Protein Alignment Moca-cyp and Nktr

DIOPT Version :9

• Sequence 1: NP_733246.1
• Gene: Moca-cyp / 43374
• FlyBaseID: FBgn0039581
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: XP_030099969.1
• Gene: Nktr / 18087
• MGIID: 97346
• Length: 1556
• Species: Mus musculus
• Alignment Length: 1187
• Identity: 334/1187 - (28%)
• Similarity: 475/1187 - (40%)
• Gaps: 311/1187 - (26%)

  Fly     5 KRDAGA------TRPRCFFDISLGGLGMGRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKL 63
            :|.|.|      .||:|.|||.:....:|||:|:||:|:.|||.:||..||:||||.|..|||||
Mouse    95 RRPAAALAMGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKL 159

  Fly    64 QYKGVIFHRVVKDFMVQAGDFSAGNGTGGESIYGGTFEDESFEKKHDRPFLLSMANRGKNTNGSQ 128
            .|||..||||||:||:|.||||.|||.||||||||.|:||:|..||||.||||||||||:|||||
Mouse   160 CYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQ 224

  Fly   129 FFITTQPAPHLDNIHVVFGQVISGQELVRQLEGLPVDRNSRPLQDAAIANCGEL-VRQTKAKKEK 192
            |||||:||||||.:|||||.||||.|::.|:|.|..|..|||..|..:.:||.| .:.||...||
Mouse   225 FFITTKPAPHLDGVHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKLTKDVFEK 289

  Fly   193 KHKR-----------RSTATEDSNSEESEAEAKVVRKAKKKKR-----SRKDTKSQSDSEDNETS 241
            |.|:           ||:::.:|:| |||.|.:.:|:.:.|:|     ::|..|..|.||:...
Mouse   290 KRKKPTCSEGSDSSSRSSSSSESSS-ESEVERETIRRRRHKRRPKVRHAKKRRKEMSSSEEPRR- 352

  Fly   242 RGNGKHDQTPQDDDEDREEGELHPLVTITK-----IDPNEIPEV-SNKFLMRAERSKSLDREERG 300
                |...:|:...|..:..|...:.:.||     :.|.|||.| .|:||:|.:........|:.
Mouse   353 ----KRTVSPEGYSERSDVNEKRSVDSNTKREKPVVRPEEIPPVPENRFLLRRDMPAITVEPEQN 413

  Fly   301 ARG-----QDRDRGKDQDRDRSRNNFGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSR----- 355
            ...     .|                     |.|..|:|||.:||||..|:.||.||||.
Mouse   414 IPDVAPVVSD---------------------QKPSVSKSGRKIKGRGTIRYHTPPRSRSHSESKD 457

  Fly   356 ---STTPPHWKHAQKRT--------------IKLSD--LERIEEES------------------- 382
               |.||||||...:|.              .||||  ..|.:|.|
Mouse   458 DDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLST 522

  Fly   383 -KMREEEMKRREHERKRRHEEATKNPKQSFFELSHASTYGGKIT-----PDRFSPEHKAKS---K 438
             :..:...|:...|:|.:|::..|..|..   ..|..|...:|.     |.| ||.|:.||   :
Mouse   523 ARHSDGHHKKHRKEKKFKHKKKAKKQKHC---RRHRQTKKRRIVMPDLEPSR-SPTHRMKSSCVR 583

  Fly   439 DTADRGKAKEREKAGEKDKAR---DVTPVKRRKSMDMNALDYEQQTESEVESEDEEQLK-VKPPS 499
            :...|..:.....:.::|.::   |........|.|    .|..::.|..:|....:.: |...|
Mouse   584 ERRSRASSSSSHHSSKRDWSKSDQDDGSASTHSSRD----SYRSKSHSRSDSRGSSRSRAVSKSS 644

  Fly   500 KQDIRVEPSTSKDRNAKR------------DERKPTEEKAKPKR--------------------- 531
            .:.:....|.|..|:..|            .|.||.  |.:|.|
Mouse   645 SRSLNRSKSRSSSRSGPRRTSISPKKPAQLSENKPV--KTEPLRPSVPQNGNVLVQPVAAENIPV 707

