DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Moca-cyp and Ppid

DIOPT Version :9

Sequence 1:	NP_733246.1	Gene:	Moca-cyp / 43374	FlyBaseID:	FBgn0039581	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_080628.1	Gene:	Ppid / 67738	MGIID:	1914988	Length:	370	Species:	Mus musculus

Alignment Length:	411	Identity:	143/411 - (34%)
Similarity:	200/411 - (48%)	Gaps:	72/411 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RDAGATRPRCFFDISLGGLGMGRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIF 70
            :.:.:..||.|||:.:||..:||||.|||.|:.||||||||||||||||.|..|||.|.:||..|
Mouse     9 KPSNSKNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGTGSTTGKPLHFKGCPF 73

  Fly    71 HRVVKDFMVQAGDFSAGNGTGGESIYGGTFEDESFEKKHDRPFLLSMANRGKNTNGSQFFITTQP 135
            ||::|.||:|.||||..||||||||||..||||:|..||||..||||||.|.|||||||||||.|
Mouse    74 HRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGPNTNGSQFFITTVP 138

  Fly   136 APHLDNIHVVFGQVISGQELVRQLEGLPVDRNSRPLQDAAIANCGELVRQTKAKKEKKHKRRSTA 200
            .||||..||||||||.|..:.|.||.:.|: ..:|.:...||.||||
Mouse   139 TPHLDGKHVVFGQVIKGLGVARTLENVEVN-GEKPAKLCVIAECGEL------------------ 184

  Fly   201 TEDSNSEESEAEAKVVRKAKKKKRSRKDTKSQSDSEDNETSRGNG-KHDQTPQDDDEDREEGELH 264
                                          .:.|........|:| .|...|:|.|.|.::.:..
Mouse   185 ------------------------------KEGDDWGIFPKDGSGDSHPDFPEDADIDLKDVDKI 219

  Fly   265 PLVTITKIDPNEIPEVSNKFLMRAERSKSLDREERGARGQDRDRGKDQDRDRSR---------NN 320
            .|::      .::..:.|.|........::.:..:..|..|..:...:..||||         .|
Mouse   220 LLIS------EDLKNIGNTFFKSQNWEMAIKKYAKVLRYVDSSKAVIEKADRSRLQPIALSCVLN 278

  Fly   321 FGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSRSTTPPHWKHAQKRTIKLSDLERIEE----E 381
            .|..|.:.  ::..|.|......... .||.:::.......|:..::....|:||::.:|    :
Mouse   279 IGACKLKM--SNWQGAIDSCLEALEM-DPSNTKALYRKAQGWQGLKEYDQALADLKKAQEIAPGD 340

  Fly   382 SKMREEEMKRREHERKRRHEE 402
            ..::.|.:|.::..:.::.:|
Mouse   341 KAIQAELLKVKQMIKAQKDKE 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moca-cyp	NP_733246.1	cyclophilin	13..180	CDD:294131	107/166 (64%)
Moca-cyp	NP_733246.1	SH3-RhoG_link	635..>718	CDD:293215
Ppid	NP_080628.1	cyclophilin_ABH_like	16..182	CDD:238907	107/166 (64%)
		Chaperone activity. /evidence=ECO:0000250	185..215		8/29 (28%)
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370		24/157 (15%)
		TPR_11	223..304	CDD:290150	13/89 (15%)
		TPR repeat	223..251	CDD:276809	2/33 (6%)
		TPR repeat	272..302	CDD:276809	5/31 (16%)
		TPR_11	277..338	CDD:290150	12/63 (19%)
		TPR	277..306	CDD:197478	6/31 (19%)
		TPR repeat	307..335	CDD:276809	4/27 (15%)
		TPR_1	308..340	CDD:278916	5/31 (16%)
		TPR repeat	341..364	CDD:276809	3/21 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820