DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1894 and KAT7

DIOPT Version :9

Sequence 1:	NP_651620.1	Gene:	CG1894 / 43378	FlyBaseID:	FBgn0039585	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_008998.1	Gene:	KAT7 / 11143	HGNCID:	17016	Length:	611	Species:	Homo sapiens

Alignment Length:	423	Identity:	141/423 - (33%)
Similarity:	219/423 - (51%)	Gaps:	34/423 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NRSGDHLKYQPLGDQDGISSKLPDIPRALQLTNAKESS---ATRGLG----QSASKSEMGKSQLQ 62
            |.|.|..|.:.......|..::        |::.::.:   |||...    |...|.::.:.:.:
Human   214 NLSADECKVRAQSRDKQIEERM--------LSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKK 270

  Fly    63 NDSSLQKNIQETKTITGSCIEAQRIGATPKKQLEGVKEPNMISLLHTNASSNVDDRQRQETIDNE 127
            .:|.|.|. |:.|.:.    ..|..|.|.:..||.:.....:.|...        .|.:.:.|.|
Human   271 RNSGLSKE-QKEKYME----HRQTYGNTREPLLENLTSEYDLDLFRR--------AQARASEDLE 322

  Fly   128 KSDVQKEKEDAKVKVIRNIEKVQFGRYEIETTSSSPYPVINDKATTIYVCEFCLKYMCLRKSYSY 192
            |..:|.:..:..    ..|:.:.|||||::|...||||....:...:|:||||||||..:.....
Human   323 KLRLQGQITEGS----NMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRR 383

  Fly   193 HLYDCKKRCPPGSLLYRKDNIYIYEVDGHKEQLYCQCLCLMSKLFLENKKILYSSSSFLFYILCL 257
            |:..|..:.|||..:|||.:|.::||||.|.::|||.|||::||||::|.:.|....||||::..
Human   384 HMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTE 448

  Fly   258 KDKDGEHFAGYFAREK-TMLNINLNCILVLPPYMRKGYGKLLIDLSYEISRREACIGGPKKPLSK 321
            .|..|.|..|||::|| :.||.|::|||.:|.|||:||||:|||.||.:|:.|..:|.|::|||.
Human   449 ADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSD 513

  Fly   322 VARLCYLSYWGHILLNLLRHHSSPDLVTIEELSKATGFREEDIISTLEFMGMTKYYKVDHIMFYT 386
            :..:.|.|||..:||..| |:.....::|:|:|:.|.....||:|||:.:.|.||:|..|::...
Human   514 LGLISYRSYWKEVLLRYL-HNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKR 577

  Fly   387 TSSIIEDRRGLAQFKKPRLTIHRNRLSWKTPTG 419
            ...|.|.....|:......|:..:.|.|..|.|
Human   578 QDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKG 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1894	NP_651620.1	NAT_SF	130..395	CDD:302625	109/265 (41%)
CG1894	NP_651620.1	MOZ_SAS	202..378	CDD:280097	82/176 (47%)
KAT7	NP_008998.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..173
		zf-C2HC	184..212	CDD:396216
		PLN00104	<324..609	CDD:215056	113/289 (39%)
		acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:28334966, ECO:0000269\|PubMed:31827282, ECO:0007744\|PDB:5GK9, ECO:0007744\|PDB:6MAK	475..477		1/1 (100%)
		WM-3835 inhibitor binding. /evidence=ECO:0000269\|PubMed:31827282, ECO:0007744\|PDB:6MAJ	483..488		3/4 (75%)
		acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:28334966, ECO:0000269\|PubMed:31827282, ECO:0007744\|PDB:5GK9, ECO:0007744\|PDB:6MAK	483..488		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820