DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moca-cyp and Nktr

DIOPT Version :9

Sequence 1:	NP_733246.1	Gene:	Moca-cyp / 43374	FlyBaseID:	FBgn0039581	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	XP_038938667.1	Gene:	Nktr / 100364165	RGDID:	2321593	Length:	1516	Species:	Rattus norvegicus

Alignment Length:	1133	Identity:	332/1133 - (29%)
Similarity:	466/1133 - (41%)	Gaps:	250/1133 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RPRCFFDISLGGLGMGRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIFHRVVKD 76
            ||:|.|||.:....:|||:|:||:|:.|||.:||..||:||||.|..|||||.|||..||||||:
  Rat    65 RPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKN 129

  Fly    77 FMVQAGDFSAGNGTGGESIYGGTFEDESFEKKHDRPFLLSMANRGKNTNGSQFFITTQPAPHLDN 141
            ||:|.||||.|||.||||||||.|:||:|..||||.||||||||||:||||||||||:||||||.
  Rat   130 FMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDG 194

  Fly   142 IHVVFGQVISGQELVRQLEGLPVDRNSRPLQDAAIANCGELVRQTKAKKE--KKHKRRSTATEDS 204
            :|||||.||||.|::.|:|.|..|..|||..|..:.:||.|.  ||..|:  :|.:::.|.:|||
  Rat   195 VHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLA--TKLTKDVFEKKRKKPTHSEDS 257

  Fly   205 -----------NSEESEAEAKVVRKAKKKKR-----SRKDTKSQSDSEDNETSRGNGKHDQTPQD 253
                       :|.|||.|.:.:|:.:.|:|     ::|..|..|.||:....|.......:.:.
  Rat   258 DSSSNSSSSSESSSESEVERERIRRRRHKRRPKVRHTKKRRKEMSGSEELRRKRTVSPEGYSERS 322

  Fly   254 DDEDREEGELHPLVTITKIDPNEIPEV-SNKFLMRAERSKSLDREERGARGQDRDRGKD-----Q 312
            |..::..|:.:.......:.|.|||.| .|:||:|        |:......:......|     .
  Rat   323 DVNEKRSGDSNTKREKPVVRPEEIPPVPENRFLLR--------RDVPAVAVEPEQNVPDVAPVVS 379

  Fly   313 DRDRSRNNFGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSR--------STTPPHWKHAQKRT 369
            |             |.|..|:|||.:||||..|:.||.||||.        |.||||||...:|.
  Rat   380 D-------------QKPSVSKSGRKIKGRGTIRYHTPPRSRSHSESEDDDSSETPPHWKEEMQRL 431

  Fly   370 --------------IKLSDLERIEEESKMREEEMKRRE--------------------HERKRRH 400
                          .||||    ...|:..|..:.:|.                    |.||||.
  Rat   432 RAYRPPSGEKWSKGDKLSD----PCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSDGHHRKRRK 492

  Fly   401 EEATKNPKQSFFE---LSHASTYGGKIT------PDRFSPEHKAKSKDTADR------------- 443
            |:..|:.|::..:   ..|..|...:|.      |.| ||.|:.||....:|
  Rat   493 EKKLKHKKKAKKQKHCRRHRQTKKRRIVMPPDLEPSR-SPTHRVKSSSVGERRPHASSSSQCSSK 556

  Fly   444 ---GKAKEREKAGEKDKARDVTPVKRRKSMDMNALDYEQQTESEVESEDEEQLKVKPPSKQDIRV 505
               .|:...:::.....:||....|.....|... ....:..||..|....:.|.:..|:...|.
  Rat   557 RDWSKSDRDDRSASTRSSRDSYRSKCHSGSDSRG-SSRSRAASESSSRSHNRSKSRSSSRSGPRR 620

