DRSC/TRiP Functional Genomics Resources

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Protein Alignment Moca-cyp and NKTR

DIOPT Version :9

Sequence 1:NP_733246.1 Gene:Moca-cyp / 43374 FlyBaseID:FBgn0039581 Length:970 Species:Drosophila melanogaster
Sequence 2:NP_001336053.1 Gene:NKTR / 4820 HGNCID:7833 Length:1463 Species:Homo sapiens


Alignment Length:1148 Identity:340/1148 - (29%)
Similarity:478/1148 - (41%) Gaps:268/1148 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 RPRCFFDISLGGLGMGRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIFHRVVKD 76
            ||:|.|||.:....:|||:|:||:|:.|||.:||..||:||||.|..|||||.|||..||||||:
Human     6 RPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKN 70

  Fly    77 FMVQAGDFSAGNGTGGESIYGGTFEDESFEKKHDRPFLLSMANRGKNTNGSQFFITTQPAPHLDN 141
            ||:|.||||.|||.||||||||.|:||:|..||||.||||||||||:||||||||||:||||||.
Human    71 FMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDG 135

  Fly   142 IHVVFGQVISGQELVRQLEGLPVDRNSRPLQDAAIANCGELVRQTKAKK---EKKHKR------- 196
            :|||||.||||.|::.|:|.|..|..|||..|..:.:||.|.  ||:.|   |||.|:       
Human   136 VHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLA--TKSIKDVFEKKRKKPTHSEGS 198

  Fly   197 -----RSTATEDSNSEESEAEAKVVRKAKKK---KRSRKDTKSQSDSEDNETSRGNGKHDQTPQD 253
                 .|:::|.|:..|.|.|....||.|::   |||:|..|..|.||:     ...||...|:.
Human   199 DSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEE-----PRNKHAMNPKG 258

  Fly   254 DDEDREEGELHPLVTITK-----IDPNEIPEV-SNKFLMRAERSKSLDREERGARGQDRDRGKD- 311
            ..|..:..|...:.:..|     :.|.|||.| .|:||:|        |:......:...:..| 
Human   259 HSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLR--------RDMPVVTAEPEPKIPDV 315

  Fly   312 ----QDRDRSRNNFGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRS--------RSTTPPHWKH 364
                .|             |.|..|:|||.:||||..|:.||.||||        .|.||||||.
Human   316 APIVSD-------------QKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKE 367

  Fly   365 AQKRT--------------IKLSD--LERIEEES----------------------------KMR 385
            ..:|.              .||||  ..|.:|.|                            :.:
Human   368 EMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRK 432

  Fly   386 EEEMKRREHERKRRHEEATKNPKQ------SFFELSHASTYGGKITPDRFSPEHKAKSKDTADRG 444
            |:::|.::..:|::|....|..|:      |..|.|.:||...|.:.||   |..::|...:...
Human   433 EKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDR---ERSSRSSSLSSHH 494

  Fly   445 KAKEREKAGEKDKARDVTPVKR------RKSMDMNALDYEQQTESEVESEDEEQLKVKPPSKQDI 503
            .:|......:||....:|...|      ..|...:......:|.|:..|....:.|.:..||...
Human   495 SSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGH 559

  Fly   504 RVEPSTSKDRNAKR-DERKPTEEKAKPKR------------------------SRSRSPRRQSPA 543
            |...|.|..:.|.: .|.||.  |.:|.|                        |.|..|.|..|.
Human   560 RKRASKSPRKTASQLSENKPV--KTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPG 622

  Fly   544 RRQQRSPARR------------PGQN----------------YNQNQNQNQNQNQNQNQLNRGNR 580
            ::..:....|            |.|:                :.:.:|...:|:......:|.:.
Human   623 QKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSE 687

  Fly   581 RNPFADRDRRRRSRSQDNEYRNRYPLSPIRGRG-SPSGDRRRQQRSRSQNRRQDSP--------- 635
            .:| ..|.|..||||....|.....|:....|. |||      .||.|:|:..|..         
Human   688 SSP-RSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPS------SRSHSRNKYSDHSQCSRSSSYT 745

  Fly   636 ---------SQRRQLSPGRKRQDSPSKKRPNSTER-------KWRDSPERKRDDSHDRKREASPN 684
                     ::||..|.|:|...| .||..:|:|:       |.||.....|..|..|   :|.:
Human   746 SISSDDGRRAKRRLRSSGKKNSVS-HKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESR---SSLD 806

  Fly   685 WKRD-DSPARKRKDSANRKREDSQDKKI---QDSKRQEDSAGKKREDSPSKKR--KD--SDKKRQ 741
            :..| :..:.:...||..|.:..|.::.   |:..|.|:.:..:||...||||  |:  ||..|.
Human   807 YSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRN 871

  Fly   742 DSPVKRQESPGRKRQDSPERKRRDSPDRRRKDS-PARRRQESSGRRRQDSDGR----------RR 795
            .|..||:...|.| .||.....||.....:.|| |:..::|  |....||:..          ..
Human   872 GSKPKRKNYAGSK-WDSESNSERDVTKNSKNDSHPSSDKEE--GEATSDSESEVSEIHIKVKPTT 933

  Fly   796 RESSGNRRSRSRGRWHSSSRSRSP-----STSRSRRRRSRSPLPKLTSALPMSEEREKAAREKMQ 855
            :.|:........|.|.||.:..|.     |.|.|...|.:....|..|...:..|..|..:||::
Human   934 KSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLK 998

  Fly   856 KRAEAAMLMKEHMRN------------EIAKEEERRMEKQRQDDLDKERTTRELNE--------L 900
            .:.:     |:|...            |..:|||..::.::.....||:...|.||        .
Human   999 GKKD-----KKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKT 1058

  Fly   901 ERLKAETLRKLHEEDSVDPDAAASAGSASKTDATSTGAKSKRD 943
            |:...|.|...|:..:|..|........||...:.|...::.:
Human  1059 EKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEEN 1101

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Moca-cypNP_733246.1 cyclophilin 13..180 CDD:294131 108/166 (65%)
SH3-RhoG_link 635..>718 CDD:293215 24/111 (22%)
NKTRNP_001336053.1 cyclophilin 7..174 CDD:320812 108/166 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 187..591 108/434 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..627 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..1072 103/432 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1156
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1169..1215
Arg/Ser tandem repeat-rich 1311..1348
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 231 1.000 Domainoid score I2443
eggNOG 1 0.900 - - E1_COG0652
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1403619at2759
OrthoFinder 1 1.000 - - FOG0000032
OrthoInspector 1 1.000 - - otm40622
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11071
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.880

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