYGTQRVISFIRQMVEHGGFY-RTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLR 2729

  Fly  3145 MFSTYNIIFPNDESLIQIYSSIFKGHMVFVKFQPEYMLIADMIVHMTLKLFKM----VIVDLPPT 3205
            ......:.:|...||.|||.:.   :...::..|.....|:.:....::.:.|    ...|..|
Human  2730 HVPVVYVDYPGPASLTQIYGTF---NRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQP- 2790

  Fly  3206 PSKFHYIFNLKDLSR----IFAGMLLIEPTCFKGLRDLIRVWRNEYTRIICDRLITDNDIANVRR 3266
                |||::.::::|    ||..:..:|....:|   |||:|.:|..|:..|||:.|.:......
Human  2791 ----HYIYSPREMTRWVRGIFEALRPLETLPVEG---LIRIWAHEALRLFQDRLVEDEERRWTDE 2848

  Fly  3267 NLAVEVAERFPPTFEEEHGFIDAAAAEAEAQAR-LLYEP--SKADIDGGEEEGEEEEEGEEAPQV 3328
            |:.....:.||....|            :|.:| :||..  ||..|...:||
Human  2849 NIDTVALKHFPNIDRE------------KAMSRPILYSNWLSKDYIPVDQEE------------- 2888

  Fly  3329 ILSLKDYVLRDPLLFGDFRNFTNESEPRLYEDLLDYNSVYFLFTEILEEYCERKQKMTLVLFEDC 3393
               |:|||.....:|              ||:.||                     :.||||.:.
Human  2889 ---LRDYVKARLKVF--------------YEEELD---------------------VPLVLFNEV 2915

  Fly  3394 LEHLTRVHRTLRMNRGHVLLIGVGGSGKKCITRLAAFAAECDVFEITISRGYNEAAFREDLKVLY 3458
            |:|:.|:.|..|..:||:|||||.|:||..::|..|:.....|::|.:.|.|....|.|||:.:.
Human  2916 LDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVL 2980

  Fly  3459 TIAGVKRKKVVFLFTGAQVAEEGFLELINNILTVGQVPALFPDEDKDGIVNQVRKFAEEDGVSA- 3522
            ..:|.|.:|:.|:...:.|.:.||||.:|.:|..|:||.||..::...::.|.::.|:::|:..
Human  2981 RRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLD 3045

  Fly  3523 SKDAVWGYFLRTCAENLHVVLCMSPAGDALRNRCRNFPGLIGSTYIDWVFPWPRQALYAVAKLFL 3587
            |.:.::.:|......|||||..|:|:.:.|::|....|.|.....::|...|..:|||.|.|.|.
Human  3046 SHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFT 3110

  Fly  3588 TEHRL-------------------IPASHREAIVEHVVHVHTSIQQYSKDYLAKLRRNNFVTPKH 3633
            ::..|                   .|.|||||||...|.||.::.|.:.....:..|...:||:|
Human  3111 SKMDLEKPNYIVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRH 3175

  Fly  3634 YLDYINTYRGLLEEKAKFITQQRSRLGEGIKKIEEASVQIDELRIIVTEQKKNVAVASEECEAML 3698
            |||:||.|..|..||...:.:|:..|..|::||:|...|::|||       :::.:.|:|.|...
Human  3176 YLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELR-------RDLRIKSQELEVKN 3233

  Fly  3699 VTIESSTQKANVKKAEASEKSV---EVE---------IKGKQIAIEKDEAEEILAEAMPALEEAR 3751
            .......:|....:.||.:|.|   |::         |..||:::::|     |.:..||:.||:
Human  3234 AAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKED-----LDKVEPAVIEAQ 3293

  Fly  3752 LALSQLEKAQITEIRSFATPPAAVQVVCECVAILKGYKEINWKSAKGMMSDVNFLKSLMEMDCEA 3816
            .|:..::|..:.|:||.|.|||||::..|.:.:|.|....:||..:.::...||:.:::....|.
Human  3294 NAVKSIKKQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEE 3358

  Fly  3817 LTQKQITQCRQHMKTG-------NLEDMAKISVAGAGLLRFVRAVLGFFDVYKEVKPKKERLDFL 3874
            ::.    ..|:.||..       |.|.:.:.|:|...::::..|.|.:.|:.|.|:|.:..|..|
Human  3359 ISD----AIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKL 3419

  Fly  3875 VEEQEVQIKLLNHLNGEIQKLEEKLNELNENYATSMKQMRALTEMMQQAERRLIASDKLISGLTS 3939
            .::.:...:..|.:...|:.||..:....|.||..:.:.:|:...:...|.::..|..|:..|::
Human  3420 EDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSA 3484

