Protein Alignment Moca-cyp and CWC27

DIOPT Version :9

• Sequence 1: NP_733246.1
• Gene: Moca-cyp / 43374
• FlyBaseID: FBgn0039581
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: NP_005860.2
• Gene: CWC27 / 10283
• HGNCID: 10664
• Length: 472
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 152/564 - (26%)
• Similarity: 216/564 - (38%)
• Gaps: 158/564 - (28%)

  Fly    27 GRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIFHRVVKDFMVQAGDFSAGNGTG 91
            |.|..||::..|||...||..||.           :..|...||||||..|:||.|| ..|.|:|
Human    22 GDIDIELWSKEAPKACRNFIQLCL-----------EAYYDNTIFHRVVPGFIVQGGD-PTGTGSG 74

  Fly    92 GESIYGGTFEDESFEK-KHDRPFLLSMANRGKNTNGSQFFITTQPAPHLDNIHVVFGQVISGQEL 155
            ||||||..|:||...: :.:|..|::|||.|.:.||||||.|...|..|:|.|.:||:| :|..:
Human    75 GESIYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLGRADELNNKHTIFGKV-TGDTV 138

  Fly   156 --VRQLEGLPVDRNSRPLQDAAIANC------------GELVRQTKAKKE---KKHKRRSTAT-- 201
              :.:|..:.:|.:.||.....|.:|            .|:.|..|.|.|   ||.|.:.|..
Human   139 YNMLRLSEVDIDDDERPHNPHKIKSCEVLFNPFDDIIPREIKRLKKEKPEEEVKKLKPKGTKNFS 203

  Fly   202 -----EDSNSEESEAEAKVVRKAKKKKRSR----KDTKSQSDSEDNETSRGNGKHDQTPQDDDED 257
                 |::..||.|.. :|.:..|.|.:|.    ||....|.....|:.:|:.. |.....:||.
Human   204 LLSFGEEAEEEEEEVN-RVSQSMKGKSKSSHDLLKDDPHLSSVPVVESEKGDAP-DLVDDGEDES 266

  Fly   258 REEGELHPLVTITKIDPNEIPEVSNKFLMRAERSKSLDREERGARGQDRDRGKDQDRDRSRNNFG 322
            .|..|.        ||.:|      |.|||...:|.|                  .:|.|.|
Human   267 AEHDEY--------IDGDE------KNLMRERIAKKL------------------KKDTSAN--- 296

  Fly   323 WSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSRSTTPPHWKHAQ--KRTIKLSDLERIEEESKMR 385
                           ||..|.......|.|||....    |.|:  ||.:..:..:::|..:|..
Human   297 ---------------VKSAGEGEVEKKSVSRSEELR----KEARQLKRELLAAKQKKVENAAKQA 342

  Fly   386 EEEMKRREHERKRRHEEATKNPKQSFFELSHASTYGGKITPDRFSPEH-KAKSKDTADRGKAKER 449
            |          ||..||                    :..||....|: :.|.|..|.|   |::
Human   343 E----------KRSEEE--------------------EAPPDGAVAEYRREKQKYEALR---KQQ 374

  Fly   450 EKAGEKDKARDVTPVKRRKSMDMNALDYEQQT---ESEVESE----------DEEQLKVKPPSKQ 501
            .|.|...:.:.:..:.:.||....|:....:.   |:|||.:          :::..|||..|.|
Human   375 SKKGTSREDQTLALLNQFKSKLTQAIAETPENDIPETEVEDDEGWMSHVLQFEDKSRKVKDASMQ 439

  Fly   502 DIRVEPSTSKDRNAKRDERKPTEEKAKPKRSRSRSPRRQSPARR 545
            |        .|.....|.|.|..   |.:|..|:...|:...||
Human   440 D--------SDTFEIYDPRNPVN---KRRREESKKLMREKKERR 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Moca-cyp	NP_733246.1	cyclophilin	13..180	CDD:294131	62/167 (37%)
		SH3-RhoG_link	635..>718	CDD:293215
CWC27	NP_005860.2	cyclophilin_CeCYP16-like	8..178	CDD:238906	62/168 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..386		58/268 (22%)
		DUF5401	<302..>472	CDD:375164	46/217 (21%)
		CWC27_CTD	376..428	CDD:412084	9/51 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..472		19/84 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810