DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc98D and Dync1h1

DIOPT Version :9

Sequence 1:	NP_524541.3	Gene:	Dhc98D / 43379	FlyBaseID:	FBgn0013813	Length:	5080	Species:	Drosophila melanogaster
Sequence 2:	NP_084514.2	Gene:	Dync1h1 / 13424	MGIID:	103147	Length:	4644	Species:	Mus musculus

Alignment Length:	5169	Identity:	1300/5169 - (25%)
Similarity:	2229/5169 - (43%)	Gaps:	957/5169 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 GGGAGGPAG------ETGEDIS---SEAKESGPGLLELSKPSEFRLRALKQQKKMKEK------- 378
            |||..|.||      :...|::   ...::..|.|||....:...|.|..::|...|:
Mouse     5 GGGEDGSAGLEVSAVQNVADVAVLQKHLRKLVPLLLEDGGDAPAALEAALEEKSALEQMRKFLSD 69

  Fly   379 ----EAAAKKAKAKKTDAEPTEEEEEADAHKV-----------------EAHLSSSEEEVEIKVE 422
                ....:::..|:...:..|||:|..::.:                 .|.:..:::.|..::.
Mouse    70 PQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIKRAPVIDADKPVSSQLR 134

  Fly   423 KLTIGQRWEKMLNETKAKVEAEHA-AEEATPPRITPIQR----------RLLKEIEEFQSEITWT 476
            .||:.:         .:..|..|: ...|..|......|          ::...:|:..:|:...
Mouse   135 VLTLSE---------DSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAPSVEKKIAELEMG 190

  Fly   477 INHI-----VWAFSLPSSYILPG-----------QEATEFEDAIIRVPVDPKRLDLVITYTQQQL 525
            :.|:     :...|||...|:..           .:.|:|.|.:    .||..|:        ||
Mouse   191 LLHLQQNIEIPEISLPIHPIITNVAKQCYERGEKPKVTDFGDKV----EDPTFLN--------QL 243

  Fly   526 EEVVDGWIKYLKKTMKTLTDAKLDDFTPMAEHRYWHKMEVELYGTLEQLKTEFVVAVLQRLTDDK 590
            :..|:.||:.::|..|  .|......|.:.|..:|..:|..||...|:.::..|:..|..|...|
Mouse   244 QSGVNRWIREIQKVTK--LDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHGK 306

  Fly   591 SPVLDEWQAVVE-KTEARFKLAKEN-SDYLGTIIDY----------LEKVRSYESFKMVVL---- 639
                 .:.|.|. .|:...|.|.|. :||...:.|:          |:|:|.    .:|.:
Mouse   307 -----RFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQ----ALVAIFTHL 362

  Fly   640 -QIPNIMVGLRHIWTMSSHYCRDPEMQVLLCQISNVFVQKVKSIINFENIFKYSATYTYETATNC 703
             :|.|....::....:.....||     |..|:..|...:....:.:|...|....        |
Mouse   363 RKIRNTKYPIQRALRLVEAISRD-----LSSQLLKVLGTRKLMHVAYEEFEKVMVA--------C 414

  Fly   704 ANLLRCWKQAYKLSRQHIEDSGAGSRWEFDRVALFNEVNHIHR-VAVDIAYVGRVFVQYENLFGH 767
            ..:.:.|...|:..:..:.|.....|.|  .:.:...:|..|| :...:..:.:...|:|.|
Mouse   415 FEVFQTWDDEYEKLQVLLRDIVKRKREE--NLKMVWRINPAHRKLQARLDQMRKFRRQHEQL--- 474

  Fly   768 RLKACIADPSIVDNLMR--------------------KVYRMLDDL---------------IKSV 797
                    .:::..::|                    ||..:|.|.               :|.|
Mouse   475 --------RAVIVRVLRPQVTAVAQQNQGEAPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEV 531

  Fly   798 D-YDMFRPGNWENWEYSLELFNKRLDNVENEAKNVIDQSINSLLSSEKGLDLVVNAM-NIDTRAT 860
            | .|:.:.|. |.||.:::.:::|:|.||..        |.:.|..:.|.....|.| .|.:|..
Mouse   532 DGLDVSKEGT-EAWEAAMKRYDERIDRVETR--------ITARLRDQLGTAKNANEMFRIFSRFN 587

