DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gfat2 and Gfat1

DIOPT Version :9

Sequence 1:	NP_651617.1	Gene:	Gfat2 / 43373	FlyBaseID:	FBgn0039580	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001015157.2	Gene:	Gfat1 / 3354921	FlyBaseID:	FBgn0287209	Length:	694	Species:	Drosophila melanogaster

Alignment Length:	700	Identity:	571/700 - (81%)
Similarity:	620/700 - (88%)	Gaps:	23/700 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGIFAYLNYLTPKSRQEVLDLLLQGLKRLEYRGYDSTGIAIDALNSGEAQSIMLVKRTGKVKVL 65
            |||||||||||||||||||||||:.||||||||||||||:|||   |.:.::|::||||||||||
  Fly     1 MCGIFAYLNYLTPKSRQEVLDLLVTGLKRLEYRGYDSTGVAID---SPDNKNIVMVKRTGKVKVL 62

  Fly    66 EDAVAEVCRGQDYSLPIDTHIGIAHTRWATHGVPSEVNSHPQRSDEDNSFVVVHNGIITNYKDVK 130
            |:|:.|...|::||.|:.||:|||||||||||||.|.||||.|||::|.||||||||||||.|||
  Fly    63 EEAIQEHFSGREYSEPVLTHVGIAHTRWATHGVPCEKNSHPHRSDDENGFVVVHNGIITNYNDVK 127

  Fly   131 TLLEKRGYVFESDTDTEVIAKLVHHLWQQHPGYTFGELVEQAIQQLEGAFAIAFKSKHFPGECVA 195
            |.|.||||.|||||||||.||||||||:.||.|:|.|||||||.|:|||||||.|||:|||||||
  Fly   128 TFLSKRGYEFESDTDTEVFAKLVHHLWKTHPTYSFRELVEQAILQVEGAFAIAVKSKYFPGECVA 192

  Fly   196 SRRGSPLLVGIKAKTKLATDHIPILYAKAH-----------------RPHGQPQQQAYQLLPPGD 243
            |||.||||||||.||:||||||||||.|..                 |||||.::  ..:||..:
  Fly   193 SRRSSPLLVGIKTKTRLATDHIPILYGKDDKKLCTDQDADSGKPQDIRPHGQSRE--LPVLPRSE 255

  Fly   244 CNAEFQPLERKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVKSDGTLSIHRLNKSSDDPHAREI 308
            ..:||.|||.||||||||||||||||||||||||||||||||: |||||||||.||.||||||||
  Fly   256 STSEFMPLEEKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVR-DGTLSIHRLKKSLDDPHAREI 319

  Fly   309 ITLKMEIQQIMKGNYDYFMLKEIFEQPESVVNTMRGRMRFDTQTVVLGGIKEYIPEIKRCRRLML 373
            .||||||||||||||||||.|||||||:|||||||||:|||...:||||||:|||||||||||||
  Fly   320 TTLKMEIQQIMKGNYDYFMQKEIFEQPDSVVNTMRGRVRFDGNAIVLGGIKDYIPEIKRCRRLML 384

  Fly   374 IACGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYC 438
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   385 IGCGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYC 449

  Fly   439 KQRGALIVGVTNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQ 503
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   450 KQRGALIVGITNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQ 514

  Fly   504 RRLEIIDGLSQLDEHIRTVLKLNSQVQQLAKELYEHKSLLIMGRGFNFATCLEGALKVKELTYMH 568
            |||||:..||:|.:.||.||:|:|:|::|||:||:||||||||||:|||||||||||||||||||
  Fly   515 RRLEILQALSKLADQIRDVLQLDSKVKELAKDLYQHKSLLIMGRGYNFATCLEGALKVKELTYMH 579

  Fly   569 SEGILAGELKHGPLALVDKEMPVLMIVLRDPVYTKCMNALQQVTSRKGRPILICEEGDNETMSFS 633
            ||||:|||||||||||||..|||||||||||||.||||||||||||||.||:||||||.||.:||
  Fly   580 SEGIMAGELKHGPLALVDDSMPVLMIVLRDPVYVKCMNALQQVTSRKGCPIIICEEGDEETKAFS 644

  Fly   634 TRSLQIPRTVDCLQGVLTVIPLQLLSYHIAVLRGCDVDCPRNLAKSVTVE 683
            :|.|:||||||||||:|||||:||||||||||||||||||||||||||||
  Fly   645 SRHLEIPRTVDCLQGILTVIPMQLLSYHIAVLRGCDVDCPRNLAKSVTVE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfat2	NP_651617.1	PLN02981	1..683	CDD:215531	569/698 (82%)
		GFAT	2..285	CDD:238366	215/299 (72%)
		SIS_GlmS_GlmD_1	370..495	CDD:240141	122/124 (98%)
		SIS_GlmS_GlmD_2	528..681	CDD:240142	132/152 (87%)
Gfat1	NP_001015157.2	PLN02981	1..694	CDD:215531	569/698 (82%)
		GFAT	2..297	CDD:238366	215/299 (72%)
		SIS_GlmS_GlmD_1	381..506	CDD:240141	122/124 (98%)
		SIS_GlmS_GlmD_2	539..692	CDD:240142	132/152 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437687
Domainoid	1	1.000	178	1.000	Domainoid score	I1066
eggNOG	1	0.900	-	-		E1_COG0449
Homologene	1	1.000	-	-		H68439
Inparanoid	1	1.050	643	1.000	Inparanoid score	I180
Isobase	1	0.950	-	0	Normalized mean entropy	S298
OMA	1	1.010	-	-		QHG60617
OrthoDB	1	1.010	-	-		D121801at33208
OrthoFinder	1	1.000	-	-		FOG0001486
OrthoInspector	1	1.000	-	-		mtm6582
orthoMCL	1	0.900	-	-		OOG6_100463
Panther	1	1.100	-	-	P	PTHR10937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R488
SonicParanoid	1	1.000	-	-		X945
	15	14.790