DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1894 and Kat6a

DIOPT Version :10

Sequence 1:NP_651620.1 Gene:CG1894 / 43378 FlyBaseID:FBgn0039585 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_001094040.1 Gene:Kat6a / 306571 RGDID:1304892 Length:1998 Species:Rattus norvegicus


Alignment Length:418 Identity:134/418 - (32%)
Similarity:197/418 - (47%) Gaps:84/418 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KENRSGDHLKYQPLGDQDGISSKLPDIPRALQLTNAKESSATRGLGQSASKSEMGKSQL--QNDS 65
            |.||... ..:.|..:|||..||                       |.:.:...|..::  :.|.
  Rat   440 KGNRKSS-TSHWPTDNQDGWESK-----------------------QESEERLFGSQEIMTERDM 480

  Fly    66 SLQKNIQETKTITGSCIEAQRIGATPKKQLEGVKEPNMISLLHTNASSNVDDRQRQETIDNEKSD 130
            .|.::|||.        ..|::|.|      |..:|.                            
  Rat   481 ELFRDIQEQ--------ALQKVGVT------GPPDPQ---------------------------- 503

  Fly   131 VQKEKEDAKVKVIRNIEKVQFGRYEIETTSSSPYPVINDKATTIYVCEFCLKYMCLRKSYSYHLY 195
                        :|....::||:|||.|..|||||....:...:|:||||||||..|.....|:.
  Rat   504 ------------VRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMK 556

  Fly   196 DCKKRCPPGSLLYRKDNIYIYEVDGHKEQLYCQCLCLMSKLFLENKKILYSSSSFLFYILCLKDK 260
            .|....||.:.:|||:||.::||||:...:|||.|||::||||::|.:.|....||||:|...|.
  Rat   557 KCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDV 621

  Fly   261 DGEHFAGYFAREK-TMLNINLNCILVLPPYMRKGYGKLLIDLSYEISRREACIGGPKKPLSKVAR 324
            .|.|..|||::|| .....|::||::||.|.|||||:.|||.||.:|:||...|.|:||||.:.|
  Rat   622 KGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGR 686

  Fly   325 LCYLSYWGHILLNLLRHHSSPDLVTIEELSKATGFREEDIISTLEFMGMTKYYKVDHIMFYTTSS 389
            |.|::||..::|..| :|.:...::|::|||.||...:||.|||..:.|.. ::.|..:......
  Rat   687 LSYMAYWKSVILECL-YHQNDKQISIKKLSKLTGVCPQDITSTLHHLRMLD-FRSDQFVIIRREK 749

  Fly   390 IIEDRRGLAQFKKPRLTIHRNRLSWKTP 417
            :|:|.....|.....:.:....|.| ||
  Rat   750 LIQDHMAKLQLNLRPVDVDPECLRW-TP 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1894NP_651620.1 zf-MYST 143..197 CDD:407644 23/53 (43%)
MOZ_SAS 202..378 CDD:460362 81/176 (46%)
Kat6aNP_001094040.1 Required for activation of RUNX1-1. /evidence=ECO:0000250|UniProtKB:Q92794 1..144
Required for nuclear localization. /evidence=ECO:0000250 52..166
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..93
H15 85..162 CDD:197772
Interaction with PML. /evidence=ECO:0000250 144..662 93/299 (31%)
PHD1_MOZ_MORF 205..262 CDD:277090
PHD2_KAT6A_6B 264..310 CDD:277002
Interaction with RUNX1-1. /evidence=ECO:0000250 312..662 93/299 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..377
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..464 10/47 (21%)
Catalytic. /evidence=ECO:0000250 486..776 119/346 (34%)
PLN00104 <502..776 CDD:215056 112/316 (35%)
Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250 505..808 113/275 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 783..947
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 982..1079
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1096..1175
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1195..1436
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1450..1567
Interaction with PML. /evidence=ECO:0000250 1510..1735
Interaction with RUNX1-2. /evidence=ECO:0000250 1510..1635
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1630..1702
Required for activation of RUNX1-2. /evidence=ECO:0000250 1907..1942
Blue background indicates that the domain is not in the aligned region.

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