DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gfat2 and gfpt1

DIOPT Version :9

Sequence 1:	NP_651617.1	Gene:	Gfat2 / 43373	FlyBaseID:	FBgn0039580	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001030153.1	Gene:	gfpt1 / 567861	ZFINID:	ZDB-GENE-070423-1	Length:	682	Species:	Danio rerio

Alignment Length:	691	Identity:	467/691 - (67%)
Similarity:	573/691 - (82%)	Gaps:	17/691 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGIFAYLNYLTPKSRQEVLDLLLQGLKRLEYRGYDSTGIAIDALNSGEAQS----IMLVKRTGK 61
            ||||||||||..|.:|:|:|::|::||:|||||||||.|:.||..||.:.:|    |.|:|:|||
Zfish     1 MCGIFAYLNYHVPHTRREILEVLIKGLRRLEYRGYDSAGVGIDGGNSKDWESNSKCIHLIKQTGK 65

  Fly    62 VKVLEDAVAEVCRGQDYSLPI--DTHIGIAHTRWATHGVPSEVNSHPQRSDEDNSFVVVHNGIIT 124
            |:.|::   |:.|.||..|.:  |.|:||||||||||||||.|||||||||:.|.|:|:||||||
Zfish    66 VQALDE---EIQRQQDIDLDVEFDVHLGIAHTRWATHGVPSPVNSHPQRSDKTNEFIVIHNGIIT 127

  Fly   125 NYKDVKTLLEKRGYVFESDTDTEVIAKLVHHLW--QQHPGYTFGELVEQAIQQLEGAFAIAFKSK 187
            ||||:|..||.:.|.|||:||||.|||||.:::  ::....||..||||..||||||||:.|||.
Zfish   128 NYKDLKKFLESKNYEFESETDTETIAKLVKYMYDNRESNDITFATLVEQVTQQLEGAFALVFKSV 192

  Fly   188 HFPGECVASRRGSPLLVGIKAKTKLATDHIPILYAKAHRPHGQPQQQAYQLLPPGDCNAEFQPLE 252
            ||||:.|.||||.|||:|:::..:|:||||||||    |..|: .::....||..|.:....|::
Zfish   193 HFPGQAVGSRRGGPLLIGVRSDHRLSTDHIPILY----RSSGK-DKKTCNTLPRMDEDTCLFPVD 252

  Fly   253 RKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVKSDGTLSIHRLNKSSDDPHAREIITLKMEIQQ 317
            .|.|||:||||||||||||||||:|||||:||| |||.|||||:.:::.|..||.|.||:||:||
Zfish   253 EKAVEYYFASDASAVIEHTNRVIFLEDDDIAAV-SDGRLSIHRIKRTAGDHPARAIQTLQMELQQ 316

  Fly   318 IMKGNYDYFMLKEIFEQPESVVNTMRGRMRFDTQTVVLGGIKEYIPEIKRCRRLMLIACGTSYHS 382
            |||||:..||.|||||||||||||||||:.|:..||:|||:|::|.||:|||||::||||||||:
Zfish   317 IMKGNFSSFMQKEIFEQPESVVNTMRGRVNFENNTVILGGLKDHIKEIQRCRRLIMIACGTSYHA 381

  Fly   383 AVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYCKQRGALIVG 447
            .|||||:|||||||||||||||||||||||:|||||||||||||||||||:||||||:||||.||
Zfish   382 GVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKERGALTVG 446

  Fly   448 VTNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQRRLEIIDGL 512
            :||||||||.||:.|||||||||||||||||||||||::||||||:|.:||:|:|.||.|||.||
Zfish   447 ITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVALVMFALLMCDDRISVQPRRKEIIQGL 511

  Fly   513 SQLDEHIRTVLKLNSQVQQLAKELYEHKSLLIMGRGFNFATCLEGALKVKELTYMHSEGILAGEL 577
            ..|.:.|:.||.|:.::|:||.|||..||:||||||:::|||||||||:||:|||||||||||||
Zfish   512 RILPDLIKEVLTLDEEIQKLAAELYPQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGEL 576

  Fly   578 KHGPLALVDKEMPVLMIVLRDPVYTKCMNALQQVTSRKGRPILICEEGDNETMSFSTRSLQIPRT 642
            ||||||||||.|||:||::||..||||.||||||.:|:||||:||::.||||::.|.|::::|..
Zfish   577 KHGPLALVDKLMPVIMIIMRDHTYTKCQNALQQVVARQGRPIVICDKEDNETINNSKRTIKVPHC 641

  Fly   643 VDCLQGVLTVIPLQLLSYHIAVLRGCDVDCPRNLAKSVTVE 683
            ||||||:|:||||||||:|:|||||.|||||||||||||||
Zfish   642 VDCLQGILSVIPLQLLSFHLAVLRGYDVDCPRNLAKSVTVE 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfat2	NP_651617.1	PLN02981	1..683	CDD:215531	465/689 (67%)
		GFAT	2..285	CDD:238366	169/290 (58%)
		SIS_GlmS_GlmD_1	370..495	CDD:240141	108/124 (87%)
		SIS_GlmS_GlmD_2	528..681	CDD:240142	111/152 (73%)
gfpt1	NP_001030153.1	PLN02981	1..682	CDD:215531	465/689 (67%)
		GFAT	2..285	CDD:238366	169/290 (58%)
		SIS_GlmS_GlmD_1	369..494	CDD:240141	108/124 (87%)
		SIS_GlmS_GlmD_2	526..680	CDD:240142	111/153 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2296
eggNOG	1	0.900	-	-		E1_COG0449
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	931	1.000	Inparanoid score	I344
OMA	1	1.010	-	-		QHG60617
OrthoDB	1	1.010	-	-		D121801at33208
OrthoFinder	1	1.000	-	-		FOG0001486
OrthoInspector	1	1.000	-	-		mtm6582
orthoMCL	1	0.900	-	-		OOG6_100463
Panther	1	1.100	-	-	O	PTHR10937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X945
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840