DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gfat2 and Gfpt1

DIOPT Version :9

Sequence 1:	NP_651617.1	Gene:	Gfat2 / 43373	FlyBaseID:	FBgn0039580	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	XP_006236885.1	Gene:	Gfpt1 / 297417	RGDID:	1549703	Length:	699	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	460/704 - (65%)
Similarity:	563/704 - (79%)	Gaps:	26/704 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGIFAYLNYLTPKSRQEVLDLLLQGLKRLEYRGYDSTGIAIDALN----SGEAQSIMLVKRTGK 61
            ||||||||||..|::|:|:|:.|::||:|||||||||.|:.:|..|    ...|..|.|:|:.||
  Rat     1 MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGK 65

  Fly    62 VKVLEDAVAEVCRGQDYSLPI--DTHIGIAHTRWATHGVPSEVNSHPQRSDEDNSFVVVHNGIIT 124
            ||.|::   ||.:.||..|.|  |.|:|||||||||||.||.|||||||||::|.|:|:||||||
  Rat    66 VKALDE---EVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIIT 127

  Fly   125 NYKDVKTLLEKRGYVFESDTDTEVIAKLVHHL---WQQHPGYTFGELVEQAIQQLEGAFAIAFKS 186
            ||||:|..||.:||.|||:||||.|||||.::   |:.. ..:|..|||:.|||||||||:.|||
  Rat   128 NYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQ-DVSFTTLVERVIQQLEGAFALVFKS 191

  Fly   187 KHFPGECVASRRGSPLLVGIKAKTKLATDHIPILYAKAHRPHGQP-----QQQAYQLLPPGDCNA 246
            .||||:.|.:|||||||:|::::.||:||||||||..|....|..     .|........|.|..
  Rat   192 VHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTWWGSQAERGKDKKGSCGL 256

  Fly   247 E-------FQPLERKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVKSDGTLSIHRLNKSSDDPH 304
            .       ..|:|.|.|||:||||||||||||||||:||||||||| .||.|||||:.:::.|..
  Rat   257 SRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAV-VDGRLSIHRIKRTARDHP 320

  Fly   305 AREIITLKMEIQQIMKGNYDYFMLKEIFEQPESVVNTMRGRMRFDTQTVVLGGIKEYIPEIKRCR 369
            .|.:.||:||:|||||||:..||.|||||||||||||||||:.||..||.|||:|::|.||:|||
  Rat   321 GRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCR 385

  Fly   370 RLMLIACGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMA 434
            ||:|||||||||:.:||||:|||||||||||||||||||||||:||||||||||||||||||||.
  Rat   386 RLILIACGTSYHAGMATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMG 450

  Fly   435 LRYCKQRGALIVGVTNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRL 499
            |||||:||||.||:||||||||.||:.|||||||||||||||||||||||:|||||||:|.:||:
  Rat   451 LRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRI 515

  Fly   500 SLQQRRLEIIDGLSQLDEHIRTVLKLNSQVQQLAKELYEHKSLLIMGRGFNFATCLEGALKVKEL 564
            |:|:||.||:.||.:|.:.|:.||.::.::|:||.|||..||:||||||:::|||||||||:||:
  Rat   516 SMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEI 580

  Fly   565 TYMHSEGILAGELKHGPLALVDKEMPVLMIVLRDPVYTKCMNALQQVTSRKGRPILICEEGDNET 629
            |||||||||||||||||||||||.|||:||::||..|.||.||||||.:|:|||::||::.|.||
  Rat   581 TYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTET 645

  Fly   630 MSFSTRSLQIPRTVDCLQGVLTVIPLQLLSYHIAVLRGCDVDCPRNLAKSVTVE 683
            :..:.|::::|.:||||||:|:|||||||::|:|||||.|||.|||||||||||
  Rat   646 IKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfat2	NP_651617.1	PLN02981	1..683	CDD:215531	458/702 (65%)
		GFAT	2..285	CDD:238366	171/303 (56%)
		SIS_GlmS_GlmD_1	370..495	CDD:240141	109/124 (88%)
		SIS_GlmS_GlmD_2	528..681	CDD:240142	105/152 (69%)
Gfpt1	XP_006236885.1	PLN02981	1..699	CDD:215531	458/702 (65%)
		GFAT	2..302	CDD:238366	171/303 (56%)
		SIS_GlmS_GlmD_1	386..511	CDD:240141	109/124 (88%)
		SIS_GlmS_GlmD_2	543..697	CDD:240142	105/153 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2305
eggNOG	1	0.900	-	-		E1_COG0449
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	911	1.000	Inparanoid score	I345
OMA	1	1.010	-	-		QHG60617
OrthoDB	1	1.010	-	-		D121801at33208
OrthoFinder	1	1.000	-	-		FOG0001486
OrthoInspector	1	1.000	-	-		mtm9143
orthoMCL	1	0.900	-	-		OOG6_100463
Panther	1	1.100	-	-	O	PTHR10937
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X945
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880