  Fly  3940 ELIRWSKEMASLGQQLIDSVGGCLISASFLAYTGAFTWEFRKAMVFDDWLEDIASLGIPIQLPFK 4004
            |..||.|...:...|:....|.||:||:|:||.|.|..:.|:.: |..|...:....|..:....
Human  3485 ERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNL-FTTWSHHLQQANIQFRTDIA 3548

  Fly  4005 IDGYLTTDVEISQWSNEGLPPDELSIQNGILTMRASRFPLCIDPQLQALQWIRKREFKNNLKVLS 4069
            ...||:...|..:|....||.|:|..:|.|:..|.:|:||.|||..||.::|........:...|
Human  3549 RTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTS 3613

  Fly  4070 FSDSDFLKQLEMAIMYGTPVLFEDVDDYIDPVIDDILQKNIRIQGGRKFVMLGDKEVDWDPSFRV 4134
            |.|..|.|.||.|:.:|.|:|.:||:.| |||::.:|.:.:|..|||..:.|||:::|..|||.:
Human  3614 FLDDAFRKNLESALRFGNPLLVQDVESY-DPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVI 3677

  Fly  4135 YLTTKFSNPKFDPAVYAKALVINYTVTQTGLEDQLLSVVVGTERPDLEAQRESLIAQTSENKQLL 4199
            :|:|:....:|.|.:.::...:|:|||::.|:.|.|:.|:..||||::.:|..|:....|.:..|
Human  3678 FLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRL 3742

  Fly  4200 QQLEDSLLRELSTSTGNMLDNVELIETLENTKTKAGVVMEQLKLAADTAADIEVLRNGYRPAAKR 4264
            :|||.|||:.|:...|.:||:..:|.||||.|.:|..|..:::.......::|.:...|.|.:..
Human  3743 RQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTA 3807

  Fly  4265 GAVLFFALSDMATVNSMYQYALAAYLDVFVYSL-----RKAVPDASLNKRLNNIIKTLTENVYCY 4324
            .:.::|.:..:..::.:|||:|..:||::...|     .|.|.|.:  :||:.|.|.|.:..:..
Human  3808 CSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVLYENPNLKGVTDHT--QRLSIITKDLFQVAFNR 3870

  Fly  4325 GCTGIFERHKLLFSFQIA-TKLAQRDG-ILLQSELDFFIKGSIALTKSERSNPCKWLSEKSWEDV 4387
            ...|:..:..:.|:..:| .||....| ....:|...|::|:..:..:..:...:.|:.:..|.|
Human  3871 VARGMLHQDHITFAMLLARIKLKGTVGEPTYDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAV 3935

  Fly  4388 LKLAF--DFPDIFGTL--PDHFGRYLTEWKEWFDLENPEE-VPCPGDYNIKC----NAFQKLMFL 4443
            ::|:.  .|.|:...:  .:.||       .|.|..:||: ||.........    .|..:|:.:
Human  3936 VRLSCLPAFKDLIAKVQADEQFG-------IWLDSSSPEQTVPYLWSEETPATPIGQAIHRLLLI 3993

  Fly  4444 RCFRVDRIFRSINQYIVETMDEFYIMPPVVSFSAIYEQ-----------TSSTIPVCFVLSAGSD 4497
            :.||.||:....:.::...:.|        ||.:|.||           .....||......|.|
Human  3994 QAFRPDRLLAMAHMFVSTNLGE--------SFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYD 4050

  Fly  4498 PTNDLIKLADTIVGMSNFCHISLGQGQE-KAALRLLDGAIKQGMWLMLQNGHLLIRFVRELEKHL 4561
            .:..:..||  ....:....|::|..:. ..|.:.::.|:|.|.|:||:|.||...::.:|||.|
Human  4051 ASGHVEDLA--AEQNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKL 4113

  Fly  4562 DRIENPHPDFRLWITTDPTPTFPIGILQKSLKVVTEPPNGLKLNLRSTYFKVRQERLESCSHVAF 4626
            ..:: ||..|||::|.:..|..|:.:|:.....|.|||.|:|.|:..|:..:...|:....:...
Human  4114 HSLQ-PHACFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERA 4177

  Fly  4627 RPLVYVLAFFHAVVQERRKYDKLGWNIAYDFNDTDFDVCTEILRTYLTRCGTG-------KIPWN 4684
            | |.::||:|||::|||.:|..|||:..|:|.::|.....:.:.|:|.....|       ||||:
Human  4178 R-LYFLLAWFHAIIQERLRYAPLGWSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWS 4241

