DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Moca-cyp and Cwc27

DIOPT Version :9

Sequence 1:	NP_733246.1	Gene:	Moca-cyp / 43374	FlyBaseID:	FBgn0039581	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	XP_017446439.1	Gene:	Cwc27 / 361887	RGDID:	1310697	Length:	471	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	149/566 - (26%)
Similarity:	213/566 - (37%)	Gaps:	163/566 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIFHRVVKDFMVQAGDFSAGNGTG 91
            |.|..||::..|||...||..||.           :..|...||||||..|:||.|| ..|.|||
  Rat    22 GDIDIELWSKEAPKACRNFIQLCL-----------EAYYDNTIFHRVVPGFIVQGGD-PTGTGTG 74

  Fly    92 GESIYGGTFEDESFEK-KHDRPFLLSMANRGKNTNGSQFFITTQPAPHLDNIHVVFGQVISGQEL 155
            |||:||..|:||...: :.:|..|::|||.|.:.||||||.|...|..|:|.|.:||:| :|..:
  Rat    75 GESVYGAPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKV-TGDTV 138

  Fly   156 --VRQLEGLPVDRNSRPLQDAAIANCGELV--------------RQTKAKKE-KKHKRRSTATED 203
              :.:|..:.:|...||.....|.:|..|.              ::.||::| ||.|.:.|....
  Rat   139 YNMLRLTEVDIDDEERPRNPHRIKSCEVLFNPFDDIIPREIKKPKKEKAEEEIKKLKPKGTKNFS 203

  Fly   204 --SNSEESEAEAKVVRKAKKKKRSRKDTKSQSD------------SEDNETSRGNGKHDQTPQD- 253
              |..||:|.|.:.|.:..:..:.|  :||..|            :.::|.....|..:...||
  Rat   204 LLSFGEEAEEEEEEVNRVSQSMKGR--SKSSHDLLKDDPHLSSVPAVESEKDDATGDLEDLSQDA 266

  Fly   254 -DDEDREEGELHPLVTITKIDPNEIPEVSNKFLMRAERSKSLDREERGARGQDRDRGKDQDRDRS 317
             ||....:|.:               |...|.|||...:|.|                  .:|.|
  Rat   267 EDDSVEHDGSM---------------EEDEKNLMRERIAKRL------------------KKDAS 298

  Fly   318 RNNFGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSRSTTPPHWKHAQKRTIKLSDLERIEEES 382
            .|                  ||..|....:..|||                           ||.
  Rat   299 AN------------------VKSAGDGEKKPASRS---------------------------EEL 318

  Fly   383 KMREEEMKRREHERKRRHEEATKNPKQSFFELSHASTYGGKITPDRFSPEH-KAKSKDTADRGKA 446
            :....::||.....|::.|.|||..|.|..|         :..||....|: :.|.|..|.|
  Rat   319 RKEARQLKRELLAAKQKKESATKAEKGSEEE---------EAVPDGPVAEYRREKQKYEALR--- 371

  Fly   447 KEREKAGEKDKARDVTPVKRRKSMDMNALDYEQQTESEVESEDEE------------QLKVKPPS 499
            |::.|.|...:.:.:..:.:.||....|:....:..:|.|.||:|            ..|||..|
  Rat   372 KQQPKKGTSREDQTLALLSQFKSKLTQAITEMPENCAEAEVEDDEGWMSHVLQFEDKTRKVKDAS 436

  Fly   500 KQDIRVEPSTSKDRNAKRDERKPTEEKAKPKRSRSRSPRRQSPARR 545
            .||        .|.....|.|.|..   |.:|..|:...|:...||
  Rat   437 MQD--------SDTFEIYDPRNPVN---KRRREESKKLLREKKERR 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moca-cyp	NP_733246.1	cyclophilin	13..180	CDD:294131	61/155 (39%)
Moca-cyp	NP_733246.1	SH3-RhoG_link	635..>718	CDD:293215
Cwc27	XP_017446439.1	cyclophilin_CeCYP16-like	8..177	CDD:238906	63/167 (38%)
Cwc27	XP_017446439.1	TMEM119	<308..>359	CDD:292352	17/86 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900