  Fly   506 EPSTSKDRNAKRDERKPTEEKAKPKRSR------------------------SRSPRRQSPARRQ 546
            ..|.|..:.|:..|.||.  |.:|.||.                        |..|.|..|.::.
  Rat   621 TTSVSPKKPAQLSENKPV--KTEPLRSSMPQNGSVLVQPVAAENIPVIPLSDSPPPSRWKPGQKP 683

  Fly   547 QRSPARR---------------------------PGQNYNQNQNQNQNQNQNQNQLNRGNRRNPF 584
            .:....|                           ...:|::.:..:::.....::.:..:..:..
  Rat   684 WKPSYERIQEMKAKTTHLLPIQITYNLTNVKGTVSSSSYHKREKASESDGSAYSKYSDRSSGSSG 748

  Fly   585 ADRDRRRRSRSQDNEY---RNR-YPLSPIRGRGSPS---------GDRRRQQRSRS-------QN 629
            ..|.:..||||....|   |:| .|.|....| |||         .|..|..||.|       ..
  Rat   749 RSRSKSSRSRSSSRSYTRSRSRSVPTSRSLSR-SPSSRFHSPDKYSDGSRHSRSSSYTSVSSDNG 812

  Fly   630 RRQDSPSQRRQLSPGRKRQDSPSKKRPNSTERKWRDSPERKRDDSHDRKREASPNWKRDDSPAR- 693
            ||....|.|::.....||..|.|:|.|:||..|.|:...|.|..|..|   :|.::..|...:.
  Rat   813 RRATFRSSRKKSITSNKRHRSSSEKTPHSTYAKGREKSSRHRKYSESR---SSLDYSSDSEQSHV 874

  Fly   694 KRKDSANRKREDSQDKKI---QDSKRQEDSAGKKREDSPSKKRKDS----DKKRQDSPVKRQESP 751
            :...||..|.:..:.:.:   |...|:|..:..:.|.|.||||...    |..|.||..|.:...
  Rat   875 QGVHSAPEKEKQGKVEMLNGKQGKGREEGKSKPEWECSHSKKRTLKGDLPDHSRGDSVSKGKNCA 939

  Fly   752 GRKRQDSPERKRRDSPDRRRKDSPARRRQESSGRRRQDSDGRRRRE------------------S 798
            |.| .||.....:| ..:.||..|.|...:..|....||:....:.                  |
  Rat   940 GSK-WDSESNSEQD-VTKSRKSDPRRCSDKEEGEASSDSESEVGQSHIKAKPPAKPPTNTSLPGS 1002

  Fly   799 SG---NRRSRSRGRWHSSSRSRSPSTSRSRRRRSRSPLPKLTSALPMSEEREKAAREKMQKRAEA 860
            .|   :|||||     |:|.|.|..::....|........|..:|....|:.||.::|..|..:.
  Rat  1003 DGAWKSRRSRS-----SASESESSCSNLGNTRVEPQKQKHLKDSLKGEREKSKAKKDKRHKAPKR 1062

  Fly   861 AMLMKEHMRNEIAKEEERRME---KQRQDDLDKERTTRELNELERLKAETLRKLHEEDSVDPDAA 922
            ..........|..:|||...|   ||...|..:::...|  :.|.:|..|           |...
  Rat  1063 KQAFHWQPPLEFGEEEEEEEEVNGKQLMQDPKEKKHVSE--KYEAVKDNT-----------PKGE 1114

  Fly   923 ASAGSASKTDATSTGAKSKRDSSSENRH 950
            .:....|..:....|. .::||.:|..|
  Rat  1115 KTCNEGSCPNKPKMGT-LEQDSLAEGEH 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moca-cyp	NP_733246.1	cyclophilin	13..180	CDD:294131	108/166 (65%)
Moca-cyp	NP_733246.1	SH3-RhoG_link	635..>718	CDD:293215	23/86 (27%)
Nktr	XP_038938667.1	cyclophilin	66..233	CDD:412213	108/166 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	1	1.000	-	-		otm44764
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11071
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020