  Fly   861 LQEFVATKHENLLRFFVTEI-----NAVERVFTKLKKSPPMAKHQPAKIS----------AIFWA 910
            .. ||.......:|.:.|::     :.:|.:..|.|...|.:  |..|:|          :|.||
Mouse   588 AL-FVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQYPQS--QACKMSHVRDLPPVSGSIIWA 649

  Fly   911 RLLGKKLKTSVLAFKRVED------EPAIKNSFLKR--SSFKQYFELMTVMFQF-EKVLFENF-I 965
            :.:.::|...:   |||||      |..::...||:  .||:.......:...: .||...|. :
Mouse   650 KQIDRQLTAYM---KRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGV 711

  Fly   966 QNATYLVNTT----NRSNVLRIRICKESTMSYISEAVQTLK-AKPRPELQMTSDRRVTPVKSSNL 1025
            ....:.:.:.    ...|||::::.....:..:|:.|:.|| ...|..|.:.:...    :::.|
Mouse   712 SGRIFTIESARVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAH----QANQL 772

  Fly  1026 MPVQSEAFSAYSVADSAGT-EISSESENEGLLVGDTSQKKLMCRINRLTVLVAMIMWMVSNTRKA 1089
            .|.      |.|:.:|..| |.:.|...|.               |.:::|||.:        |.
Mouse   773 YPF------AISLIESVRTYERTCEKVEER---------------NTISLLVAGL--------KK 808

  Fly  1090 NIQ--LQECTAFIKMVKDKKPKDVTAMDRHCVRTCELLQRAESQYLLPIWRELVGEKTLIEYDMD 1152
            .:|  :.|..|.:                           .||..|.|..:.|.          :
Mouse   809 EVQALIAEGIALV---------------------------WESYKLDPYVQRLA----------E 836

  Fly  1153 FVVNLKRDVFDVLFEAQQFEHLGFTLPAVLRTAIMKKDLLFKDYERMTEVVDRYRSIINNLSMSE 1217
            .|.|.:..|.|:|...::.:           ..:...:....|::..:|:::|.:..:::|::
Mouse   837 TVFNFQEKVDDLLIIEEKID-----------LEVRSLETCMYDHKTFSEILNRVQKAVDDLNL-- 888

  Fly  1218 VIFLRGHIY----------DTE----LFIQMGVGRYTWTSFNIGKFCDQINSQLRKLTSIVSQIN 1268
                  |.|          |.|    |.:::..|...||...:|:..|
Mouse   889 ------HSYSNLPIWVNKLDMEIERILGVRLQAGLRAWTQVLLGQAED----------------- 930

  Fly  1269 FIRLDLRSRIDMIKSFNLFNLDDELKVEDTSRSSGESYLQDRKNPSQRFKSVTGE-TITMFSVEK 1332
                  ::.:||          |....:.:.:..||          .:.|:|..| .||...:..
Mouse   931 ------KAEVDM----------DTDAPQVSHKPGGE----------PKIKNVVHELRITNQVIYL 969

  Fly  1333 DVPADEKAEQACGSGIYPCQGYFELLEASRNRKAAQMKKLYDSLGPVLVKLESLVLGTFSGRSDR 1397
            :.|.:|            |:                 .|||..:  ...|:..|.|.....:..:
Mouse   970 NPPIEE------------CR-----------------YKLYQEM--FAWKMVVLSLPRIQSQRYQ 1003

  Fly  1398 MKTYYEYWEGETFKCIVDMTYQNLKCYINRLLSNKPMFEVNAVLLMSEIVLEPSVQELQNTIVTA 1462
            :..:||..|.|.|       |:|       .|:..|         ...:.||.|...:.. |||.
Mouse  1004 VGVHYELTEEEKF-------YRN-------ALTRMP---------DGPVALEESYSAVMG-IVTE 1044

