DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc98D and DNHD1

DIOPT Version :9

Sequence 1:	NP_524541.3	Gene:	Dhc98D / 43379	FlyBaseID:	FBgn0013813	Length:	5080	Species:	Drosophila melanogaster
Sequence 2:	NP_653267.2	Gene:	DNHD1 / 144132	HGNCID:	26532	Length:	4753	Species:	Homo sapiens

Alignment Length:	4786	Identity:	909/4786 - (18%)
Similarity:	1647/4786 - (34%)	Gaps:	1280/4786 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1026 MPVQSEAFSAYSVADSAGTEISSESENEGLLVGDTSQKKLMCRINRLTVLVAMIMWMVSNTRKAN 1090
            :||:.|:    |..|:|..|.....|....|..:..::|..                    :|::
Human   226 IPVRYES----SDTDNAEVEPVGRKETRSQLDYEVPREKAF--------------------QKSS 266

  Fly  1091 IQLQECTAFIKMVKDKKPKDVTAMDRHCVRTCEL-LQRAESQYLLPIWRELVGEKTLIEYDMDFV 1154
            ......|:|:    |.:......|:|:..:...| |..|.|:|..|             |.:..|
Human   267 TGFSPETSFL----DSQVMTALKMERYLKKIHFLYLNVAPSRYFRP-------------YSLMVV 314

  Fly  1155 ----VNLKRDVFD-------------------------VLFEAQQFEHLGFTLPAVLRTAI--MK 1188
                ||.:..:|.                         ||:  ||.:.:.|....:||.:.  .|
Human   315 PPDKVNPEHYIFSPFGILHVHPVEGSETMTLGTWHHHCVLW--QQLQFIPFFKYCLLRKSFTCWK 377

  Fly  1189 KDLLFKDYERMTEVVDRYRSIINNLSMSEVIFLRGHIYDTELFIQMGVGRYTWTSFNIGKFCDQI 1253
            |::..:...|:.:.::      |:|.::...|..|.::.:.|..::  ...:|....:.:..:.:
Human   378 KNVRLQGLHRLQKFLE------NHLLLAVPHFGAGLLHISRLLQEL--HSVSWLPQELDRCYELL 434

  Fly  1254 NSQLRKLTSIVSQIN-FIRLDLRSRIDMIKSFNLFNLDDELKVEDTSRSSGESYLQDRKNPSQRF 1317
            :.|    |::..:.: .:||       :.:..||......|..|||...  :..||:|.....|.
Human   435 DLQ----TALAEEKHKALRL-------LHRCLNLCTSILRLVHEDTYHM--QQCLQERVQNCDRI 486

  Fly  1318 KSVTGETITMFSVEKDVPADEKAEQA----CGSGIYP-------CQGYFELLE------------ 1359
            ::..|.........|.:  ::|.:||    ...|.:.       ||....:||
Human   487 RTGQGSIYLQRVQHKQL--EQKLKQAEAWWLQLGKFARLVDYMICQSLISVLEEQITSFVANILQ 549

  Fly  1360 ASRNRKAAQMKKLYDSLGPVL-VKLESLVLGTFSGRSDRMKTYYEYWEGETFKCIVDMTYQNLKC 1423
            |.|.:.....:.::|..|.:. |.....::.|.:|....:||          ..:..:...:||.
Human   550 APRQKPFLSSQLVFDDHGQLSHVPCVENMIQTLTGGLQSVKT----------SALQVVQSADLKT 604

  Fly  1424 YINRLLSNKPMFEVNA--VLLMSEIVLEPSVQELQNTIVTATKDYIS-----RLRIFTRWMTGTC 1481
            ..:.|.|.:...|.::  ..||.:...:||             |.:|     .:.:...|.:...
Human   605 SSDSLYSEEEDEEEDSKDEFLMPKFQGQPS-------------DAVSIFCGPNVGLVWPWKSHPI 656

  Fly  1482 I------ACPLVEMGKQFKYNYTYYEDVIQIRSIVDLVINIHD-LASRVANEARGFVSQFRKYFN 1539
            .      .|.|  .|:.|.:||...|:.:.....:...:||.. |...|..:.:.|..:......
Human   657 AGILEVRGCRL--RGQYFPHNYKQLEEDLDNNPKIQQALNIQQVLLEGVLCKVQEFCREHHWITG 719

