DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gfat2 and GFPT1

DIOPT Version :9

Sequence 1:	NP_651617.1	Gene:	Gfat2 / 43373	FlyBaseID:	FBgn0039580	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	XP_016859290.1	Gene:	GFPT1 / 2673	HGNCID:	4241	Length:	724	Species:	Homo sapiens

Alignment Length:	701	Identity:	458/701 - (65%)
Similarity:	562/701 - (80%)	Gaps:	24/701 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GIFAYLNYLTPKSRQEVLDLLLQGLKRLEYRGYDSTGIAIDALN----SGEAQSIMLVKRTGKVK 63
            ||||||||..|::|:|:|:.|::||:|||||||||.|:..|..|    ...|..|.|:|:.||||
Human    28 GIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLIKKKGKVK 92

  Fly    64 VLEDAVAEVCRGQDYSLPI--DTHIGIAHTRWATHGVPSEVNSHPQRSDEDNSFVVVHNGIITNY 126
            .|::   ||.:.||..|.|  |.|:|||||||||||.||.|||||||||::|.|:|:||||||||
Human    93 ALDE---EVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNY 154

  Fly   127 KDVKTLLEKRGYVFESDTDTEVIAKLVHHLW--QQHPGYTFGELVEQAIQQLEGAFAIAFKSKHF 189
            ||:|..||.:||.|||:||||.|||||.:::  ::....:|..|||:.|||||||||:.|||.||
Human   155 KDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHF 219

  Fly   190 PGECVASRRGSPLLVGIKAKTKLATDHIPILYAKAHRPHGQP-----QQQAYQLLPPGDCNAE-- 247
            ||:.|.:|||||||:|::::.||:||||||||..|....|..     .|........|.||..
Human   220 PGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRV 284

  Fly   248 -----FQPLERKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVKSDGTLSIHRLNKSSDDPHARE 307
                 ..|:|.|.|||:||||||||||||||||:||||||||| .||.|||||:.:::.|...|.
Human   285 DSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAV-VDGRLSIHRIKRTAGDHPGRA 348

  Fly   308 IITLKMEIQQIMKGNYDYFMLKEIFEQPESVVNTMRGRMRFDTQTVVLGGIKEYIPEIKRCRRLM 372
            :.||:||:|||||||:..||.|||||||||||||||||:.||..||.|||:|::|.||:|||||:
Human   349 VQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLI 413

  Fly   373 LIACGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRY 437
            |||||||||:.|||||:|||||||||||||||||||||||:||||||||:|||||||||||.|||
Human   414 LIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSGETADTLMGLRY 478

  Fly   438 CKQRGALIVGVTNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQ 502
            ||:||||.||:||||||||.||:.|||||||||||||||||||||||:|||||||:|.:||:|:|
Human   479 CKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQ 543

  Fly   503 QRRLEIIDGLSQLDEHIRTVLKLNSQVQQLAKELYEHKSLLIMGRGFNFATCLEGALKVKELTYM 567
            :||.||:.||.:|.:.|:.||.::.::|:||.|||..||:||||||:::|||||||||:||:|||
Human   544 ERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYM 608

  Fly   568 HSEGILAGELKHGPLALVDKEMPVLMIVLRDPVYTKCMNALQQVTSRKGRPILICEEGDNETMSF 632
            ||||||||||||||||||||.|||:||::||..|.||.||||||.:|:|||::||::.|.||:..
Human   609 HSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKN 673

  Fly   633 STRSLQIPRTVDCLQGVLTVIPLQLLSYHIAVLRGCDVDCPRNLAKSVTVE 683
            :.|::::|.:||||||:|:|||||||::|:|||||.|||.|||||||||||
Human   674 TKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfat2	NP_651617.1	PLN02981	1..683	CDD:215531	456/699 (65%)
		GFAT	2..285	CDD:238366	170/301 (56%)
		SIS_GlmS_GlmD_1	370..495	CDD:240141	109/124 (88%)
		SIS_GlmS_GlmD_2	528..681	CDD:240142	105/152 (69%)
GFPT1	XP_016859290.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2390
eggNOG	1	0.900	-	-		E1_COG0449
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	910	1.000	Inparanoid score	I365
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60617
OrthoDB	1	1.010	-	-		D121801at33208
OrthoFinder	1	1.000	-	-		FOG0001486
OrthoInspector	1	1.000	-	-		mtm8666
orthoMCL	1	0.900	-	-		OOG6_100463
Panther	1	1.100	-	-	O	PTHR10937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R488
SonicParanoid	1	1.000	-	-		X945
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870