  Fly  1463 TKDYISRLRIFTRWMTGTCIACPLVEMGKQFKYNYTYYEDVIQIRSIVDLVINIHDLASRVANEA 1527
            .:.|:.      .|:...|    |.:|..:..||                         |:..:
Mouse  1045 VEQYVK------VWLQYQC----LWDMQAENIYN-------------------------RLGED- 1073

  Fly  1528 RGFVSQFRKYFNLWAFEKSFICQKFLEKQVTLIEIDE-KFTFYSSIVETLANTRKFQDIKCVRIN 1591
                      .|.|              |..|::|.: :.||.:      |.|:|  :...|.|:
Mouse  1074 ----------LNKW--------------QALLVQIRKARGTFDN------AETKK--EFGPVVID 1106

  Fly  1592 LEPLLASITQHAQDWCTTLGEELLRHVNDNMRAMRNEVKTLSLNLNKTTRELEDFKL-------V 1649
            ...:.:.:......|...:..:..:.:..||....:::       :|:.:|||...:       .
Mouse  1107 YGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQI-------SKSRQELEQHSVDTASTSDA 1164

  Fly  1650 MTTIGTVQSSTLTNEQKIHEMQETF-------TILSEHKIMFPYEDMLMAHHLEKRWKRLFLSAL 1707
            :|.|..|||.    ::||.:.::..       .:|.:.:..|| ...|...::|..| ..|...:
Mouse  1165 VTFITYVQSL----KRKIKQFEKQVELYRNGQRLLEKQRFQFP-PSWLYIDNIEGEW-GAFNDIM 1223

  Fly  1708 YRYEKLQPIKQKFAD--MTSVEIDEFCDD-LAEFIKDYDENGPGSVGAELERGVRLMDPYGQKIA 1769
            .|  |...|:|:.|:  |..|:.|...:. ..:.:.|:::..|.:.....|..::.:..|..|..
Mouse  1224 RR--KDSAIQQQVANLQMKIVQEDRAVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFG 1286

  Fly  1770 ERESRREELANAE---RLFDMAMVDYHEFARVQTEFEGLQ-------QLYKLYKAQKYAREGWGK 1824
            ..:..||:.|.|:   .|.|..::...| .|||...|.||       :|.|:::.....:|
Mouse  1287 RLKDDREKCAKAKEALELTDTGLLSGSE-ERVQVALEELQDLKGVWSELSKVWEQIDQMKE---- 1346

  Fly  1825 TLWADLDPNVLTEGVESYLKEFRKFTKAVRTLPVGVQLEIHMKQFKGTVP---LMVSLKHEALRE 1886
            ..|..:.|..|.:.::..|.:.:.|...:|..   ...|...:..||.:.   |::.||.|||::
Mouse  1347 QPWVSVQPRKLRQNLDGLLNQLKNFPARLRQY---ASYEFVQRLLKGYMKINMLVIELKSEALKD 1408

  Fly  1887 RHWLQLMEKTGQYFDMSPARFTLENMFAMQLHKYQEIAEQILTNAIKELQIERGVQAVIETWASM 1951
            |||.|||::.  :.:...:..||..::.:.|.|.:.:.:.:|..|..|:.:|..::.:.|.|.:.
Mouse  1409 RHWKQLMKRL--HVNWVVSELTLGQIWDVDLQKNEAVVKDVLLVAQGEMALEEFLKQIREVWNTY 1471

  Fly  1952 AFKTFKH-FKGSDDRGWVLGPVDEIMQILEDNAMNLQSMGASQFIGPFLETVNKWERTLALISEI 2015
            ......: .|....|||     |::...::::..::.:|..|.:...|.|....||..|..|..:
Mouse  1472 ELDLVNYQNKCRLIRGW-----DDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMAL 1531

  Fly  2016 IDEWLVVQRKWLYLEGIFIG-GDIRTQLPEEARKFDDIDKSYRRIMVDCAKNPLVVPFCTVPGRL 2079
            .|.|:.|||:|:||||||.| .||:..||.|.::|..|...:..:|...:|:|||:....:.|..
Mouse  1532 FDVWIDVQRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQ 1596

  Fly  2080 VEIQGLGIGLENCQKSLNEYLDSKRRIFPRFYFISTDELLSILGSSEPSA-VQNHIIKMYDNIKS 2143
            ..::.|...|...||:|.|||:.:|..||||||:..::||.|:|:|:..| :|.|..||:..:.|
Mouse  1597 RSLERLADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSS 1661

