DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gfat2 and gfat-1

DIOPT Version :9

Sequence 1:	NP_651617.1	Gene:	Gfat2 / 43373	FlyBaseID:	FBgn0039580	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001369886.1	Gene:	gfat-1 / 174778	WormBaseID:	WBGene00008546	Length:	725	Species:	Caenorhabditis elegans

Alignment Length:	730	Identity:	436/730 - (59%)
Similarity:	550/730 - (75%)	Gaps:	52/730 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGIFAYLNYLTPKSRQEVLDLLLQGLKRLEYRGYDSTGIAIDALNSGEA--QSIMLVKRTGKVK 63
            |||||||||:||||.|.|::|:|:|||:|:|||||||.|||||..|..|:  .|:.|:::.|||.
Worm     1 MCGIFAYLNFLTPKKRSEIVDILVQGLQRMEYRGYDSAGIAIDGSNEIESPHSSVALLRKAGKVS 65

  Fly    64 VLEDAVAEVCRGQDYSLPIDTHIGIAHTRWATHGVPSEVNSHPQRSDEDNSFVVVHNGIITNYKD 128
            ||.|.:.|.....|..:..:.|.|||||||||||.|.:|||||.||::.|.|:||||||||||::
Worm    66 VLSDFIKESSSDLDMDMEYNIHCGIAHTRWATHGSPRDVNSHPHRSNDKNEFLVVHNGIITNYRE 130

  Fly   129 VKTLLEKRGYVFESDTDTEVIAKLVHHLWQQHPGYTFGELVEQAIQQLEGAFAIAFKSKHFPGEC 193
            :|..|||:|:.|||:|||||||||..|:..::|.::|.:|||..|||||||||:||||..|||:.
Worm   131 IKEYLEKKGHKFESETDTEVIAKLAQHIHDRYPDFSFRQLVETVIQQLEGAFALAFKSSRFPGQL 195

  Fly   194 VASRRGSPLLVGIKAKTKLATDHIPILYAK-------------------AHRPHGQPQQQAYQL- 238
            ||||||||||||||:.::|.|:|.|:.::|                   .|..|.:.:....:.
Worm   196 VASRRGSPLLVGIKSNSRLQTNHFPVSFSKDAGWKWGDEKQTDGRRFMSNHATHLRDETSFVETP 260

  Fly   239 ------------------LPPGDCNAEFQPLERK--EVEYFFASDASAVIEHTNRVIYLEDDDVA 283
                              :...|.....:|.:..  |||||.||||:|:||||.:|::|||||||
Worm   261 NNILDLSIAVRSSNGSAKMEISDSTTAVRPFDSDDWEVEYFVASDAAAIIEHTKQVLFLEDDDVA 325

  Fly   284 AVKSDGTLSIHRLNKSSDD-PHAREIITLKMEIQQIMKGNYDYFMLKEIFEQPESVVNTMRGRMR 347
            .|: ||.|:|||:::.:|: ...||:..|:||:|:||||::..:|.|||||||:|||||||||:
Worm   326 FVE-DGALTIHRISRHADNGEQKREVKLLEMELQEIMKGSFKTYMQKEIFEQPDSVVNTMRGRV- 388

  Fly   348 FDTQTVVLGGIKEYIPEIKRCRRLMLIACGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTP 412
            ..:..|||||||||:|:|||||||:::|||||||||:|.||:||||:||||:||||||||||.||
Worm   389 LPSGQVVLGGIKEYLPDIKRCRRLIMVACGTSYHSAIACRQILEELSELPVVVELASDFLDRETP 453

  Fly   413 IFRDDVCFFISQSGETADTLMALRYCKQRGALIVGVTNTVGSSICRESHCGVHINAGPEIGVAST 477
            |||||||.||||||||||||:||||||.||||.:|||||||||||||||||:|||||||||||||
Worm   454 IFRDDVCLFISQSGETADTLLALRYCKPRGALTIGVTNTVGSSICRESHCGIHINAGPEIGVAST 518

  Fly   478 KAYTSQFISLVMFALVMSEDRLSLQQRRLEIIDGLSQLDEHIRTVLKLNSQVQQLAKELYEHKSL 542
            ||||||.:||:||||.:|:||:|:.:||.||||.|:.|.|.||.||:|:.:|..:||::|:.|||
Worm   519 KAYTSQILSLLMFALTLSDDRISMAKRREEIIDALNDLPELIREVLQLDEKVLDIAKQIYKEKSL 583

  Fly   543 LIMGRGFNFATCLEGALKVKELTYMHSEGILAGELKHGPLALVDKEMPVLMIVLRDPVYTKCMNA 607
            ||||||.|||||||||||:|||:|||.|||::|||||||||:||:.:.:.|:|..|.||.|.:||
Worm   584 LIMGRGLNFATCLEGALKIKELSYMHCEGIMSGELKHGPLAMVDEFLSICMVVCNDRVYKKSLNA 648

  Fly   608 LQQVTSRKGRPILICE----EGDNETMSFSTRSLQIPRTVDCLQGVLTVIPLQLLSYHIAVLRGC 668
            ||||.:|||.||:|.:    |||...|.   ..|::|:||||:|.:||||||||||||||.|.|.
Worm   649 LQQVVARKGAPIIIADCTVPEGDLAGMK---HILRVPKTVDCVQNILTVIPLQLLSYHIAELNGA 710

  Fly   669 DVDCPRNLAKSVTVE 683
            :||.|||||||||||
Worm   711 NVDRPRNLAKSVTVE 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfat2	NP_651617.1	PLN02981	1..683	CDD:215531	434/728 (60%)
		GFAT	2..285	CDD:238366	160/324 (49%)
		SIS_GlmS_GlmD_1	370..495	CDD:240141	105/124 (85%)
		SIS_GlmS_GlmD_2	528..681	CDD:240142	98/156 (63%)
gfat-1	NP_001369886.1	PLN02981	1..725	CDD:215531	434/728 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I1391
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68439
Inparanoid	1	1.050	857	1.000	Inparanoid score	I218
Isobase	1	0.950	-	0	Normalized mean entropy	S298
OMA	1	1.010	-	-		QHG60617
OrthoDB	1	1.010	-	-		D121801at33208
OrthoFinder	1	1.000	-	-		FOG0001486
OrthoInspector	1	1.000	-	-		mtm4763
orthoMCL	1	0.900	-	-		OOG6_100463
Panther	1	1.100	-	-	LDO	PTHR10937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R488
SonicParanoid	1	1.000	-	-		X945
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.960