  Fly  1540 LWAFEKSFICQKF-------LEKQVTLI-EIDEKFTFYSSIVETLANTRKFQDIKC--VRINLEP 1594
            ::.|.:|:..||.       ::..|||: .::......||:...|........:.|  |:..:|.
Human   720 IYEFLQSWGPQKLEDMRGGPIKNYVTLVSRLNVWQARVSSMPIELLTKGGLLLLSCHDVQAEMES 784

  Fly  1595 LLASITQ----HAQDWCTTLGEELLRHVNDNMRAMRNEVKTLSLNLNKTTRELEDFKLVMTTIGT 1655
            .|.||.:    |.|:.|..|.::|:                         .||.||..:..||.:
Human   785 KLNSIRKDILAHVQNECWNLSQQLM-------------------------TELTDFMHIFRTINS 824

  Fly  1656 VQSSTLTNEQKIHEMQETFTILSE--------------HKIMFPYED------------------ 1688
            ...:.....||::|..|.:..|.|              |..:|..|:
Human   825 DIHAIAQCTQKLNEANEQYVELEERMEYVRALHELIRNHFSLFSAENEALDISVRRQFGESPIPP 889

  Fly  1689 ------------MLMAHHLEKRWKRLFLSALYRYEKLQ----------PIKQKFADMTSVEIDEF 1731
                        .|:|..|...|:      .:::||.|          .|..|...:.:..:.|.
Human   890 CPPPPQPHLLHCPLLAPQLLDMWE------AFQFEKSQASEFLLSKRHAIMPKLQQLMAAALAEL 948

  Fly  1732 CDDLAEFIKDYDENGPGSVGAELERGVRLMDPYGQKIAERESRREELANAERLFDMAMVD----Y 1792
            ...||:.:     :||            .|||    ..::.|...:|.:.||.|...:.|    :
Human   949 EGLLAKAL-----SGP------------FMDP----TQDQRSTEHQLVSLERQFQNTVSDLSELH 992

  Fly  1793 HEFARVQTEFE--------------GLQQLYKLYKAQKYAREGWGKTLWADLDPNVLTEGVESYL 1843
            |.:| :.||.|              ..|:::.||:........|....:|...|.:..|..|.:|
Human   993 HAYA-IFTEDETPVPLPICGTRPIVQQQRIWHLYRVISENISEWKCMAFAKFSPAMAQEKTEGWL 1056

  Fly  1844 KEFRKFTKAVRTLPVGVQLEIH----------MKQFKGTVPLMVSLKHEALRERHWLQLMEKTGQ 1898
                  |:|.|   :...||:|          :.:|:..:||:..|.....:..:...|:...|.
Human  1057 ------TEAAR---MSTTLELHSPVLQHCMRILGEFRSYLPLLTKLGSLHPQSLNCQCLLRALGL 1112

  Fly  1899 YFDMSPARFTLENMFAMQLHKYQEIAEQILTNAIKELQIERGVQAVIETWASMAFKTFK------ 1957
            ....:....||..:....|.::.:...|:..|..:.:..:..::.:...|.:...:...
Human  1113 GSLQTIELLTLGQLLTYPLLEFADRINQVWQNENERIHAQETIRRLQRYWEARQLRLLNFILHVP 1177

  Fly  1958 -------------------HFKGSDDRGWVLGPVDEIMQILEDNAMNLQSMGASQFIGPFLETVN 2003
                               .....|...::|.....:...::::...|..:.|.:..|...:...
Human  1178 YEPPASERSKRQVLRSPQWEVVDKDSGTFILSDYSNLQDSIQESLQVLSKILAIEKSGDLNKIAL 1242

  Fly  2004 KWERTLALISEIIDEWLVVQRKWLYLEGIFIGGDIRTQLP--EEARKFDDIDKSYRRIMVDCAKN 2066
            :|...:..:..:::.||..|:||::|..:.  .:::.|.|  :...:|..:|..||.:|.....:
Human  1243 EWVAIMHGLGALLEVWLTFQQKWIFLNKVL--HEMKIQFPNADLNSRFKVMDDQYRTLMRISVAD 1305