  Fly  2144 LRLVKEGSQTIVTGMISSEGEVMEFRH--SARAAGRVEYWMNDVLDEMRRSNRFI---NKTAIYD 2203
            :.|.::.|  :|.|:.|.|||.:.|:.  |.....::..|:..|..|||.:...:   :.|.:..
Mouse  1662 IILNEDNS--VVLGISSREGEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEI 1724

  Fly  2204 FGTDLQISRPD----WLMNYQGMVGLAASQVWWTAEVEEAFDQAQNHGNMRAMKDFLGKNNYQIE 2264
            ||....|. |:    |:..||..:.:.::|:.|:..||.|.......|::..::..|......:.
Mouse  1725 FGKATSID-PNTYITWIDKYQAQLVVLSAQIAWSENVENALSNVGGGGDVGPLQSVLSNVEVTLN 1788

  Fly  2265 ELVLKVRSNLSRNDRLKFKAQCTVDVHARDIIDNFVRDNVLDASEFSWESQLRFYW----IKFYD 2325
            .|...|........|.|.:...|..||.||:..:.::..:.:|..|.|.||:|||:    .....
Mouse  1789 VLADSVLMEQPPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQ 1853

  Fly  2326 NLHVLQCSGSFDFGYEYMGLNGRLVITPLTDRIYLTITQALLMNLGGAPAGPAGTGKTETVKDLA 2390
            .|.:...:..|::|:||:|:..:||.||||||.|||:||||...|||:|.|||||||||:||.|.
Mouse  1854 QLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG 1918

  Fly  2391 KAMGLLCVVTNCGEGMDYRAVGTILSGLVQCGAWGCFDEFNRIDISVLSVISTQLQTIRNGLIRK 2455
            ..:|...:|.||.|..|::|:|.|..||.|.|||||||||||::..:||.:|.|:|.|:..| |:
Mouse  1919 HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEAL-RE 1982

  Fly  2456 LDRFVFE-----------GVEIHLDPKCGVFVTMNPGYAGRTELPESVKALFRPVTCIKPDLELI 2509
            .....::           ..::.:.|...:|:|||||||||:.||:::|.|||.:...|||.:||
Mouse  1983 HSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLI 2047

  Fly  2510 CLISLFSDGFLTAKVLAKKMTVLYSLAQAQLSKQCHYDWGLRSLNSVLRMAGVMKRQ-------- 2566
            ..:.|:|.||.||:|||.|:...:.|...|||.|.|||:|||:|.|||..||.:||:
Mouse  2048 AQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKRE 2112

  Fly  2567 -------------SEDLPEAVVLMRVLRDMNFPKFVFEDVPLFLGLIKDLFPGIDCPRIGYPDFN 2618
                         :|:|||..:|::.:.:...||.|.||:||...|:.|:|||:...|.......
Mouse  2113 KEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALR 2177

  Fly  2619 AAVRHVLVNDGYILLPDQE-------DKVVQMYETMMTRHSTMLVGPTGGGKTVVINALVKAQTH 2676
            ..::.| ..:.|:...|.|       :||:|:|:.....|..|:|||:|.||::....|:||...
Mouse  2178 EELKKV-CQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALER 2241

  Fly  2677 M-GLPTKCLVLNPKACSVIELYGFLDMETRDWIDGLFSNIFREM--NKPIEREERRYACFDGDVD 2738
            : |:.....:::|||.|...|||.||..||:|.||||:::.|::  |...|.::|::..||||||
Mouse  2242 LEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDNVRGELQKRQWIVFDGDVD 2306

  Fly  2739 ALWIENMNSVMDDNKLLTLANGERIRLENYCALLFEVGNLNYASPATVSRAGMVYVDPKNLRYSP 2803
            ..|:||:|||:||||||||.||||:.|.....::|||.:|.||:.|||||.|||:.....|....
Mouse  2307 PEWVENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDM 2371

