DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gfat2 and Gfpt1

DIOPT Version :9

Sequence 1:	NP_651617.1	Gene:	Gfat2 / 43373	FlyBaseID:	FBgn0039580	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	XP_036021735.1	Gene:	Gfpt1 / 14583	MGIID:	95698	Length:	695	Species:	Mus musculus

Alignment Length:	697	Identity:	456/697 - (65%)
Similarity:	562/697 - (80%)	Gaps:	34/697 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GIFAYLNYLTPKSRQEVLDLLLQGLKRLEYRGYDSTGIAIDALN----SGEAQSIMLVKRTGKVK 63
            ||||||||..|::|:|:|:.|::||:|||||||||.|:.:|..|    ...|..|.|:|:.||||
Mouse    17 GIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVK 81

  Fly    64 VLEDAVAEVCRGQDYSLPI--DTHIGIAHTRWATHGVPSEVNSHPQRSDEDNSFVVVHNGIITNY 126
            .|::   ||.:.||..|.|  |.|:|||||||||||.|:.|||||||||::|.|:|:||||||||
Mouse    82 ALDE---EVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNY 143

  Fly   127 KDVKTLLEKRGYVFESDTDTEVIAKLVHHL---WQQHPGYTFGELVEQAIQQLEGAFAIAFKSKH 188
            ||:|..||.:||.|||:||||.|||||.::   |:.. ..:|..|||:.|||||||||:.|||.|
Mouse   144 KDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQ-DVSFTTLVERVIQQLEGAFALVFKSVH 207

  Fly   189 FPGECVASRRGSPLLVGIKAKTKLATDHIPILYAKAHRPHGQPQQQAYQLLPPGDCNAE------ 247
            |||:.|.:|||||||:|::::.||:||||||||..     |:.::        |.|...
Mouse   208 FPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRT-----GKDKK--------GSCGLSRVDSTT 259

  Fly   248 -FQPLERKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVKSDGTLSIHRLNKSSDDPHAREIITL 311
             ..|:|.|.|||:||||||||||||||||:||||||||| .||.|||||:.:::.|...|.:.||
Mouse   260 CLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAV-VDGRLSIHRIKRTAGDHPGRAVQTL 323

  Fly   312 KMEIQQIMKGNYDYFMLKEIFEQPESVVNTMRGRMRFDTQTVVLGGIKEYIPEIKRCRRLMLIAC 376
            :||:|||||||:..||.|||||||||||||||||:.||..||.|||:|::|.||:|||||:||||
Mouse   324 QMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIAC 388

  Fly   377 GTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYCKQR 441
            |||||:.|||||:|||||||||||||||||||||||:||||||||||||||||||||.|||||:|
Mouse   389 GTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKER 453

  Fly   442 GALIVGVTNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQRRL 506
            |||.||:||||||||.||:.|||||||||||||||||||||||:|||||||:|.:||:|:|:||.
Mouse   454 GALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRK 518

  Fly   507 EIIDGLSQLDEHIRTVLKLNSQVQQLAKELYEHKSLLIMGRGFNFATCLEGALKVKELTYMHSEG 571
            ||:.||.:|.:.|:.||.::.::|:||.|||..||:||||||:::|||||||||:||:|||||||
Mouse   519 EIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEG 583

  Fly   572 ILAGELKHGPLALVDKEMPVLMIVLRDPVYTKCMNALQQVTSRKGRPILICEEGDNETMSFSTRS 636
            ||||||||||||||||.|||:||::||..|.||.||||||.:|:|||::||::.|.||:..:.|:
Mouse   584 ILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRT 648

  Fly   637 LQIPRTVDCLQGVLTVIPLQLLSYHIAVLRGCDVDCPRNLAKSVTVE 683
            :::|.:||||||:|:|||||||::|:|||||.|||.|||||||||||
Mouse   649 IKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfat2	NP_651617.1	PLN02981	1..683	CDD:215531	454/695 (65%)
		GFAT	2..285	CDD:238366	167/297 (56%)
		SIS_GlmS_GlmD_1	370..495	CDD:240141	110/124 (89%)
		SIS_GlmS_GlmD_2	528..681	CDD:240142	105/152 (69%)
Gfpt1	XP_036021735.1	PLN02981	17..695	CDD:215531	454/695 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2348
eggNOG	1	0.900	-	-		E1_COG0449
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	913	1.000	Inparanoid score	I364
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001486
OrthoInspector	1	1.000	-	-		mtm8899
orthoMCL	1	0.900	-	-		OOG6_100463
Panther	1	1.100	-	-	O	PTHR10937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R488
SonicParanoid	1	1.000	-	-		X945
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860