DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1894 and KAT6A

DIOPT Version :9

Sequence 1:	NP_651620.1	Gene:	CG1894 / 43378	FlyBaseID:	FBgn0039585	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_011542958.1	Gene:	KAT6A / 7994	HGNCID:	13013	Length:	2048	Species:	Homo sapiens

Alignment Length:	415	Identity:	138/415 - (33%)
Similarity:	208/415 - (50%)	Gaps:	57/415 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PLGDQDGISSKLPDIPRALQLTNAKESSATRGLGQSASKSEMGKSQLQNDSSLQKNIQE----TK 75
            |..:|||              .:.|:.:..|..|.....:|       .|..|.::|||    |.
Human   453 PTDNQDG--------------WDGKQENEERLFGSQEIMTE-------KDMELFRDIQEQALQTC 496

  Fly    76 TITGSCIEAQRIGATPKKQLEGVKEPNMISLLHTNASSNVDDRQ-------RQETIDNEKSDVQK 133
            .:...|           |||..    |.||..  .:...:::::       :|:|:..:|..|..
Human   497 AVVVMC-----------KQLYW----NWISTF--TSGIRLEEQRAADGKTLKQQTVPQQKVGVTG 544

  Fly   134 EKEDAKVKVIRNIEKVQFGRYEIETTSSSPYPVINDKATTIYVCEFCLKYMCLRKSYSYHLYDCK 198
            ..:..    :|....::||:|||.|..|||||....:...:|:||||||||..|.....|:..|.
Human   545 PPDPQ----VRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCG 605

  Fly   199 KRCPPGSLLYRKDNIYIYEVDGHKEQLYCQCLCLMSKLFLENKKILYSSSSFLFYILCLKDKDGE 263
            ...||.:.:|||:||.::||||:...:|||.|||::||||::|.:.|....||||:|...|..|.
Human   606 WFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGC 670

  Fly   264 HFAGYFAREK-TMLNINLNCILVLPPYMRKGYGKLLIDLSYEISRREACIGGPKKPLSKVARLCY 327
            |..|||::|| .....|::||::||.|.|||||:.|||.||.:|:||...|.|:||||.:.||.|
Human   671 HLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSY 735

  Fly   328 LSYWGHILLNLLRHHSSPDLVTIEELSKATGFREEDIISTLEFMGMTKYYKVDHIMFYTTSSIIE 392
            ::||..::|..| :|.:...::|::|||.||...:||.|||..:.|.. ::.|..:......:|:
Human   736 MAYWKSVILECL-YHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLD-FRSDQFVIIRREKLIQ 798

  Fly   393 DRRGLAQFKKPRLTIHRNRLSWKTP 417
            |.....|.....:.:....|.| ||
Human   799 DHMAKLQLNLRPVDVDPECLRW-TP 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1894	NP_651620.1	NAT_SF	130..395	CDD:302625	109/265 (41%)
CG1894	NP_651620.1	MOZ_SAS	202..378	CDD:280097	81/176 (46%)
KAT6A	XP_011542958.1	H15	85..162	CDD:197772
		PHD1_MOZ_MORF	205..262	CDD:277090
		PHD2_KAT6A_6B	264..310	CDD:277002
		NAT_SF	549..823	CDD:302625	113/281 (40%)
		MOZ_SAS	609..787	CDD:280097	81/179 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820