Protein Alignment Moca-cyp and NKTR

DIOPT Version :10

• Sequence 1: NP_733246.1
• Gene: Moca-cyp / 43374
• FlyBaseID: FBgn0039581
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: NP_001336053.1
• Gene: NKTR / 4820
• HGNCID: 7833
• Length: 1463
• Species: Homo sapiens
• Alignment Length: 1148
• Identity: 340/1148 - (29%)
• Similarity: 478/1148 - (41%)
• Gaps: 268/1148 - (23%)

  Fly    12 RPRCFFDISLGGLGMGRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIFHRVVKD 76
            ||:|.|||.:....:|||:|:||:|:.|||.:||..||:||||.|..|||||.|||..||||||:
Human     6 RPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKN 70

  Fly    77 FMVQAGDFSAGNGTGGESIYGGTFEDESFEKKHDRPFLLSMANRGKNTNGSQFFITTQPAPHLDN 141
            ||:|.||||.|||.||||||||.|:||:|..||||.||||||||||:||||||||||:||||||.
Human    71 FMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDG 135

  Fly   142 IHVVFGQVISGQELVRQLEGLPVDRNSRPLQDAAIANCGELVRQTKAKK---EKKHKR------- 196
            :|||||.||||.|::.|:|.|..|..|||..|..:.:||.|.  ||:.|   |||.|:
Human   136 VHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLA--TKSIKDVFEKKRKKPTHSEGS 198

  Fly   197 -----RSTATEDSNSEESEAEAKVVRKAKKK---KRSRKDTKSQSDSEDNETSRGNGKHDQTPQD 253
                 .|:::|.|:..|.|.|....||.|::   |||:|..|..|.||:     ...||...|:.
Human   199 DSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEE-----PRNKHAMNPKG 258

  Fly   254 DDEDREEGELHPLVTITK-----IDPNEIPEV-SNKFLMRAERSKSLDREERGARGQDRDRGKD- 311
            ..|..:..|...:.:..|     :.|.|||.| .|:||:|        |:......:...:..|
Human   259 HSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLR--------RDMPVVTAEPEPKIPDV 315

  Fly   312 ----QDRDRSRNNFGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRS--------RSTTPPHWKH 364
                .|             |.|..|:|||.:||||..|:.||.||||        .|.||||||.
Human   316 APIVSD-------------QKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKE 367

  Fly   365 AQKRT--------------IKLSD--LERIEEES----------------------------KMR 385
            ..:|.              .||||  ..|.:|.|                            :.:
Human   368 EMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRK 432

  Fly   386 EEEMKRREHERKRRHEEATKNPKQ------SFFELSHASTYGGKITPDRFSPEHKAKSKDTADRG 444
            |:::|.::..:|::|....|..|:      |..|.|.:||...|.:.||   |..::|...:...
Human   433 EKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDR---ERSSRSSSLSSHH 494

  Fly   445 KAKEREKAGEKDKARDVTPVKR------RKSMDMNALDYEQQTESEVESEDEEQLKVKPPSKQDI 503
            .:|......:||....:|...|      ..|...:......:|.|:..|....:.|.:..||...
Human   495 SSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGH 559

  Fly   504 RVEPSTSKDRNAKR-DERKPTEEKAKPKR------------------------SRSRSPRRQSPA 543
            |...|.|..:.|.: .|.||.  |.:|.|                        |.|..|.|..|.
Human   560 RKRASKSPRKTASQLSENKPV--KTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPG 622

  Fly   544 RRQQRSPARR------------PGQN----------------YNQNQNQNQNQNQNQNQLNRGNR 580
            ::..:....|            |.|:                :.:.:|...:|:......:|.:.
Human   623 QKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSE 687

  Fly   581 RNPFADRDRRRRSRSQDNEYRNRYPLSPIRGRG-SPSGDRRRQQRSRSQNRRQDSP--------- 635
            .:| ..|.|..||||....|.....|:....|. |||      .||.|:|:..|..
Human   688 SSP-RSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPS------SRSHSRNKYSDHSQCSRSSSYT 745

  Fly   636 ---------SQRRQLSPGRKRQDSPSKKRPNSTER-------KWRDSPERKRDDSHDRKREASPN 684
                     ::||..|.|:|...| .||..:|:|:       |.||.....|..|..|   :|.:
Human   746 SISSDDGRRAKRRLRSSGKKNSVS-HKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESR---SSLD 806

  Fly   685 WKRD-DSPARKRKDSANRKREDSQDKKI---QDSKRQEDSAGKKREDSPSKKR--KD--SDKKRQ 741
            :..| :..:.:...||..|.:..|.::.   |:..|.|:.:..:||...||||  |:  ||..|.
Human   807 YSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRN 871

  Fly   742 DSPVKRQESPGRKRQDSPERKRRDSPDRRRKDS-PARRRQESSGRRRQDSDGR----------RR 795
            .|..||:...|.| .||.....||.....:.|| |:..::|  |....||:..          ..
Human   872 GSKPKRKNYAGSK-WDSESNSERDVTKNSKNDSHPSSDKEE--GEATSDSESEVSEIHIKVKPTT 933

  Fly   796 RESSGNRRSRSRGRWHSSSRSRSP-----STSRSRRRRSRSPLPKLTSALPMSEEREKAAREKMQ 855
            :.|:........|.|.||.:..|.     |.|.|...|.:....|..|...:..|..|..:||::
Human   934 KSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLK 998

  Fly   856 KRAEAAMLMKEHMRN------------EIAKEEERRMEKQRQDDLDKERTTRELNE--------L 900
            .:.:     |:|...            |..:|||..::.::.....||:...|.||        .
Human   999 GKKD-----KKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKT 1058

  Fly   901 ERLKAETLRKLHEEDSVDPDAAASAGSASKTDATSTGAKSKRD 943
            |:...|.|...|:..:|..|........||...:.|...::.:
Human  1059 EKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEEN 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Moca-cyp	NP_733246.1	cyclophilin	13..180	CDD:469651	108/166 (65%)
		PRK12678	612..>804	CDD:237171	61/236 (26%)
NKTR	NP_001336053.1	cyclophilin	7..174	CDD:469651	108/166 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..591		108/434 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	607..627		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..1072		103/432 (24%)
		MSCRAMM_ClfA	<799..988	CDD:468110	49/194 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1129..1156
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1169..1215
		Arg/Ser tandem repeat-rich	1311..1348