DRSC/TRiP Functional Genomics Resources

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Protein Alignment Moca-cyp and Ppid

DIOPT Version :10

Sequence 1:NP_733246.1 Gene:Moca-cyp / 43374 FlyBaseID:FBgn0039581 Length:970 Species:Drosophila melanogaster
Sequence 2:NP_080628.1 Gene:Ppid / 67738 MGIID:1914988 Length:370 Species:Mus musculus


Alignment Length:411 Identity:143/411 - (34%)
Similarity:200/411 - (48%) Gaps:72/411 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RDAGATRPRCFFDISLGGLGMGRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIF 70
            :.:.:..||.|||:.:||..:||||.|||.|:.||||||||||||||||.|..|||.|.:||..|
Mouse     9 KPSNSKNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGTGSTTGKPLHFKGCPF 73

  Fly    71 HRVVKDFMVQAGDFSAGNGTGGESIYGGTFEDESFEKKHDRPFLLSMANRGKNTNGSQFFITTQP 135
            ||::|.||:|.||||..||||||||||..||||:|..||||..||||||.|.|||||||||||.|
Mouse    74 HRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGPNTNGSQFFITTVP 138

  Fly   136 APHLDNIHVVFGQVISGQELVRQLEGLPVDRNSRPLQDAAIANCGELVRQTKAKKEKKHKRRSTA 200
            .||||..||||||||.|..:.|.||.:.|: ..:|.:...||.||||                  
Mouse   139 TPHLDGKHVVFGQVIKGLGVARTLENVEVN-GEKPAKLCVIAECGEL------------------ 184

  Fly   201 TEDSNSEESEAEAKVVRKAKKKKRSRKDTKSQSDSEDNETSRGNG-KHDQTPQDDDEDREEGELH 264
                                          .:.|........|:| .|...|:|.|.|.::.:..
Mouse   185 ------------------------------KEGDDWGIFPKDGSGDSHPDFPEDADIDLKDVDKI 219

  Fly   265 PLVTITKIDPNEIPEVSNKFLMRAERSKSLDREERGARGQDRDRGKDQDRDRSR---------NN 320
            .|::      .::..:.|.|........::.:..:..|..|..:...:..||||         .|
Mouse   220 LLIS------EDLKNIGNTFFKSQNWEMAIKKYAKVLRYVDSSKAVIEKADRSRLQPIALSCVLN 278

  Fly   321 FGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSRSTTPPHWKHAQKRTIKLSDLERIEE----E 381
            .|..|.:.  ::..|.|......... .||.:::.......|:..::....|:||::.:|    :
Mouse   279 IGACKLKM--SNWQGAIDSCLEALEM-DPSNTKALYRKAQGWQGLKEYDQALADLKKAQEIAPGD 340

  Fly   382 SKMREEEMKRREHERKRRHEE 402
            ..::.|.:|.::..:.::.:|
Mouse   341 KAIQAELLKVKQMIKAQKDKE 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Moca-cypNP_733246.1 cyclophilin 13..180 CDD:469651 107/166 (64%)
PRK12678 612..>804 CDD:237171
PpidNP_080628.1 cyclophilin_ABH_like 16..182 CDD:238907 107/166 (64%)
Chaperone activity. /evidence=ECO:0000250 185..215 8/29 (28%)
TPR 213..>367 CDD:440225 24/158 (15%)
Interaction with HSP90AB1. /evidence=ECO:0000250 214..370 24/157 (15%)
TPR repeat 223..251 CDD:276809 2/33 (6%)
TPR repeat 272..302 CDD:276809 5/31 (16%)
TPR repeat 307..335 CDD:276809 4/27 (15%)
TPR repeat 341..364 CDD:276809 3/21 (14%)
Blue background indicates that the domain is not in the aligned region.

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