Protein Alignment trv and Tial1

DIOPT Version :10

• Sequence 1: NP_001163754.3
• Gene: trv / 43362
• FlyBaseID: FBgn0085391
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_033409.1
• Gene: Tial1 / 21843
• MGIID: 107913
• Length: 392
• Species: Mus musculus
• Alignment Length: 415
• Identity: 162/415 - (39%)
• Similarity: 205/415 - (49%)
• Gaps: 116/415 - (27%)

  Fly   237 AAAAVSAYQRNGKLPRNLPALRAMEMALRTNSFATPPAPHSLPLPPPHAARTEGGGQDMEDSDEE 301
            ||||::|  .||:        :.:...::.| :||.|:                 .|..:.|:
Mouse    78 AAAALAA--MNGR--------KILGKEVKVN-WATTPS-----------------SQKKDTSN-- 112

  Fly   302 MEYMPPLHKQFHIFVGDLSSEIETQQLREAFTPFGEISDCRVVRDPQTLKSKGYGFVSFIKKSEA 366
                     .||:||||||.||.|:.::.||.|||:|||.|||:|..|.||||||||||..|.:|
Mouse   113 ---------HFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDA 168

  Fly   367 ESAITAMNGQWLGSRSIRTNWATRKPPASKE----NIKPLTFDEVYNQSSPSNCTVYVGGVNSAL 427
            |:||..|.|||||.|.||||||||||||.|.    |.|.|.|::|.|||||.|||||.||:.|.|
Mouse   169 ENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQETNTKQLRFEDVVNQSSPKNCTVYCGGIASGL 233

  Fly   428 TALSEEVLQKTFAPYGAIQEIRVFKDKGYAFVRFSTKEAATHAIVGVHNTEINAQPVKCSWGKES 492
            |   ::::::||:|:|.|.|||||.:|||:||||||.|:|.||||.|:.|.|....|||.|||||
Mouse   234 T---DQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKES 295

  Fly   493 GDPNNAQTIATQALNSAAAAAAGFPYGVGAAAAAAAYGQQLAATGCWYSPTPTYPASSATAAAVT 557
            .|    .|...|.::.:........||     ....|||.:|
Mouse   296 PD----MTKNFQQVDYSQWGQWSQVYG-----NPQQYGQYMA----------------------- 328

  Fly   558 PAAASAAAVQNQFLQGIQGYHFGQYGGYQQGY--MGMGV-QIP-ATWQGVTQAQISPAQQLATGV 618
                             .|:....||.|.|.:  .|.|| |.| |.|.|...||  |.|
Mouse   329 -----------------NGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQ--PPQ------ 368

  Fly   619 AGTAIP-------QAA-GVVAYPIQ 635
             |.|.|       ||. |:.::|.|
Mouse   369 -GQAPPPVIPPPNQAGYGMASFPTQ 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trv	NP_001163754.3	RRM2_TIA1_like	313..387	CDD:409789	48/73 (66%)
		RRM3_TIA1_like	416..489	CDD:409790	40/72 (56%)
Tial1	NP_033409.1	RRM1_TIAR	10..107	CDD:410028	11/56 (20%)
		RRM2_TIAR	113..192	CDD:410029	52/78 (67%)
		RRM3_TIAR	222..294	CDD:241064	42/74 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..392		11/37 (30%)