  Fly  2067 PLVVPFCTVP---------GRLVE--IQGLGIGLENCQKSLNEYLDSKRRIFPRFYFISTDELLS 2120
            |:|:.. .||         |:.::  :|...:.||....||...|......|||.:|:|..||::
Human  1306 PMVLSL-VVPSAERSPYFQGQQLQQLLQAGSVELEGIIMSLESVLYGVCAHFPRLFFLSDSELVA 1369

  Fly  2121 ILGSS-EPSAVQNHIIKMYDNIK--SLRLVKEG------------SQTIVTGM--ISSEGEVMEF 2168
            :|.:. |....|..:.:.:.::.  |.|....|            :||.|..:  :.:.||.::.
Human  1370 LLAARLESCEAQLWVRRCFPHVHAVSFRSCPTGEKNTDDWESSPNTQTQVEALAVLGAGGEEVKL 1434

  Fly  2169 RHSARAAGRVEYW-----------------------------MNDVLDEMRRSNRFINKTAIYDF 2204
            :........:..|                             :.:.|.::.:.|:      :|
Human  1435 QGPLPLHPDLPKWLASLEKCLRLALVHMLQGCVAARLARGPSLGEALKQLPKQNK------LY-- 1491

  Fly  2205 GTDLQISRPDWL---MNYQGMVGLAASQVWWTAEVEEAFDQAQNHGNMRAMKDFLGKNNYQIEEL 2266
               ||:....|:   ..:.....|.|.:|.|.||:|||.   ...|.:..:...:.|
Human  1492 ---LQLYVQHWIDLVQAFPWQCVLVAEEVVWRAEMEEAL---LEWGTLAMVSMHMRK-------- 1542

  Fly  2267 VLKVRSNLSRNDRLK--------------FKAQCTVDVHARDIIDNFVRDNVLDASEFSWESQLR 2317
             |:|..|..|..|..              ..|...:.|..|||.....:..|.|.::|.|..||:
Human  1543 -LEVLVNFMRAQRASQGGQSLPSVRQTSLLSALLVMAVTHRDIAQLLEQHQVSDLTDFHWVRQLK 1606

  Fly  2318 FYWIKFYDNLHVLQCS--------------------------GSFDFGYEYMGLNGRLVITP--L 2354
            ::    ..:.|::..|                          .||.:.|||:|  .||...|  |
Human  1607 YH----LGSPHIIPKSPLQSLKTIASSEPSLSPAACWIDVLGRSFLYNYEYLG--PRLGPLPSLL 1665

  Fly  2355 TDRIYLTITQALLMNLGGAPAGPAGTGKTETVKDLAKAMGLLCVVTNCGEGMDYRAVGTILSGLV 2419
            .:|..|.:..||.....|...||.|.||...|..||:|:|...|:..|...::.:.:...|:|.:
Human  1666 PERPALVLLLALEEVACGTVLGPNGVGKRAIVNSLAQALGRQLVMLPCSPQIEAQCLSNYLNGAL 1730

  Fly  2420 QCGAWGCFDEFNRIDISVLSVISTQLQTIRNGLIRKLDRFVFEGVEIH---LDPK------CGVF 2475
            |.|||...::.:::...:||.:..:|     |.:..|...:::....:   :||.      ...|
Human  1731 QGGAWLLLEKVHQLPPGLLSALGQRL-----GELHHLYAPLYQEASRNTSTIDPTQPQLLGSSFF 1790

  Fly  2476 ----VTMNPGY-------AGRTELPESVKALFRPVTCIKPDLELICLISLFSDGFLTAKVLAKKM 2529
                |::..||       |..:.:|.::..|.|||....|||..:..::|...|...|..:|.::
Human  1791 EKHHVSVRLGYGCLLVLRALSSAVPANLHLLLRPVALALPDLRQVAELTLLGAGMRDAFQMATRL 1855

