DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1894 and Kat6a

DIOPT Version :9

Sequence 1:	NP_651620.1	Gene:	CG1894 / 43378	FlyBaseID:	FBgn0039585	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001074618.1	Gene:	Kat6a / 244349	MGIID:	2442415	Length:	2003	Species:	Mus musculus

Alignment Length:	418	Identity:	134/418 - (32%)
Similarity:	196/418 - (46%)	Gaps:	84/418 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KENRSGDHLKYQPLGDQDGISSKLPDIPRALQLTNAKESSATRGLGQSASKSEMGKSQL--QNDS 65
            |.||......: |..:|||..||                       |...:...|..::  :.|.
Mouse   441 KGNRKSSTSDW-PTDNQDGWESK-----------------------QENEERLFGSQEIMTERDM 481

  Fly    66 SLQKNIQETKTITGSCIEAQRIGATPKKQLEGVKEPNMISLLHTNASSNVDDRQRQETIDNEKSD 130
            .|.::|||.        ..|::|.|      |..:|.
Mouse   482 ELFRDIQEQ--------ALQKVGVT------GPPDPQ---------------------------- 504

  Fly   131 VQKEKEDAKVKVIRNIEKVQFGRYEIETTSSSPYPVINDKATTIYVCEFCLKYMCLRKSYSYHLY 195
                        :|....::||:|||.|..|||||....:...:|:||||||||..|.....|:.
Mouse   505 ------------VRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMK 557

  Fly   196 DCKKRCPPGSLLYRKDNIYIYEVDGHKEQLYCQCLCLMSKLFLENKKILYSSSSFLFYILCLKDK 260
            .|....||.:.:|||:||.::||||:...:|||.|||::||||::|.:.|....||||:|...|.
Mouse   558 KCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDV 622

  Fly   261 DGEHFAGYFAREK-TMLNINLNCILVLPPYMRKGYGKLLIDLSYEISRREACIGGPKKPLSKVAR 324
            .|.|..|||::|| .....|::||::||.|.|||||:.|||.||.:|:||...|.|:||||.:.|
Mouse   623 KGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGR 687

  Fly   325 LCYLSYWGHILLNLLRHHSSPDLVTIEELSKATGFREEDIISTLEFMGMTKYYKVDHIMFYTTSS 389
            |.|::||..::|..| :|.:...::|::|||.||...:||.|||..:.|.. ::.|..:......
Mouse   688 LSYMAYWKSVILECL-YHQNDKQISIKKLSKLTGVCPQDITSTLHHLRMLD-FRSDQFVIIRREK 750

  Fly   390 IIEDRRGLAQFKKPRLTIHRNRLSWKTP 417
            :|:|.....|.....:.:....|.| ||
Mouse   751 LIQDHMAKLQLNLRPVDVDPECLRW-TP 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1894	NP_651620.1	NAT_SF	130..395	CDD:302625	108/265 (41%)
CG1894	NP_651620.1	MOZ_SAS	202..378	CDD:280097	81/176 (46%)
Kat6a	NP_001074618.1	Required for activation of RUNX1-1. /evidence=ECO:0000250\|UniProtKB:Q92794	1..144
		Required for nuclear localization. /evidence=ECO:0000250	52..166
		H15	85..162	CDD:197772
		Interaction with PML. /evidence=ECO:0000250	144..663		93/299 (31%)
		PHD1_MOZ_MORF	205..262	CDD:277090
		PHD2_KAT6A_6B	264..310	CDD:277002
		Interaction with RUNX1-1. /evidence=ECO:0000250	312..663		93/299 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..377
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..466		10/48 (21%)
		Catalytic. /evidence=ECO:0000250	487..777		119/346 (34%)
		MOZ_SAS	<503..777	CDD:332306	112/316 (35%)
		Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250	506..809		113/275 (41%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	644..648		2/3 (67%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	653..659		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..939
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	983..1083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1197..1438
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1533
		Interaction with PML. /evidence=ECO:0000250	1511..1740
		Interaction with RUNX1-2. /evidence=ECO:0000250	1511..1636
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1546..1568
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1631..1707
		Required for activation of RUNX1-2. /evidence=ECO:0000250	1912..1947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820