  Fly   532 ---SRSRSPRRQSPARRQQRSPARR------------PGQ------NYNQNQNQNQNQNQNQNQL 575
               |.|..|.|..|.::..:....|            |.|      |.....:.:....:.:...
Mouse   708 IPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPVQSTYSLTNIKATVSSSSYHKREKPSE 772

  Fly   576 NRGNRRNPFADRDRRRRSRSQDNEYRNR-----YPLSPIRGRGSPSG---DRRRQQRSRSQNRRQ 632
            :.|:..:.::||......||.....|:|     |..|  |.|..|:.   .|....||.|.|:..
Mouse   773 SDGSAYSKYSDRSSGSSGRSGSKSSRSRSSSRSYTRS--RSRSLPTSRSLSRSPSSRSHSPNKYS 835

  Fly   633 DSPSQRRQLS-------PGRKRQDSPSKKRPNSTERKWRDSPERKRDDSHDRKREASPNWKRDDS 690
            |.....|..|       .||:.....::|:..::.::.|.:.|:.....:.|.||.|
Mouse   836 DGSQHSRSSSYTSVSSDDGRRAMFRSNRKKSVTSHKRHRSNSEKTLHSKYVRGREKS-------- 892

  Fly   691 PARKRKDSANRK----REDSQDKKIQ-----DSKRQ------EDSAGKKREDSP---------SK 731
             :|.||.|.:|.    ..||....:|     :.::|      .|..||.||:..         ||
Mouse   893 -SRHRKYSESRSSLDYSSDSDQSHVQVYSAPEKEKQGKVEALNDKQGKGREEGKPKPEWECPRSK 956

  Fly   732 KRKDSDKKRQDSPVKRQESPGRKRQDSPERKRRDSPDRRRKDSPARRRQESSGRRRQDSDGR--- 793
            ||...|..|.||..|.:...|.| .||.....:| ..:.||..|.|..::..|....||:..
Mouse   957 KRTPKDHSRDDSVSKGKNCAGSK-WDSESNSEQD-VTKSRKSDPRRGSEKEEGEASSDSESEVGQ 1019

  Fly   794 --------------------------RRRESS-----------GNRRSRSRGRWHSSSRSRSPST 821
                                      ||.:||           ||.|...:.:.||....:...|
Mouse  1020 SHIKAKPPAKPPTSTFLPGSDGAWKSRRPQSSASESESSCSNLGNIRGEPQKQKHSKDDLKGDHT 1084

  Fly   822 SRSRRRRSRSPLPKLTSALPMSEEREKAAREKMQKRAEAAMLMKEHMRNEIAKEEERRME-KQRQ 885
            .|:|                   |:.||.::|..|..:...........|...:||..|. ||..
Mouse  1085 KRAR-------------------EKSKAKKDKKHKAPKRKQAFHWQPPLEFGDDEEEEMNGKQVT 1130

  Fly   886 DDLDKERTTRELNELERLKAETLRKLHEEDS---------VDPDAAASAGSASKTDATSTGAKSK 941
            .|..::|...|..|..:.....:.|..:|.|         ::.|..|..|.    |.:|..|..|
Mouse  1131 QDPKEKRHVSEKCEAVKDGIPNVEKTCDEGSSPSKPKKGTLEQDPLAEGGH----DPSSCPAPLK 1191

  Fly   942 RDSSSEN-----RHREK 953
            .:.::.:     :|.|:
Mouse  1192 VEDNTASSPPSAQHLEE 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Moca-cyp	NP_733246.1	cyclophilin	13..180	CDD:294131	108/166 (65%)
		SH3-RhoG_link	635..>718	CDD:293215	20/104 (19%)
Nktr	XP_030099969.1	cyclophilin	109..276	CDD:381853	108/166 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2422
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	1	1.000	-	-		otm42698
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880