  Fly  2530 TVLYSLAQAQLS----------KQCHYDWGLRSLNSVLRMAGVMKRQSEDLPEAVVLMRVLRDMN 2584
            :..:||.:..:|          ||...| .:|:||.........|.:|....|...|:|
Human  1856 SKFFSLERELVSGPLPCRLPLLKQILED-TIRTLNVTKEEPKCQKPRSLAAIEEAALLR------ 1913

  Fly  2585 FPKFVFEDVPLF-----------LGLIKDLFPG---IDCPRIGYPDFNAAVRHVLVNDGYILLPD 2635
                    .|||           .||:..|||.   :....:.|......|...|...|....||
Human  1914 --------SPLFSILNGLHLHNLRGLLCALFPSASQVLAEPMTYKLMKPLVVEELQQVGLDPSPD 1970

  Fly  2636 QEDKVVQMYETMMTRHSTMLVGPTGGGKTVVINALVKAQTHMGL----------PTKCLVLNPKA 2690
            ....:.|:.:.:......:|:||.|.|||...::|.|.|..:..          |.:...|.|..
Human  1971 ILGSLEQLSQALSRASGILLLGPAGSGKTTCWHSLFKIQNRLAAMEDTSTQGCQPVEITHLYPSG 2035

  Fly  2691 CSVIELYGFLDMETRDWIDGLFSNIFR------EMNKPIEREE----RRYACFDGDVDALWIENM 2745
            .|..|..|:|  |...|..|:|..:.|      .|.:..:.||    :.:...||..:..|::::
Human  2036 LSPQEFLGWL--EGSCWHHGIFPKVLRAAGQCNNMGQKRQTEESIGIQHWIICDGASNGAWLDSI 2098

  Fly  2746 NSVMDDNKLLTLANGERIRLENYCALLFEVGNLNYASPATVSRAGMVYVDPKNLRYSPFWQ---- 2806
            ..::.:...|:|.:|::|.......||.||.:....||..|....:|:...:..     ||
Human  2099 TCLLSELPQLSLPSGQQIARPPGTFLLMEVADTTGISPTVVGCCALVWCGGEQT-----WQCILS 2158

  Fly  2807 RWVLTRPEPQR------ELLNDFFEKIITQSIAFI-LEGLDGTTQGNPLKLVIMQTDLNMVTQFC 2864
            ..:.:.|...|      ..||...|.::..::.|: .:|:....|.:..:.|.  ..:..||...
Human  2159 ALMASLPYEYRLQHRTVAELNHMAEVLVPATLRFLTCQGVSSLLQVHGQQAVC--AGVAEVTSMA 2221

  Fly  2865 NLYDALLPNYVM---------DSKNYDEPVQQNYNT--------------DSLECC--------- 2897
            .:..:||..::.         :..:|.:||.|::.:              |..:.|
Human  2222 RILHSLLDLHLRLKEEKAPGPEDLSYSDPVAQSFRSSKSSFLNRSQVDSDDVPDKCREHLLAVSS 2286

  Fly  2898 FLQAVYGSMGACLVEKHQPVFDEYMK----RISGFP------LVQDTPENPASG------GQFPQ 2946
            ||.|:....||.|..:..|:||.:::    |:|.:|      ||.|...:|..|      ||:..
Human  2287 FLFALIWGFGAHLPSRFWPIFDTFIRDSISRLSNYPEPPPSALVFDLHVSPEDGTLVPFTGQYLS 2351

  Fly  2947 S--KPTLYDYFWDVKDNVWKAWEWVVQPYTHDPQVKFSEILVPTVDNTRTNRTLSLMSEIKRPVL 3009
            |  |.||..:.                               |::...|....:.|:....:|||
Human  2352 SHIKGTLGTFH-------------------------------PSIQTERLLYVVDLLLSGGQPVL 2385

  Fly  3010 LVGEAGTSKTATIMQYLRNLNPSVNVILNINFSSRTSSLDVQHTLEAAVEKRTKDTYGPPMGKRI 3074
            |.|||.|.|:|.:...:...:|.:...::..|||....|.:...::...:...:..:.......:
Human  2386 LAGEAATGKSAFVEVLVEPHHPYIYSPIHPAFSSSHLRLLLSRGIQGQTQASPQPGHHQDSKPSL 2450

