DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trv and tia1l

DIOPT Version :9

Sequence 1:	NP_001163754.3	Gene:	trv / 43362	FlyBaseID:	FBgn0085391	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_956476.1	Gene:	tia1l / 323447	ZFINID:	ZDB-GENE-030131-2167	Length:	342	Species:	Danio rerio

Alignment Length:	362	Identity:	148/362 - (40%)
Similarity:	186/362 - (51%)	Gaps:	90/362 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 AAAAVSAYQRNGKLPRNLPALRAMEMALRTNSFATPPAPHSLPLPPPHAARTEGGGQDMEDSDEE 301
            ||||::|  .||:        :.:...::.|..:||                  ..|..:.|:
Zfish    61 AAAALAA--MNGR--------KILGKDMKVNWASTP------------------SSQKKDTSN-- 95

  Fly   302 MEYMPPLHKQFHIFVGDLSSEIETQQLREAFTPFGEISDCRVVRDPQTLKSKGYGFVSFIKKSEA 366
                     .||:||||||.||.|..:|.||.|||:|||.|||:|..|.|||||||:|||.|.:|
Zfish    96 ---------HFHVFVGDLSPEISTDDVRAAFAPFGKISDARVVKDLATGKSKGYGFISFINKWDA 151

  Fly   367 ESAITAMNGQWLGSRSIRTNWATRKPPASKEN-----IKPLTFDEVYNQSSPSNCTVYVGGVNSA 426
            ||||..|||||||.|.||||||||||.|.|.|     .|.|:::||.|||||||||||.||:.|
Zfish   152 ESAIQQMNGQWLGGRQIRTNWATRKPSAPKSNNEGASSKHLSYEEVLNQSSPSNCTVYCGGIAS- 215

  Fly   427 LTALSEEVLQKTFAPYGAIQEIRVFKDKGYAFVRFSTKEAATHAIVGVHNTEINAQPVKCSWGKE 491
              .||::::::||:|:|.|.|||||.:|||:||||.:.|.|.||||.|:.|.|....|||.||||
Zfish   216 --GLSDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFDSHEGAAHAIVSVNGTCIEGHTVKCYWGKE 278

  Fly   492 SGDPNNAQTIATQALNSAAAAAAGFPYGVGAAAAAAAYGQQLA--ATGCWYSPTPTYPASSATAA 554
            :.|..:.|.:.....|....||.  ||  |....:...|||:.  ....|..||
Zfish   279 TADMRSMQQMPMPQQNKPTYAAQ--PY--GQWGQSYGNGQQMGQYVPNGWQMPT----------- 328

  Fly   555 AVTPAAASAAAVQNQFLQGIQGYHFGQYG--GYQQGY 589
                                    :|.||  ..||||
Zfish   329 ------------------------YGVYGQAWNQQGY 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trv	NP_001163754.3	RRM2_TIA1_like	313..387	CDD:240799	51/73 (70%)
trv	NP_001163754.3	RRM3_TIA1_like	416..491	CDD:240800	40/74 (54%)
tia1l	NP_956476.1	ELAV_HUD_SF	7..272	CDD:273741	120/252 (48%)
		RRM_SF	10..90	CDD:302621	10/56 (18%)
		RRM2_TIA1	96..175	CDD:241062	55/78 (71%)
		RRM3_TIAR	206..278	CDD:241064	40/74 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6775
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1066369at2759
OrthoFinder	1	1.000	-	-		FOG0000924
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10352
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.020