  Fly  2804 FWQRWVLT---------RPEPQRE------------------------LLNDFFEK--IITQSI- 2832
            .:..::..         ..|.||.                        ::..:|..  ::|:::
Mouse  2372 IFNNFLARLRSIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALE 2436

  Fly  2833 -AFILEGLDGTTQGNPLKLVIMQTDLNMVTQFCN---LYDALLPNYVMDSKNYDEPVQQNYNTDS 2893
             ||.||.:...|     :|..:.:..:|:.|.|.   .|:|..|::.|..:..:..:|:
Mouse  2437 HAFKLEHIMDLT-----RLRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQR------ 2490

  Fly  2894 LECCFLQAVYGSMGACLVEKHQPVFDEYMKRISGFPLVQDTPENPASGGQFPQSKPTLYDYFWDV 2958
               ..:.|:..|:......|.:....||::||:..|| ...|..|            :.||...:
Mouse  2491 ---YLVYAILWSLSGDSRLKMRAELGEYIRRITTVPL-PTAPNVP------------IIDYEVSI 2539

  Fly  2959 KDNVWKAWEWVV---QPYTHDPQVKFSEILVPTVDNTRTNRTLSLMSEIKRPVLLVGEAGTSKTA 3020
            ... |..|:..|   :..||  :|...:::|||:|..|....|.......:|::|.|..|:.||.
Mouse  2540 SGE-WSPWQAKVPQIEVETH--KVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTM 2601

  Fly  3021 TIMQYLRNLNPSVNVILNINFSSRTSSLDVQHTLEAAVE-KRTKD--TYGP-PMGKRIACFIDDM 3081
            |:...||.| |.:.|: .:||||.|:...:..|.:...| :||.:  ...| .:||.:..|.|::
Mouse  2602 TLFSALRAL-PDMEVV-GLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEI 2664

  Fly  3082 NMPQVDDYGTQQPIALLKLFFERGGMYDRDKDLNWKKFKDLTFYAAMG-TAGGGRNEVDPRFISM 3145
            |:|.:|.||||:.|:.::...|.||.| |..|..|.|.:.:.|..|.. ....||..:..||:..
Mouse  2665 NLPDMDKYGTQRVISFIRQMVEHGGFY-RTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRH 2728

  Fly  3146 FSTYNIIFPNDESLIQIYSSIFKGHMVFVKFQPEYMLIADMIVHMTLKLFKM----VIVDLPPTP 3206
            .....:.:|...||.|||.:.   :...::..|.....|:.:....::.:.|    ...|..|
Mouse  2729 VPVVYVDYPGPASLTQIYGTF---NRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQP-- 2788

  Fly  3207 SKFHYIFNLKDLSR----IFAGMLLIEPTCFKGLRDLIRVWRNEYTRIICDRLITDNDIANVRRN 3267
               |||::.::::|    ||..:..:|....:|   |||:|.:|..|:..|||:.|.:......|
Mouse  2789 ---HYIYSPREMTRWVRGIFEALRPLETLPVEG---LIRIWAHEALRLFQDRLVEDEERRWTDEN 2847

  Fly  3268 LAVEVAERFPPTFEEEHGFIDAAAAEAEAQAR-LLYEP--SKADIDGGEEEGEEEEEGEEAPQVI 3329
            :.:...:.||...:|            :|.:| :||..  ||..|...:||
Mouse  2848 IDMVALKHFPNIDKE------------KAMSRPILYSNWLSKDYIPVDQEE-------------- 2886

  Fly  3330 LSLKDYVLRDPLLFGDFRNFTNESEPRLYEDLLDYNSVYFLFTEILEEYCERKQKMTLVLFEDCL 3394
              |:|||.....:|              ||:.||                     :.||||.:.|
Mouse  2887 --LRDYVKARLKVF--------------YEEELD---------------------VPLVLFNEVL 2914

  Fly  3395 EHLTRVHRTLRMNRGHVLLIGVGGSGKKCITRLAAFAAECDVFEITISRGYNEAAFREDLKVLYT 3459
            :|:.|:.|..|..:||:|||||.|:||..::|..|:.....|::|.:.|.|....|.|||:.:..
Mouse  2915 DHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLR 2979