  Fly  3075 ACFIDDMNMPQVDDYGTQQPIALLKLFFERGGMYDRDKDLNWKKFK-DLTFYAAMGTAGGGRNEV 3138
            ...::|:::...|...:.||: |..|.....|.......|..:..: .:.|.|.:...|.....:
Human  2451 LFLLEDLHLATSDPEKSCQPV-LETLRQAMDGTVYAHSTLELQTLQPTVNFLATVTVPGYCERPL 2514

  Fly  3139 DPRFISMFSTYNIIFPNDESLIQIYSSIFKGHMVFVKFQPEYM-------LIADMIVHMTLKLFK 3196
            .||...:|:...:     ||:.|  :::.:.|:..::...|..       .:|..:|..:::.::
Human  2515 CPRLFRLFTVLAL-----ESMTQ--ATLLERHVPIIQAWLERFPSVERERALARGLVRASVEAWE 2572

  Fly  3197 MVIVDLPPTPSKFHYIFNLKDLSRIFAGMLL-------------------------IEPTC---F 3233
            .|.....|:|...||.|:|..:|.:.:.:.|                         :..||   .
Human  2573 AVCNCFMPSPLHPHYHFSLHSVSHLLSSLQLLPNRTGSRGFVDYPNHQEHLRRVSGLRGTCLTVM 2637

  Fly  3234 KGLRDLIRVWRNEYTRIICDRLITDNDIANVRRNLAVEVAERF-----PPTFEEEHGFIDAAAAE 3293
            ...|:::|:|.:|..|..||||.:..:.:...:.|.|.....|     |....::|    ..:.|
Human  2638 MATRNVVRLWLHEAQRTFCDRLDSPRERSYCAKLLLVVAQSVFCCGPGPQHLGKDH----QESEE 2698

  Fly  3294 AEAQARLLYEPSKA------DIDGGEEEGEEEEE------------------------------- 3321
            .|.:.|:....|:.      |......|.|||||
Human  2699 EEEEERVPEVESEGELAQWEDFSNSNSETEEEEEPYGLQVARVSNSRDPSLTPSIGPVSRGMKES 2763

  Fly  3322 ---------------------------GEEAPQV---------ILSL------KDYVLRDPLLFG 3344
                                       .::.||:         :|.|      .|.|....|:.|
Human  2764 ISHKIRQEKGTRASNYRLQVRRSFKTWWQKKPQMDLISPLLLPVLLLHPQEKPSDLVFSQELILG 2828

  Fly  3345 DFRNFTNESEPRLYEDLLDYNSVYFLFTEILEEY-----CERKQKMTLVLFEDCLEHLTRVHRTL 3404
                 .|...|.||.:..         .|.|||.     .:.|....|.......:|:.|:.|.|
Human  2829 -----PNSETPNLYLERQ---------WEKLEEQLATSAAQLKLSPHLARCHSMAQHVARLVRVL 2879

  Fly  3405 RMNRGH-VLLIGVGGSGKKCITRLAAFAAECDVFEITISRGYNEAAFREDLKVLYTIAGVKRKKV 3468
            ...|.| :||.|..|:|:.....||:...:...|.:...   :|.|..:.|:.....||:..:.|
Human  2880 ARPRQHGLLLSGALGTGRHTAITLASSICQAHFFHLPSG---SEEAILQCLRDASWHAGMLSQPV 2941

  Fly  3469 VFLF-TGAQVAEEGFLELINNILTVGQVPALFPDEDKDGIVNQVRKFAEEDGV--SASKDAVWGY 3530
            ..|. :|..:..   |..:..:.|.|..|..:.:.|.|.|...:.:  |..||  :..|:.|...
Human  2942 ALLVPSGVDLTT---LHRLLALATSGSFPGQYTEADLDRIGEHLPR--ENLGVKQNIKKEMVLQR 3001

  Fly  3531 FLRTCAENLHVVLCMSPAGDALRNRCRNFPGL-------IGSTYIDWVFPWPRQALYAVAKLFLT 3588
            |.:....:||:...:   ||  :...:..|..       :.:..||...||.:.||..||:..|.
Human  3002 FHQQVCSHLHLFFLI---GD--KQAHKQLPSTLFLRLLQLATASIDRYEPWDQAALAKVAQHHLE 3061

