DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gfat2 and gfpt2

DIOPT Version :9

Sequence 1:	NP_651617.1	Gene:	Gfat2 / 43373	FlyBaseID:	FBgn0039580	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001029093.1	Gene:	gfpt2 / 569945	ZFINID:	ZDB-GENE-071113-1	Length:	681	Species:	Danio rerio

Alignment Length:	687	Identity:	438/687 - (63%)
Similarity:	551/687 - (80%)	Gaps:	10/687 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGIFAYLNYLTPKSRQEVLDLLLQGLKRLEYRGYDSTGIAIDALNSGEAQSIMLVKRTGKVKVL 65
            ||||||||||..|:.|:::.:.|::||:|||||||||.|||:|.....:...|.|.|:|||||.|
Zfish     1 MCGIFAYLNYRVPRKRRDIFETLVKGLQRLEYRGYDSAGIAVDGPVKDDEAKICLYKKTGKVKAL 65

  Fly    66 EDAVAEVCRGQ--DYSLPIDTHIGIAHTRWATHGVPSEVNSHPQRSDEDNSFVVVHNGIITNYKD 128
            .:   |:.:..  |....:|||.|||||||||||.||.:||||.|||::|.|||:|||||||||:
Zfish    66 NE---EIYKNDSIDLEAELDTHFGIAHTRWATHGEPSPLNSHPHRSDKNNEFVVIHNGIITNYKE 127

  Fly   129 VKTLLEKRGYVFESDTDTEVIAKLVHHLW--QQHPGYTFGELVEQAIQQLEGAFAIAFKSKHFPG 191
            :|..|..:||.||||||||||.||:.:|:  :::...:|..|||:.|:|||||||:.|||.||||
Zfish   128 LKKYLGSKGYEFESDTDTEVIPKLIKYLYDNRENDYVSFSTLVERVIKQLEGAFALVFKSIHFPG 192

  Fly   192 ECVASRRGSPLLVGIKAKTKLATDHIPILYAKAHRPHGQPQQQAYQLLPPGDCNAEFQPLERKEV 256
            |.||:|||||||:||:::.:|:|:.||:.|........:.::..:..:  |..||.....:|..|
Zfish   193 EAVATRRGSPLLIGIRSQYELSTEQIPVQYNCGDSRRDEQEKNLHNGV--GSSNALHSIDDRLAV 255

  Fly   257 EYFFASDASAVIEHTNRVIYLEDDDVAAVKSDGTLSIHRLNKSSDDPHAREIITLKMEIQQIMKG 321
            |::|||||||:|||||:|||:||||||.| .:|.|.:||:.:::.:...|.|.||:||:||||||
Zfish   256 EFYFASDASAIIEHTNKVIYVEDDDVAVV-MEGKLYVHRVKRAAGEDPVRVIQTLQMELQQIMKG 319

  Fly   322 NYDYFMLKEIFEQPESVVNTMRGRMRFDTQTVVLGGIKEYIPEIKRCRRLMLIACGTSYHSAVAT 386
            |:..||.||||||||||.||||||:.||..||.|||:.:::.||||||||::|.||||||:.|||
Zfish   320 NFKAFMQKEIFEQPESVYNTMRGRIFFDPNTVFLGGLTDHLKEIKRCRRLIMIGCGTSYHAGVAT 384

  Fly   387 RQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYCKQRGALIVGVTNT 451
            ||:||||||||||||||||||||.||:||||||||||||||||||||||||||:||||.||:|||
Zfish   385 RQILEELTELPVMVELASDFLDRITPVFRDDVCFFISQSGETADTLMALRYCKKRGALTVGITNT 449

  Fly   452 VGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQRRLEIIDGLSQLD 516
            ||||||||:.||||||||||:||||||||||||:||:||.|:|.||||||:.||.|||.||:||.
Zfish   450 VGSSICRETDCGVHINAGPEVGVASTKAYTSQFVSLIMFGLMMCEDRLSLEPRRQEIISGLNQLP 514

  Fly   517 EHIRTVLKLNSQVQQLAKELYEHKSLLIMGRGFNFATCLEGALKVKELTYMHSEGILAGELKHGP 581
            |.|:.||..:..::.:|:||:..:|||:||||||:|||||||||:||:|||||||||||||||||
Zfish   515 ELIKKVLAQDDNIKTIAEELHHQRSLLVMGRGFNYATCLEGALKIKEITYMHSEGILAGELKHGP 579

  Fly   582 LALVDKEMPVLMIVLRDPVYTKCMNALQQVTSRKGRPILICEEGDNETMSFSTRSLQIPRTVDCL 646
            |||:||.|||:||::||..|.||.|||||||:|:||||:||.:.|.|....:.:::::|:|||||
Zfish   580 LALIDKHMPVIMIIMRDACYQKCHNALQQVTARQGRPIIICCQDDPEISKMAYKTIELPQTVDCL 644

  Fly   647 QGVLTVIPLQLLSYHIAVLRGCDVDCPRNLAKSVTVE 683
            ||:|:||||||:|:|:|||||.|||||||||||||||
Zfish   645 QGILSVIPLQLISFHLAVLRGYDVDCPRNLAKSVTVE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfat2	NP_651617.1	PLN02981	1..683	CDD:215531	436/685 (64%)
		GFAT	2..285	CDD:238366	154/286 (54%)
		SIS_GlmS_GlmD_1	370..495	CDD:240141	106/124 (85%)
		SIS_GlmS_GlmD_2	528..681	CDD:240142	104/152 (68%)
gfpt2	NP_001029093.1	PLN02981	1..681	CDD:215531	436/685 (64%)
		GFAT	2..284	CDD:238366	154/286 (54%)
		SIS_GlmS_GlmD_1	368..493	CDD:240141	106/124 (85%)
		SIS_GlmS_GlmD_2	525..679	CDD:240142	104/153 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573429
Domainoid	1	1.000	235	1.000	Domainoid score	I2296
eggNOG	1	0.900	-	-		E1_COG0449
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68439
Inparanoid	1	1.050	931	1.000	Inparanoid score	I344
OMA	1	1.010	-	-		QHG60617
OrthoDB	1	1.010	-	-		D121801at33208
OrthoFinder	1	1.000	-	-		FOG0001486
OrthoInspector	1	1.000	-	-		mtm6582
orthoMCL	1	0.900	-	-		OOG6_100463
Panther	1	1.100	-	-	LDO	PTHR10937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X945
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770