Protein Alignment CG12516 and ALDH1L2

DIOPT Version :10

• Sequence 1: NP_651615.2
• Gene: CG12516 / 43370
• FlyBaseID: FBgn0039577
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_001029345.2
• Gene: ALDH1L2 / 160428
• HGNCID: 26777
• Length: 923
• Species: Homo sapiens
• Alignment Length: 219
• Identity: 46/219 - (21%)
• Similarity: 84/219 - (38%)
• Gaps: 73/219 - (33%)

  Fly    57 SEAVSESEKEVIEV-SEEPK-EEEVKYAW-----NAPCMMVIFEDGDVNCALHHLVESLQDPFAL 114
            |:..|..|..|:|: :||.| .|.:|..|     |.|                 ::|...|.|..
Human   324 SQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVP-----------------IIEDSTDFFKS 371

  Fly   115 DAVAVILVQEALAEEIENRVKILMKPLDARVANHPCYKRT-----LMKI------DELRPKTIIG 168
            .|.::.:.:  |.|||..:...|      ::.|...|..|     :.|:      ::...:.::
Human   372 GASSMDVAR--LVEEIRQKCGGL------QLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVV- 427

  Fly   169 PSDRVLPDATPIMVRDIPHK-FLG-------DGPTGIITMHIFRT--PFEATQIYRKEYPLPIAS 223
              |.:..:...|||: :|:: |:.       ||.|       :.|  |.:.:.|.:..|    ||
Human   428 --DYISKEVNEIMVK-MPYQCFINGQFTDADDGKT-------YDTINPTDGSTICKVSY----AS 478

  Fly   224 VSIWNERVSSVYDVI-----GMMN 242
            ::..::.|::..|..     |.||
Human   479 LADVDKAVAAAKDAFENGEWGRMN 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12516	NP_651615.2	DUF1487	82..298	CDD:254173	36/192 (19%)
ALDH1L2	NP_001029345.2	Hydrolase domain. /evidence=ECO:0000250|UniProtKB:P28037	23..331		2/6 (33%)
		FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731	1/2 (50%)
		PP-binding	346..>390	CDD:425746	13/62 (21%)
		Aldehyde dehydrogenase domain. /evidence=ECO:0000250|UniProtKB:P28037	438..923		18/77 (23%)
		ALDH_F1L_FTFDH	439..923	CDD:143458	17/76 (22%)