DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moca-cyp and PPIG

DIOPT Version :9

Sequence 1:	NP_733246.1	Gene:	Moca-cyp / 43374	FlyBaseID:	FBgn0039581	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_004783.2	Gene:	PPIG / 9360	HGNCID:	14650	Length:	754	Species:	Homo sapiens

Alignment Length:	871	Identity:	289/871 - (33%)
Similarity:	433/871 - (49%)	Gaps:	182/871 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RPRCFFDISLGGLGMGRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIFHRVVKD 76
            ||||||||::.....||:|||||:||.|||.||||.|||||||.|..|.|.|.||..:|||||||
Human     7 RPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKD 71

  Fly    77 FMVQAGDFSAGNGTGGESIYGGTFEDESFEKKHDRPFLLSMANRGKNTNGSQFFITTQPAPHLDN 141
            ||||.||||.|||.||||||||.||||||..||::.||||||||||:||||||||||:|.||||.
Human    72 FMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDG 136

  Fly   142 IHVVFGQVISGQELVRQLEGLPVDRNSRPLQDAAIANCGELVRQTKAKKEKKHKRRSTATEDSNS 206
            .||||||||||||:||::|....|..|:|..:..|.:||||:.::|.|||:|.:.:|:::..|:|
Human   137 HHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSS 201

  Fly   207 EESE-----------AEAKVVRKAKKKKRSRKDTKSQSDSEDNETSRGNGKHDQTPQDDDEDREE 260
            .:|:           ::::...:.|.|||.:|..|:....:..:..|...|...:.:.:.|:.
Human   202 SDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENL-- 264

  Fly   261 GELHPLVTITKIDPNEIPEV-SNKFLMRAERSKSLDREERGARGQDRDRGKDQDRDRSRNNFGWS 324
             |..|..|:.   |.|||.: .|:||||....|: |.:||        :.::::|:|..|
Human   265 -EAQPQSTVR---PEEIPPIPENRFLMRKSPPKA-DEKER--------KNRERERERECN----- 311

  Fly   325 KKQAPPTS------------RSGRIVKGRGVFRFRTPSRSRS-----RSTTPPHWKHAQKRTIKL 372
                ||.|            ||||.:||||..|:||||||||     ||.|||||:...:|..::
Human   312 ----PPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRM 372

  Fly   373 -------------SDLERIEE--ESKMREEEMKRREH----ERKRRHEEATKNPKQSFFELSHAS 418
                         |:|..|:|  .|.:|.:|.|..:|    |...|..|..|..|
Human   373 RVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVK---------- 427

  Fly   419 TYGGKITPDRFSPEHKAKSKDTADRGKAKEREKAGEKDKARDVTPVKRRKSMDMNALDYEQQTES 483
                         :||:.||:                   ||:    ||.|
Human   428 -------------DHKSNSKE-------------------RDI----RRNS-------------- 442

  Fly   484 EVESEDEEQLKVKPPSKQDIR---VEPSTSKDRNAKRDERKPTEEKAKPKRSRSRSPRRQSPARR 545
              |.:|:.:.|||..:|...|   .|.|.||:|::|.:.   .|||.  .||||:....::...:
Human   443 --EKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNR---NEEKR--MRSRSKGRDHENVKEK 500

  Fly   546 QQRSPARRPGQNYNQNQNQNQNQNQNQNQLNRGNRRNPFADRDRRRRSRSQDNEYRNRYPLSPIR 610
            :::|.::...|..::::.:::......|:.:....:    ::|||.:|||::.:..
Human   501 EKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSK----EKDRRAQSRSRECDIT--------- 552

  Fly   611 GRGSPSGDRRRQQRSRSQNRRQDSPSQRRQLSPGRKRQDSPSKKRPNSTERKWRDSPERKRDDSH 675
             :|..|.:.|.::||||::|      .||..|....|..|.||:     ..::|:...|:|..|.
Human   553 -KGKHSYNSRTRERSRSRDR------SRRVRSRTHDRDRSRSKE-----YHRYREQEYRRRGRSR 605

  Fly   676 DRKREASPNWKRDDSPARKRKDSANRKREDSQDKKIQDSKRQEDSAGKKREDSPSKKRKDSDKKR 740
            .|:|...|...|.....|:|:||.:.:||:||.:.....:.||..:..::|:|.|:||..|..:.
Human   606 SRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRD 670

  Fly   741 QDSPVKRQESPGRKRQDSPERKRRDSPDRRRKDSPARRRQESSGRRRQDSDGRRRRESSGNRRSR 805
            .:|....:|....:.|....:.::.|.|...|.|..:.:::...|...:.:         |::|:
Human   671 HNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKE---------NQKSK 726

  Fly   806 SRGRWHSSSRSR------SPSTSRSR 825
            .:...|...:::      ||.|...:
Human   727 GQENDHVHEKNKKFDHESSPGTDEDK 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moca-cyp	NP_733246.1	cyclophilin	13..180	CDD:294131	114/166 (69%)
Moca-cyp	NP_733246.1	SH3-RhoG_link	635..>718	CDD:293215	23/82 (28%)
PPIG	NP_004783.2	cyclophilin	8..175	CDD:412213	114/166 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..754		170/696 (24%)
		PTZ00121	<392..752	CDD:173412	102/460 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2443
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	1	1.000	-	-		otm40622
orthoMCL	1	0.900	-	-		OOG6_105724
Panther	1	1.100	-	-	LDO	PTHR11071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8699
SonicParanoid	1	1.000	-	-		X5641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860