Protein Alignment Gfat2 and GFPT2

DIOPT Version :10

• Sequence 1: NP_651617.1
• Gene: Gfat2 / 43373
• FlyBaseID: FBgn0039580
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_005101.1
• Gene: GFPT2 / 9945
• HGNCID: 4242
• Length: 682
• Species: Homo sapiens
• Alignment Length: 689
• Identity: 455/689 - (66%)
• Similarity: 565/689 - (82%)
• Gaps: 13/689 - (1%)

  Fly     1 MCGIFAYLNYLTPKSRQEVLDLLLQGLKRLEYRGYDSTGIAIDALNSGEAQS--IMLVKRTGKVK 63
            |||||||:||..|::|:|:.:.|::||:|||||||||.|:|||. |:.|.:.  |.|||:.||||
Human     1 MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDG-NNHEVKERHIQLVKKRGKVK 64

  Fly    64 VLEDAVAEVCRGQDYSLPIDTHIGIAHTRWATHGVPSEVNSHPQRSDEDNSFVVVHNGIITNYKD 128
            .|::.:.:. ...|..:..:||.||||||||||||||.|||||||||:.|.|||:||||||||||
Human    65 ALDEELYKQ-DSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHNGIITNYKD 128

  Fly   129 VKTLLEKRGYVFESDTDTEVIAKLVHHLW--QQHPGYTFGELVEQAIQQLEGAFAIAFKSKHFPG 191
            ::..||.:||.|||:||||.||||:.:::  ::....||..|||:.|||||||||:.|||.|:||
Human   129 LRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSVHYPG 193

  Fly   192 ECVASRRGSPLLVGIKAKTKLATDHIPILYAKAHRPHGQP--QQQAYQLLPPGDCNAEFQPLERK 254
            |.||:|||||||:|:::|.||:|:.|||||......:.:.  :.:..:|    |.:|....:..|
Human   194 EAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMKRL----DSSACLHAVGDK 254

  Fly   255 EVEYFFASDASAVIEHTNRVIYLEDDDVAAVKSDGTLSIHRLNKSSDDPHAREIITLKMEIQQIM 319
            .||:||||||||:||||||||:|||||:||| :||.|||||:.:|:.|..:|.|.||:||:||||
Human   255 AVEFFFASDASAIIEHTNRVIFLEDDDIAAV-ADGKLSIHRVKRSASDDPSRAIQTLQMELQQIM 318

  Fly   320 KGNYDYFMLKEIFEQPESVVNTMRGRMRFDTQTVVLGGIKEYIPEIKRCRRLMLIACGTSYHSAV 384
            |||:..||.||||||||||.||||||:.|:|.||:|||:|:::.||:|||||::|.||||||:||
Human   319 KGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIVIGCGTSYHAAV 383

  Fly   385 ATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYCKQRGALIVGVT 449
            ||||:|||||||||||||||||||||||:|||||||||||||||||||:||||||.||||.||||
Human   384 ATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKDRGALTVGVT 448

  Fly   450 NTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQRRLEIIDGLSQ 514
            |||||||.||:.|||||||||||||||||||||||||||||.|:|||||:|||.||.|||.||..
Human   449 NTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQNRRQEIIRGLRS 513

  Fly   515 LDEHIRTVLKLNSQVQQLAKELYEHKSLLIMGRGFNFATCLEGALKVKELTYMHSEGILAGELKH 579
            |.|.|:.||.|..::..||.|||..:|||:||||:|:|||||||||:||:|||||||||||||||
Human   514 LPELIKEVLSLEEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKH 578

  Fly   580 GPLALVDKEMPVLMIVLRDPVYTKCMNALQQVTSRKGRPILICEEGDNETMSFSTRSLQIPRTVD 644
            |||||:||:|||:|::::||.:.||.|||||||:|:||||::|.:.|.|:..|:.:::::|.|||
Human   579 GPLALIDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVD 643

  Fly   645 CLQGVLTVIPLQLLSYHIAVLRGCDVDCPRNLAKSVTVE 683
            ||||:|:||||||||:|:|||||.|||.|||||||||||
Human   644 CLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gfat2	NP_651617.1	PLN02981	1..683	CDD:215531	453/687 (66%)
GFPT2	NP_005101.1	PLN02981	1..682	CDD:215531	453/687 (66%)