  Fly  3589 EHRLIPASHRE-----------AIVEHVVHVHTSIQQYSKDYLAKLRRNNFVTPKHYLDYINTYR 3642
            ..:.:|.....           ::.:.:..:|.|...|.:.....|   ..||||.:||:::|:
Human  3062 GAQSVPLDDGSWKYPDLQASIPSVAKAMALIHLSATHYHEHLCPAL---PLVTPKTFLDFLDTF- 3122

  Fly  3643 GLLEEKAKFITQQRSRLGEGIK-KIEEASVQIDELRIIVTEQKKNVAVASEECEAMLVTIESSTQ 3706
                    .:.||::.|  .|| |.:.....::.||:::.|...:.        .::..:|...:
Human  3123 --------LMLQQQTIL--KIKNKAQRVQNALENLRMLIKEHGTHA--------NLIFDLEQQLK 3169

  Fly  3707 KANVKKAEASEKSVEVEIKGKQIAIEKDEAEEILAE-------AMPALEEARL---------ALS 3755
            .:....:...::..:.::..|| .:|:...:|.|.|       |:.|..||.|         .||
Human  3170 DSGKSLSMFQQQLEQSKLLYKQ-QLEECRHQENLIENLARQRDALQAQREAFLEQMSKAFLEPLS 3233

  Fly  3756 QLEKAQITEIRSFATPPAAVQVVCECVAILKGYKEINWKSAKGMMSDVNFLKSLMEMDCEALTQK 3820
            ||:.|...||||:..||.:|..|.:.:..| .:.|..|.|||.::...:|.:.|:....|.:|..
Human  3234 QLQVADFEEIRSYRAPPESVVRVTDAMCDL-FHHETGWASAKQLLCTEDFYQELVFFPKEKITDS 3297

  Fly  3821 QITQCRQHMKTGNLEDMA--KISVAGAGLLRFVRAVLGFFDVYKEVKPKKERLDFLVEEQEVQIK 3883
            ::.:....:|...::|.|  .:|...|.|..::.|||.:...:....|    .|.|:::.|..:.
Human  3298 ELIKLHLILKAPGMDDAALRAVSRPAASLAAWLWAVLHYGLAHCRGLP----TDLLLQQVEATLT 3358

  Fly  3884 LLNHLNGEIQKLEEKLNELNENYATSMKQMRA----LTEMMQQAERRLIASDKLISGLTSELIRW 3944
            ......|..|...::..|.|...|..::..:|    :.:.:.||:........:.:.|.:.:..|
Human  3359 REQARLGYYQFQAQETLEHNLALAKMVEDAQASHNCVAKTLSQAQCGQYHKWPMKAALLTPMRAW 3423

  Fly  3945 SKEMASLGQQLIDSVGGCLISASFLAYTGAFTWEFRKAMVFDDWL------------EDIA---- 3993
            :.::..|..:.:...|..|:.::.:.|.|.|. ..|:..:.|:||            :|:|
Human  3424 TTQLQKLKGRCMTVFGDTLLCSAAIIYLGPFP-PLRRQELLDEWLALCRGFQEALGPDDVAQALK 3487

  Fly  3994 ----SLGIP-------IQLPFKIDGYLTTDVEISQWSNEGLPPDELSIQNGILTMR------ASR 4041
                |:.||       ...||.|...|:::.|..||.. .|.|...|.....|.:|      :.|
Human  3488 RKQKSVSIPPKNPLLATHSPFSILSLLSSESEQYQWDG-NLKPQAKSAHLAGLLLRSPTHYSSCR 3551

  Fly  4042 FPLCIDPQLQALQWI--------------------------RKREFKNNLK-------------- 4066
            :||.:||..:||.|:                          :|||.|.::|
Human  3552 WPLLLDPSNEALIWLDPLPLEENRSFAPALTEGRGKGLMRNQKRESKTDMKEEDDESEESNEAED 3616