  Fly  4685 SLKYLIGEVMYGGRVIDDFDRRITNCYMNEYMGDFLFD-EFKVFHFYEDDNVDYCLPEEETILKE 4748
            :||.|:.:.:|||||.::||:|:.|.::........|| |||: ....|.:.|..:|  :.|.:|
Human  4242 ALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKL-ACKVDGHKDIQMP--DGIRRE 4303

  Fly  4749 DYIAHIDKLPLVNKPDVFGLHPNAEIGYYTMAARNIWNSLIELQ----------PQTGEGTGGIS 4803
            :::..::.||....|...||..|||....|....::.:.::::|          .:|.:.|...|
Human  4304 EFVQWVELLPDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDS 4368

  Fly  4804 RDD-------FIDSVAAGILKKLP---------------PAFETWRIRKQIQMSLSPTGVVLLQE 4846
            ..|       .:.:.|:..|..:|               |.|..:  .::::|     |..|||:
Human  4369 TSDGRPAWMRTLHTTASNWLHLIPQTLSHLKRTVENIKDPLFRFF--EREVKM-----GAKLLQD 4426

  Fly  4847 LDRFNLLVVRIKKTLELLRKAIAGEIGMDNVLDNIANSLFNGLLPAAWSKLAPATCKQLASWLEH 4911
                      :::.|..:.:...|:....|.|..:.|.|..|:||.:||.........:..|:..
Human  4427 ----------VRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSD 4481

  Fly  4912 LRLRAVQYKYWTLSG--------EPLVMWLSGLHIPQSYLTALVQIACRRNAWPLDRSTLFTYVT 4968
            ...|..|.:..:|:.        :.:.:.|.||.:|::|:||..|...:.|:|.|:...|...||
Human  4482 FSERIKQLQNISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVT 4546

  Fly  4969 KFADPDDVEERPVTGCL--VHGLYIEGGRFDLATNQLARSHPKVLVEELAILAVEPIEAHR-LKL 5030
                  ..:...:..|.  |.||.::|...:  .|:|:.|:        ||....|:...| :|.
Human  4547 ------TSQGATLDACSFGVTGLKLQGATCN--NNKLSLSN--------AISTALPLTQLRWVKQ 4595

  Fly  5031 QNT-YLAPVYTTSLRRNAMGVGLVF--EANLATSEDLSHWILQGVCL 5074
            .|| ..|.|.|..:..|.....|:|  :..:||.||...:..:||.:
Human  4596 TNTEKKASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAV 4642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc98D	NP_524541.3	DHC_N1	523..983	CDD:285571	109/543 (20%)
		DHC_N2	1798..2201	CDD:285579	121/420 (29%)
		P-loop_NTPase	2338..2565	CDD:304359	115/237 (49%)
		P-loop_NTPase	2654..2788	CDD:304359	64/136 (47%)
		P-loop_NTPase	2976..3246	CDD:304359	78/282 (28%)
		P-loop_NTPase	3378..3645	CDD:304359	92/286 (32%)
		MT	3658..3989	CDD:289543	90/349 (26%)
		AAA_9	4017..4233	CDD:289547	82/215 (38%)
		Dynein_heavy	4374..5068	CDD:281078	190/768 (25%)
DYNC1H1	NP_001367.2	Stem. /evidence=ECO:0000250	53..1867		434/2174 (20%)
		DHC_N1	242..832	CDD:400611	136/709 (19%)
		Interaction with DYNC1I2. /evidence=ECO:0000250	448..703		55/280 (20%)
		Interaction with DYNC1LI2. /evidence=ECO:0000250	651..802		35/178 (20%)
		DYN1	1046..4329	CDD:227570	995/3534 (28%)
		AAA 1. /evidence=ECO:0000250	1868..2099		113/231 (49%)
		AAA 2. /evidence=ECO:0000250	2180..2452		89/277 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2390..2411		3/20 (15%)
		AAA 3. /evidence=ECO:0000250	2556..2805		72/261 (28%)
		AAA 4. /evidence=ECO:0000250	2899..3168		87/303 (29%)
		Stalk. /evidence=ECO:0000250	3189..3500		80/326 (25%)
		AAA 5. /evidence=ECO:0000250	3553..3782		86/229 (38%)
		AAA 6. /evidence=ECO:0000250	4005..4221		63/227 (28%)
		Dynein_C	4333..4644	CDD:408026	72/343 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710