  Fly  3460 IAGVKRKKVVFLFTGAQVAEEGFLELINNILTVGQVPALFPDEDKDGIVNQVRKFAEEDGVSA-S 3523
            .:|.|.:|:.|:...:.|.:.||||.:|.:|..|:||.||..::...::.|.::.|:::|:.. |
Mouse  2980 RSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDS 3044

  Fly  3524 KDAVWGYFLRTCAENLHVVLCMSPAGDALRNRCRNFPGLIGSTYIDWVFPWPRQALYAVAKLFLT 3588
            .:.::.:|......|||||..|:|:.:.|::|....|.|.....::|...|..:|||.|.|.|.:
Mouse  3045 HEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTS 3109

  Fly  3589 EHRL-------------------IPASHREAIVEHVVHVHTSIQQYSKDYLAKLRRNNFVTPKHY 3634
            :..|                   .|.:||||||...|.||.::.|.:.....:..|...:||:||
Mouse  3110 KMDLEKPNYIVPDYMPVVYDKLPQPPTHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHY 3174

  Fly  3635 LDYINTYRGLLEEKAKFITQQRSRLGEGIKKIEEASVQIDELRIIVTEQKKNVAVASEECEAMLV 3699
            ||:||.|..|..||...:.:|:..|..|::||:|...|::|||       :::.:.|:|.|....
Mouse  3175 LDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELR-------RDLRIKSQELEVKNA 3232

  Fly  3700 TIESSTQKANVKKAEASEKSV---EVE---------IKGKQIAIEKDEAEEILAEAMPALEEARL 3752
            ......:|....:.||.:|.|   |::         |..||:::::|     |.:..||:.||:.
Mouse  3233 AANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKED-----LDKVEPAVIEAQN 3292

  Fly  3753 ALSQLEKAQITEIRSFATPPAAVQVVCECVAILKGYKEINWKSAKGMMSDVNFLKSLMEMDCEAL 3817
            |:..::|..:.|:||.|.|||||::..|.:.:|.|....:||..:.::...||:.:::....|.:
Mouse  3293 AVKSIKKQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEI 3357

  Fly  3818 TQKQITQCRQHMKTG-------NLEDMAKISVAGAGLLRFVRAVLGFFDVYKEVKPKKERLDFLV 3875
            :.    ..|:.||..       |.|.:.:.|:|...::::..|.|.:.|:.|.|:|.:..|..|.
Mouse  3358 SD----AIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE 3418

  Fly  3876 EEQEVQIKLLNHLNGEIQKLEEKLNELNENYATSMKQMRALTEMMQQAERRLIASDKLISGLTSE 3940
            ::.:...:..|.:...|:.||..:....|.||..:.:.:|:...:...|.::..|..|:..|::|
Mouse  3419 DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAE 3483

  Fly  3941 LIRWSKEMASLGQQLIDSVGGCLISASFLAYTGAFTWEFRKAMVFDDWLEDIASLGIPIQLPFKI 4005
            ..||.|...:...|:....|.||:||:|:||.|.|..:.|:.: |..|...:....|..:.....
Mouse  3484 RERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNL-FTTWSHHLQQANIQFRTDIAR 3547

  Fly  4006 DGYLTTDVEISQWSNEGLPPDELSIQNGILTMRASRFPLCIDPQLQALQWIRKREFKNNLKVLSF 4070
            ..||:...|..:|....||.|:|..:|.|:..|.:|:||.|||..||.::|........:...||
Mouse  3548 TEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSF 3612

  Fly  4071 SDSDFLKQLEMAIMYGTPVLFEDVDDYIDPVIDDILQKNIRIQGGRKFVMLGDKEVDWDPSFRVY 4135
            .|..|.|.||.|:.:|.|:|.:||:.| |||::.:|.:.:|..|||..:.|||:::|..|||.::
Mouse  3613 LDDAFRKNLESALRFGNPLLVQDVESY-DPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIF 3676

  Fly  4136 LTTKFSNPKFDPAVYAKALVINYTVTQTGLEDQLLSVVVGTERPDLEAQRESLIAQTSENKQLLQ 4200
            |:|:....:|.|.:.::...:|:|||::.|:.|.|:.|:..||||::.:|..|:....|.:..|:
Mouse  3677 LSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLR 3741