  Fly  4067 -------------------------------------------------VLSFSDSDFLKQLEMA 4082
                                                             |||.:|.:...||:.|
Human  3617 QTKEQKAEERKNEQEKEQEENEEKEEEKTESQGSKPAYETQLPSLPYLSVLSGADPELGSQLQEA 3681

  Fly  4083 IMYGTPVLFEDVDDYIDPVIDDILQKNIRIQGGRKFVMLGDKEVDW------------DPSFRVY 4135
            ...|.|||..:|:                       :.||.:|:.|            .|.|.:|
Human  3682 AACGLPVLLTNVE-----------------------LGLGCEELQWLLQREQLSPPQVQPGFCLY 3723

  Fly  4136 LTTKFSNPKFDPAVYAKAL----VINYTVTQTGLEDQLLSVVVGTERPDLEAQRESLIAQTSENK 4196
            |:|..|....:..:..:.|    |::..:....||:|:|..::..|.|:||.:.:.|..:..:..
Human  3724 LSTTLSLCAMEKVLGCELLKGLNVLDLGLNMEILEEQMLHEILCREYPELETRWQDLKIRALDTC 3788

  Fly  4197 QLLQQLEDSL-----------------LRELSTSTGNMLDNVELIETLENTKTKAGVVMEQLKLA 4244
            :.::..|:.|                 ||.:..:.|.:.......|.||..|      ::::.|.
Human  3789 KAVEAAEERLLTMLLFQNPKRQKPAKFLRNIVRAQGKLCQLRAHCEELEGQK------LQEMVLW 3847

  Fly  4245 ADTAADIEVLRNGYRPAAKRGAVLFFALSDMATVNSMYQYALAAYLDVFVYSLRKAVP-----DA 4304
            |.           |||....|..:..|||.:..:..::..:...:|.|...:|....|     ..
Human  3848 AP-----------YRPVVWHGMAMVKALSQLQNLLPLFCMSPENWLAVTKQALDSMKPREINHGE 3901

  Fly  4305 SLNKRLNNIIKTLTENVYCYGCTGIFERHKLLFSFQIATKLAQRDGILLQSELDFFIKGSIALTK 4369
            .|...|..:...||..:.....|.:......|.....|..|.|..|...:.|......|..|...
Human  3902 DLASHLLQLRAHLTRQLLGSTVTALGLTQVPLVGALGALALLQATGKASELERLALWPGLAASPS 3966

  Fly  4370 SERSNPCK------WLSEKSWE--DVLKLAFDFPDIFGTLPDHFGRYLTEWKEWFDLENPEEVPC 4426
            :..|.|..      ||..|:|.  ::|:|...|..:..:|..|    .:.|:.:..|.:....|.
Human  3967 TVHSKPVSDVARPAWLGPKAWHECEMLELLPPFVGLCASLAGH----SSAWQAYLSLSSTVLGPA 4027

  Fly  4427 PGDYNIKCNAFQKLMFLRCFRVDRIFRSINQY----IVETMDEFYIMPPVVSFSAIYEQTSSTIP 4487
            ||......:..|||:..|..|.:.:..::..:    :...:||....|.:.     ::.:.:|.|
Human  4028 PGPGPEPLSLLQKLILWRVLRPECLAGALADFTTSLLGRPLDENTYAPTMP-----FKHSQATQP 4087

  Fly  4488 VCFVLSAGSDPTNDLIKLADTIV---------GMSNFCHISLGQ---GQEKAALRLLDGAIKQGM 4540
            :..:|.....|:..|..|  |::         |......|:||.   ......:..|..|:.:|.
Human  4088 MLILLPPPGHPSATLHPL--TVIQKLAAKYQQGQKQLQVIALGSEAWDPVSVVVSTLSQAMYEGH 4150

  Fly  4541 WLMLQNGHLLIRFVREL-------------------EKHLDR-----IENPHPDFRLW--ITTDP 4579
            ||:|.|.||:..:.:||                   |:.||:     :...|.|||||  :..:.
Human  4151 WLVLDNCHLMPHWPKELLQLLLELLGRAKVVADLESEQLLDQPESRNVSTVHRDFRLWLIVPAES 4215

