DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trv and HRB1

DIOPT Version :9

Sequence 1:	NP_001163754.3	Gene:	trv / 43362	FlyBaseID:	FBgn0085391	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_014394.2	Gene:	HRB1 / 855728	SGDID:	S000004949	Length:	454	Species:	Saccharomyces cerevisiae

Alignment Length:	234	Identity:	53/234 - (22%)
Similarity:	81/234 - (34%)	Gaps:	42/234 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 PPPHAARTEGGGQDMEDSDEEMEYMPPLHKQFHIFVGDLSSEIETQQLREAFTPFGEISDCRVVR 345
            |||.....|....|.    .|:.:....|:   :.|.:|.:.:..|.|::.|...|.::...|..
Yeast   237 PPPSNNIKERKALDR----GELRHNRKTHE---VIVKNLPASVNWQALKDIFKECGNVAHADVEL 294

  Fly   346 DPQTLKSKGYGFVSFIKKSEAESAITAMNGQWLGSRSIRTNWATRKPPASKENIK---------- 400
            |...: |.|.|.|||....:...||...||.     ||..|....|   |||::.
Yeast   295 DGDGV-STGSGTVSFYDIKDLHRAIEKYNGY-----SIEGNVLDVK---SKESVHNHSDGDDVDI 350

  Fly   401 PLTFDEVYNQSSPSNCTVYVGGVNSAL---------TALSEEVLQKTFAPYGAIQEIRVFKDK-- 454
            |:....|..::......|..||..:.|         ||.|:  |...|...|.:....:..|.
Yeast   351 PMDDSPVNEEARKFTENVVGGGERNRLIYCSNLPFSTAKSD--LYDLFETIGKVNNAELRYDSKG 413

  Fly   455 ---GYAFVRFSTKEAATHAIVGVHNTEINAQPVKCSWGK 490
               |.|.|.:...:.|...|..::|.......:..|:.|
Yeast   414 APTGIAVVEYDNVDDADVCIERLNNYNYGGCDLDISYAK 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trv	NP_001163754.3	RRM2_TIA1_like	313..387	CDD:240799	20/73 (27%)
trv	NP_001163754.3	RRM3_TIA1_like	416..491	CDD:240800	19/89 (21%)
HRB1	NP_014394.2	PRK12678	<29..>85	CDD:237171
		RRM1_HRB1_GBP2	160..236	CDD:410184
		RRM2_HRB1_GBP2	262..334	CDD:410185	21/80 (26%)
		RRM3_HRB1_GBP2	374..452	CDD:410186	15/79 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910