  Fly  4201 QLEDSLLRELSTSTGNMLDNVELIETLENTKTKAGVVMEQLKLAADTAADIEVLRNGYRPAAKRG 4265
            |||.|||:.|:...|.:||:..:|.||||.|.:|..|..:::.......::|.:...|.|.:...
Mouse  3742 QLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTAC 3806

  Fly  4266 AVLFFALSDMATVNSMYQYALAAYLDVF---VYSLRKAVPDASLNKRLNNIIKTLTENVYCYGCT 4327
            :.::|.:..:..|:.:|||:|..:||::   :|............:||:.|.|.|.:..:.....
Mouse  3807 SSIYFTMESLKQVHFLYQYSLQFFLDIYHNVLYENPNLKGATDHTQRLSIITKDLFQVAFNRVAR 3871

  Fly  4328 GIFERHKLLFSFQIA-TKLAQRDG-ILLQSELDFFIKGSIALTKSERSNPCKWLSEKSWEDVLKL 4390
            |:..:..:.|:..:| .||....| ....:|...|::|...:..:..:...:.|:.:..|.|::|
Mouse  3872 GMLHQDHITFAMLLARIKLKGTVGEPTYDAEFQHFLRGKEIVLSAGSTPKIQGLTVEQAEAVVRL 3936

  Fly  4391 AF--DFPDIFGTL--PDHFGRYLTEWKEWFDLENPEE-VPCPGDYNIKC----NAFQKLMFLRCF 4446
            :.  .|.|:...:  .:.||       .|.|..:||: ||.........    .|..:|:.::.|
Mouse  3937 SCLPAFKDLIAKVQADEQFG-------IWLDSSSPEQTVPYLWSEETPTTPIGQAIHRLLLIQAF 3994

  Fly  4447 RVDRIFRSINQYIVETMDEFYIMPPVVSFSAIYEQ-----------TSSTIPVCFVLSAGSDPTN 4500
            |.||:....:.::...:.|        ||.:|.||           .....||......|.|.:.
Mouse  3995 RPDRLLAMAHMFVSTNLGE--------SFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASG 4051

  Fly  4501 DLIKLADTIVGMSNFCHISLGQGQE-KAALRLLDGAIKQGMWLMLQNGHLLIRFVRELEKHLDRI 4564
            .:..||  ....:....|::|..:. ..|.:.::.|:|.|.|:||:|.||...::.:|||.|..:
Mouse  4052 HVEDLA--AEQNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSL 4114

  Fly  4565 ENPHPDFRLWITTDPTPTFPIGILQKSLKVVTEPPNGLKLNLRSTYFKVRQERLESCSHVAFRPL 4629
            : ||..|||::|.:..|..|:.:|:.....|.|||.|:|.|:..|:..:...|:....:...| |
Mouse  4115 Q-PHACFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERAR-L 4177

  Fly  4630 VYVLAFFHAVVQERRKYDKLGWNIAYDFNDTDFDVCTEILRTYLTRCGTG-------KIPWNSLK 4687
            .::||:|||::|||.:|..|||:..|:|.::|.....:.:.|:|.....|       ||||::||
Mouse  4178 YFLLAWFHAIIQERLRYAPLGWSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALK 4242

  Fly  4688 YLIGEVMYGGRVIDDFDRRITNCYMNEYMGDFLFD-EFKVFHFYEDDNVDYCLPEEETILKEDYI 4751
            .|:.:.:|||||.::||:|:.|.::........|| |||: ....|.:.|..:|  :.|.:|:::
Mouse  4243 TLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKL-ACKVDGHKDIQMP--DGIRREEFV 4304

  Fly  4752 AHIDKLPLVNKPDVFGLHPNAEIGYYTMAARNIWNSLIELQPQTGEG------TGGISRDDFIDS 4810
            ..::.||....|...||..|||....|....::.:.::::|....|.      |...:|.|....
Mouse  4305 QWVELLPDAQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKARTDSTSD 4369