  Fly  4580 TPTFPIGILQKSLKVVTEPPNGLKLNLRSTYFKVRQERLESCSHVAF-RPLVYV--LAFFHAVVQ 4641
            :.:.|..:.|.|:.|...  ..|:|.      .|..:.:|....|.: :|....  |...|.::.
Human  4216 SASLPAVLTQHSMPVFWN--QSLELG------HVLIDSVELAQQVLYMQPPTQALPLLLLHGLLL 4272

  Fly  4642 ERRKYDKLGWNIAYDFNDTDFDVCTEILRTYLTRCGTGKIPWNSLKYLIGEVMYGGRVIDDFDRR 4706
            .|:.|   |..:............|::|:|......:...|..:::.|...|.|||.:.|..||.
Human  4273 HRQLY---GTRLQAHRGRWSQVTLTQVLQTQDQLWASLSNPRAAMQELAASVFYGGPLGDTEDRE 4334

  Fly  4707 ----ITNCYMNEYMGDFL--------------FDEFKVFHFYEDDNVDYCLPEEETILKEDYIAH 4753
                :|...::...|.::              ..|.:     |.|.:..|.            |.
Human  4335 ALISLTQACLSPSSGSWVQPHTPQSLLATLMPLPELR-----ELDAMAECK------------AQ 4382

  Fly  4754 IDKLPLVNKPDVFGLHPNAEIGYYTMAARNIWNSLIELQ----PQTGEGTGGISRDDFIDSVAAG 4814
            :..||...:|.:.||....:.......:|.:.::|....    |::..|.....|
Human  4383 MHLLPSPPEPRLCGLSEGPQAWLLRRQSRALLSALQRSSPVWVPESRRGAQLAER---------- 4437

  Fly  4815 ILKKLPPAFETWRIRK---QIQMSLSP-----TGVVLLQELDR-FNLLVVRIKKTLELLRKAIAG 4870
                        |:|:   |:...|..     |.|:...|.|. :::|....::.||.:.:..|.
Human  4438 ------------RLRQRLVQVNRRLESLQDLLTHVIRQDESDAPWSVLGPNARRPLEGVLETEAL 4490

  Fly  4871 EIG---------MDNVLDN--------------IANSLFNGLLPAAWSKLAPATCKQLASWLEHL 4912
            |:.         :|.:|..              :|::|:.|.||..|...|||..:....||..|
Human  4491 ELSQLVGTLQRDLDCLLQQLKGAPPCPSRRCAAVAHALWTGRLPLPWRPHAPAGPQPPWHWLRQL 4555

  Fly  4913 RLRA-VQYKYWTLSGE------PLVMWLSGLHIPQSYLTAL 4946
            ..|. :..:|..:..:      ..|..||....|:..|.||
Human  4556 SRRGQLLVRYLGVGADASSDVPERVFHLSAFRHPRRLLLAL 4596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc98D	NP_524541.3	DHC_N1	523..983	CDD:285571
		DHC_N2	1798..2201	CDD:285579	81/510 (16%)
		P-loop_NTPase	2338..2565	CDD:304359	64/258 (25%)
		P-loop_NTPase	2654..2788	CDD:304359	39/153 (25%)
		P-loop_NTPase	2976..3246	CDD:304359	53/305 (17%)
		P-loop_NTPase	3378..3645	CDD:304359	63/293 (22%)
		MT	3658..3989	CDD:289543	73/353 (21%)
		AAA_9	4017..4233	CDD:289547	62/343 (18%)
		Dynein_heavy	4374..5068	CDD:281078	134/687 (20%)
DNHD1	NP_653267.2	DHC_N2	1019..1467	CDD:285579	76/459 (17%)
		P-loop_NTPase	1649..1867	CDD:304359	57/224 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2688..2766		12/81 (15%)
		P-loop_NTPase	2870..3119	CDD:304359	60/264 (23%)
		MT	<3193..3467	CDD:289543	63/279 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3580..3657		5/76 (7%)
		AAA_9	<3664..3802	CDD:289547	35/160 (22%)
		Dynein_heavy	3979..4741	CDD:281078	133/679 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4669..4697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810