  Fly  4811 VAAGILKKLPPAFETWRIRKQIQMSLSP---TGVVLLQELDRFNLLVVRI-KKTLELLRKAIA-- 4869
            .....::.|......|  ...|..:|||   |...:...|.||....|:: .|.|:.:|:.:|
Mouse  4370 GRPAWMRTLHTTASNW--LHLIPQTLSPLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADV 4432

  Fly  4870 -----GEIGMDNVLDNIANSLFNGLLPAAWSKLAPATCKQLASWLEHL--RLRAVQ-YKYWTLSG 4926
                 |:....|.|..:.|.|..|:||.:||.........:..|:...  |::.:| ......||
Mouse  4433 VQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISQAAASG 4497

  Fly  4927 -----EPLVMWLSGLHIPQSYLTALVQIACRRNAWPLDRSTLFTYVTKFADPDDVEERPVTGCL- 4985
                 :.:.:.|.||.:|::|:||..|...:.|:|.|:...|...||.      .:...:..|.
Mouse  4498 GAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTA------SQSATLDACSF 4556

  Fly  4986 -VHGLYIEGGRFDLATNQLARSHPKVLVEELAILAVEPIEAHRL-------KLQNTYLAPVYTTS 5042
             |.||.::|.  ..:.|:|:.|:        ||..|.|:...|.       |..:....|||...
Mouse  4557 GVTGLKLQGA--TCSNNKLSLSN--------AISTVLPLTQLRWVKQTSAEKKASVVTLPVYLNF 4611

  Fly  5043 LRRNAMGVGLVF--EANLATSEDLSHWILQGVCL 5074
            .|.:     |:|  :..:||.||...:..:||.:
Mouse  4612 TRAD-----LIFTVDFEIATKEDPRSFYERGVAV 4640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc98D	NP_524541.3	DHC_N1	523..983	CDD:285571	108/543 (20%)
		DHC_N2	1798..2201	CDD:285579	120/420 (29%)
		P-loop_NTPase	2338..2565	CDD:304359	115/237 (49%)
		P-loop_NTPase	2654..2788	CDD:304359	65/136 (48%)
		P-loop_NTPase	2976..3246	CDD:304359	78/282 (28%)
		P-loop_NTPase	3378..3645	CDD:304359	91/286 (32%)
		MT	3658..3989	CDD:289543	90/349 (26%)
		AAA_9	4017..4233	CDD:289547	82/215 (38%)
		Dynein_heavy	4374..5068	CDD:281078	194/758 (26%)
Dync1h1	NP_084514.2	Stem. /evidence=ECO:0000250	2..1865		445/2220 (20%)
		DHC_N1	238..830	CDD:285571	135/711 (19%)
		Interaction with DYNC1I2. /evidence=ECO:0000250	446..701		55/280 (20%)
		Interaction with DYNC1LI2. /evidence=ECO:0000250	649..800		34/178 (19%)
		DYN1	1044..4327	CDD:227570	992/3532 (28%)
		DHC_N2	1321..1719	CDD:285579	117/413 (28%)
		P-loop_NTPase	1866..2103	CDD:304359	115/237 (49%)
		AAA 1. /evidence=ECO:0000250	1866..2097		113/231 (49%)
		AAA 2. /evidence=ECO:0000250	2178..2450		90/277 (32%)
		P-loop_NTPase	2217..2357	CDD:304359	66/139 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2388..2408		3/19 (16%)
		AAA 3. /evidence=ECO:0000250	2554..2803		72/261 (28%)
		P-loop_NTPase	2565..2826	CDD:304359	77/274 (28%)
		AAA 4. /evidence=ECO:0000250	2897..3166		86/303 (28%)
		P-loop_NTPase	2907..3185	CDD:304359	91/277 (33%)
		Stalk. /evidence=ECO:0000250	3187..3498		80/326 (25%)
		MT	3199..3530	CDD:289543	90/347 (26%)
		AAA 5. /evidence=ECO:0000250	3551..3780		86/229 (38%)
		AAA_9	3559..3774	CDD:289547	82/215 (38%)
		Dynein_heavy	3920..4630	CDD:281078	193/754 (26%)
		AAA 6. /evidence=ECO:0000250	4003..4219		63/227 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710